Outlive-CRC - Liquid Biopsy and Nutrition in CRC Prevention

Project: Projects with Federal FundingProjects with Federal Ministry Funding: BMBF

Project Details

Description

The OUTLIVE-CRC consortium combines scientific expertise from the fields of molecular oncology and cancer prevention from the University of Lübeck (UzL), the University Hospital Schleswig-Holstein Campus Lübeck (UKSH) and the German Cancer Research Center Heidelberg (DKFZ) complemented by microfluidics experts from the Hahn-Schickard Institute and a start-up company (Perfood GmbH) specializing in digital therapeutics for nutritional medicine.

As part of the OUTLIVE-CRC consortium, we are focusing on tertiary prevention to improve the prognosis and quality of life of CRC patients under the age of 50. In a comprehensive approach, we will develop a multi-marker risk panel that includes multi-OMICS liquid biopsy data covering signatures related to residual tumor cells, biological age, and nutritional status.

We are evaluating nutritional and socio-medical interventions for quality of life and signatures related to risk of tumor recurrence. Microfluidic automation will be applied to enable point-of-care application of the multimarker panel to improve early detection of CRC in young patient:s.

The project complements an app development to promote optimal nutrition. The various interventions aim to increase physical activity and social participation. The active involvement of patients in all phases of the project aligns the interventions with their needs to improve tertiary prevention of colorectal cancer in young patients.

Young colorectal cancer patients under the age of 50 are at risk of relapse and their participation in professional and social life is particularly impaired. Therefore, in addition to effective screening and early detection programs, long-term follow-up care and lifestyle adjustment are required. Specialists from various disciplines such as oncology, nutritional medicine, gastroenterology, surgery, epidemiology and systems biology have joined forces in this project to develop offers to prevent relapse or detect it as early as possible.

As part of the OUTLIVE-CRC (Colorectal Cancer, CRC for short) project, information on intestinal metabolism, the intestinal microbiome and other molecular levels, among other things, will be collected from stool and blood samples of patients and analyzed using artificial intelligence. In this way, the researchers hope to find biomarkers that indicate developing cancer at a particularly early stage. The influence of personalized nutrition will also be investigated. A special feature of the alliance is the continuous involvement of patients, so that research is closely aligned with the needs of those affected and their relatives. Participation is implemented in the subprojects in various gradations, for example in the form of consultation, involvement or collaboration.

Various institutions of the UKSH and the University of Lübeck participate in the research network: In addition to the two mentioned, the Institute for Nutritional Medicine and the Clinic for Hematology and Oncology, these include the Section for Nutritional Medicine of the Medical Clinic I, the Institute for Social Medicine and Epidemiology, the Interdisciplinary Center for Biobanking-Lübeck, the Section for Translational Surgical Oncology and Biobanking of the Clinic for Surgery and the Department of Medical Systems Biology. Further partners are the German Cancer Research Center in Heidelberg, the Hahn-Schickard-Gesellschaft für angewandte Forschung e. V. in Freiburg and Perfood GmbH, Lübeck.

In this project, the Institute of Social Medicine and Epidemiology is responsible for the involvement and participation of patients and the documentation and analysis of follow-up data.
StatusActive
Effective start/end date01.03.2231.12.25

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Research Area: Center for Population Medicine and Public Health (ZBV)
  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

  • 205-05 Nutritional Science, Nutritional Medicine
  • 205-01 Epidemiology, Medical Biometrics/Statistics
  • 205-14 Haematology, Oncology

Funding Institution

  • Federal Ministries: BMBF (Education and Research)