Psychophysiological methods in the context of pharmacological and behavioral treatment approaches of Gilles-de-la-Tourette Syndrome

  • Beste, Christian (Principal Investigator (PI))
  • Münchau, Alexander (Principal Investigator (PI))
  • Roessner, Veit (Principal Investigator (PI))

    Project: DFG ProjectsDFG Individual Projects

    Project Details


    Goal of the intended project is to analyze the mode of action of pharmacological and behavioral therapeutic interventions in the treatment of Gilles-de-la-Tourette Syndrome (GTS) using psychophysiological methods. The primary evaluation relates to the analysis of action control processes using EEG techniques on the basis of computational basal ganglia models and the neurobiology of fronto-striatal circuits. As secondary parameters, inventories assessing the severeness of GTS and quality of life will be used and this data integrated with the psychophysiological data. Besides an applied focus of research pursued in this project, the project will also provide insights into cognitive functions in one of the most prevalent neuropsychiatric disorders in childhood and youth, which may be viewed as a disease-model of dopaminergic hyperfunction. Results of the study will therefore contribute to the understanding of the processes underlying treatment of GTS and to role of fronto-striatal circuits for cognitive control processes.

    Key findings

    Im Rahmen des Projektes wurden auf Basis eines theoretischen Konzeptes Wirkmechanismen zweier wesentlicher Interventionen bei Tourette untersucht (Tiaprid und CBIT Intervention). Die Ergebnisse der Untersuchungen erlaubten neue Einblicke in die Wirkweise der Interventionen (insbes. der CBIT-Intervention), die im Kontext neuer Sichtweisen auf das Tourette Syndrom wesentlich zum Verständnis des Tourette Syndroms und möglicher Behandlungsstrategien beitragen. Derzeitig werden im Rahmen der neu etablierten Forschergruppe weitere Experimente zu diesem Thema durchgeführt und die Datenanalysen aus dem dargestellten Berichtszeitraum beendet.
    Effective start/end date01.01.1531.12.18

    UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being
    • SDG 10 - Reduced Inequalities

    Research Areas and Centers

    • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

    DFG Research Classification Scheme

    • 110-01 General, Cognitive and Mathematical Psychology
    • 206-10 Clinical Psychiatry, Psychotherapy amd Paediatric and Juvenile Psychiatrie