α-fluoromethyl tryptophans via imino ene reaction

S. N. Osipov; N. M. Kobel'Kova; A. F. Kolomiets; K. Pumpor; B. Koksch; K. Burger

doi:10.1055/s-2001-16054

α-fluoromethyl tryptophans via imino ene reaction

S. N. Osipov, N. M. Kobel'Kova, A. F. Kolomiets, K. Pumpor, B. Koksch, K. Burger^*

^*Corresponding author for this work

Institute of Biochemistry

University of Leipzig

12 Citations (Scopus)

Abstract

A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene indolines.

Original language	English
Journal	Synlett
Issue number	8
Pages (from-to)	1287-1289
Number of pages	3
ISSN	0936-5214
DOIs	https://doi.org/10.1055/s-2001-16054
Publication status	Published - 2001

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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title = "α-fluoromethyl tryptophans via imino ene reaction",

abstract = "A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene indolines.",

author = "Osipov, {S. N.} and Kobel'Kova, {N. M.} and Kolomiets, {A. F.} and K. Pumpor and B. Koksch and K. Burger",

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language = "English",

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T1 - α-fluoromethyl tryptophans via imino ene reaction

AU - Osipov, S. N.

AU - Kobel'Kova, N. M.

AU - Kolomiets, A. F.

AU - Pumpor, K.

AU - Koksch, B.

AU - Burger, K.

PY - 2001

Y1 - 2001

N2 - A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene indolines.

AB - A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene indolines.

UR - http://www.scopus.com/inward/record.url?scp=0034902611&partnerID=8YFLogxK

U2 - 10.1055/s-2001-16054

DO - 10.1055/s-2001-16054

M3 - Journal articles

AN - SCOPUS:0034902611

SN - 0936-5214

SP - 1287

EP - 1289

JO - Synlett

JF - Synlett

IS - 8

ER -

α-fluoromethyl tryptophans via imino ene reaction

Abstract

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