31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN

G. Brinkmann; U. H. Melchert; G. Lalk; M. Heller

31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN

Translated title of the contribution: 31P-MR spectroscopy of liver abnormalities with reference to varying pulse recovery times

G. Brinkmann^*, U. H. Melchert, G. Lalk, M. Heller

^*Corresponding author for this work

Institute of Neuroradiology

University of Kiel

5 Citations (Scopus)

Abstract

The value of ³¹P-MRS for different types of liver disease and the effect of repetition time (T(R)) on measurements of relative phosphor metabolite concentrations was studied. Spectroscopy was performed on 26 patients with predominantly focal liver disease and on 14 normals, using a 1.5 Tesla clinical MR system. In all cases, (T(R)) of 2,400 ms was chosen and in 11 patients and 10 normals additionally shorter (T(R)) of 600 ms (with T₁ weighted spectra) was chosen. The results show that PME/β-ATP and PDE/β-ATP are sensitive indicators of liver disease and differ widely from the findings in normal livers. In patients with liver metastases, the long (T(R)) of 2,400 ms (16 cases) showed an increase of PME/β-ATP (0.96 ± 0.32) and significant reduction of PDE/β-ATP (1.89 ± 0.47) as compared with normals (PME/β-ATP = 0.75 ± 0.26 and PDE/β-ATP = 2.27 ± 0.41), for a (T(R)) of 600 ms, PME/β-ATP (0.87 ± 0.47) and PDE/β-ATP (1.82 ± 0.67) are significantly increased. T₁ weighted spectra showed more significant differences in phosphometabolites between patients and normals than density weighted spectra. The spectra in patients showed a significantly reduced signal to noise ratio independent of the (T(R)).

Translated title of the contribution	31P-MR spectroscopy of liver abnormalities with reference to varying pulse recovery times
Original language	German
Journal	RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren
Volume	159
Issue number	5
Pages (from-to)	412-418
Number of pages	7
ISSN	0936-6652
Publication status	Published - 01.01.1993

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@article{bdc7b726d86044549713dcda39266ae8,

title = "31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN",

abstract = "The value of 31P-MRS for different types of liver disease and the effect of repetition time (T(R)) on measurements of relative phosphor metabolite concentrations was studied. Spectroscopy was performed on 26 patients with predominantly focal liver disease and on 14 normals, using a 1.5 Tesla clinical MR system. In all cases, (T(R)) of 2,400 ms was chosen and in 11 patients and 10 normals additionally shorter (T(R)) of 600 ms (with T1 weighted spectra) was chosen. The results show that PME/β-ATP and PDE/β-ATP are sensitive indicators of liver disease and differ widely from the findings in normal livers. In patients with liver metastases, the long (T(R)) of 2,400 ms (16 cases) showed an increase of PME/β-ATP (0.96 ± 0.32) and significant reduction of PDE/β-ATP (1.89 ± 0.47) as compared with normals (PME/β-ATP = 0.75 ± 0.26 and PDE/β-ATP = 2.27 ± 0.41), for a (T(R)) of 600 ms, PME/β-ATP (0.87 ± 0.47) and PDE/β-ATP (1.82 ± 0.67) are significantly increased. T1 weighted spectra showed more significant differences in phosphometabolites between patients and normals than density weighted spectra. The spectra in patients showed a significantly reduced signal to noise ratio independent of the (T(R)).",

author = "G. Brinkmann and Melchert, {U. H.} and G. Lalk and M. Heller",

year = "1993",

month = jan,

day = "1",

language = "Deutsch",

volume = "159",

pages = "412--418",

journal = "RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren",

issn = "0936-6652",

number = "5",

}

31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN. / Brinkmann, G.; Melchert, U. H.; Lalk, G. et al.
In: RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, Vol. 159, No. 5, 01.01.1993, p. 412-418.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - 31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN

AU - Brinkmann, G.

AU - Melchert, U. H.

AU - Lalk, G.

AU - Heller, M.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The value of 31P-MRS for different types of liver disease and the effect of repetition time (T(R)) on measurements of relative phosphor metabolite concentrations was studied. Spectroscopy was performed on 26 patients with predominantly focal liver disease and on 14 normals, using a 1.5 Tesla clinical MR system. In all cases, (T(R)) of 2,400 ms was chosen and in 11 patients and 10 normals additionally shorter (T(R)) of 600 ms (with T1 weighted spectra) was chosen. The results show that PME/β-ATP and PDE/β-ATP are sensitive indicators of liver disease and differ widely from the findings in normal livers. In patients with liver metastases, the long (T(R)) of 2,400 ms (16 cases) showed an increase of PME/β-ATP (0.96 ± 0.32) and significant reduction of PDE/β-ATP (1.89 ± 0.47) as compared with normals (PME/β-ATP = 0.75 ± 0.26 and PDE/β-ATP = 2.27 ± 0.41), for a (T(R)) of 600 ms, PME/β-ATP (0.87 ± 0.47) and PDE/β-ATP (1.82 ± 0.67) are significantly increased. T1 weighted spectra showed more significant differences in phosphometabolites between patients and normals than density weighted spectra. The spectra in patients showed a significantly reduced signal to noise ratio independent of the (T(R)).

AB - The value of 31P-MRS for different types of liver disease and the effect of repetition time (T(R)) on measurements of relative phosphor metabolite concentrations was studied. Spectroscopy was performed on 26 patients with predominantly focal liver disease and on 14 normals, using a 1.5 Tesla clinical MR system. In all cases, (T(R)) of 2,400 ms was chosen and in 11 patients and 10 normals additionally shorter (T(R)) of 600 ms (with T1 weighted spectra) was chosen. The results show that PME/β-ATP and PDE/β-ATP are sensitive indicators of liver disease and differ widely from the findings in normal livers. In patients with liver metastases, the long (T(R)) of 2,400 ms (16 cases) showed an increase of PME/β-ATP (0.96 ± 0.32) and significant reduction of PDE/β-ATP (1.89 ± 0.47) as compared with normals (PME/β-ATP = 0.75 ± 0.26 and PDE/β-ATP = 2.27 ± 0.41), for a (T(R)) of 600 ms, PME/β-ATP (0.87 ± 0.47) and PDE/β-ATP (1.82 ± 0.67) are significantly increased. T1 weighted spectra showed more significant differences in phosphometabolites between patients and normals than density weighted spectra. The spectra in patients showed a significantly reduced signal to noise ratio independent of the (T(R)).

UR - http://www.scopus.com/inward/record.url?scp=0027340055&partnerID=8YFLogxK

M3 - Zeitschriftenaufsätze

C2 - 8219133

AN - SCOPUS:0027340055

SN - 0936-6652

VL - 159

SP - 412

EP - 418

JO - RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren

JF - RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren

IS - 5

ER -

31P-MR-SPEKTROSKOPIE VON LEBERERKRANKUNGEN UNTER BERUCKSICHTIGUNG VON UNTERSCHIEDLICHEN PULSWIEDERHOLUNGSZEITEN

Abstract

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