Platelet-derived chemokines play a critical (patho)physiological role in inflammation following organ ischaemia. We will analyse the impact of platelet CXCL-chemokines and CXC-receptors on thrombo-inflammation following organ ischaemia (heart and brain). Further, the importance of the platelet-CXCL/CXCR-axis for recovery of the failing ischaemic myocardium using a variety of genetic mouse strains will be elaborated. We will mirror our experimental results with clinical studies of patients with acute organ ischaemia. The project is aimed at developing novel therapeutic strategies for ischaemic organ dysfunction with currently limited treatment options.
|Effective start/end date||01.01.18 → …|
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
DFG Research Classification Scheme
- 205-14 Haematology, Oncology, Transfusion Medicine
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