Modulation of neuroinflammation by novel endothelial GPCRs

  • Schwaninger, Markus (Principal Investigator (PI))
  • Wettschureck, Nina (Principal Investigator (PI))

Project: DFG ProjectsDFG Individual Projects

Project Details

Description

G-protein-coupled receptors (GPCRs) mediate the intracellular effects of a multitude of systemic and local mediators and thereby modulate endothelial cell (EC) function. Here, we study the role of three GPCRs that have so far not been implicated in EC biology, two orphan GPCRs, GPRC5B and GPR153, and a metabolite GPCR that was not known to be expressed in EC, the short chain fatty acid receptor HCA2. All three GPCRs are upregulated in EC of the blood-brain barrier in response to inflammation, and preliminary data show that their genetic inactivation alters EC barrier function for leukocytes and humoral factors. With the help of tamoxifen-inducible, EC-specific knockout mice, we will analyse the in-vivo function of these novel GPCRs in autoimmune and ischemic neuroinflammation, and dissect the underlying molecular mechanisms.
StatusActive
Effective start/end date01.01.2131.12.25

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 206-05 Experimental Models for Investigating Diseases of the Nervous System