INDICATE-FH: New approaches in the diagnosis and treatment of food intolerances

  • Sina, Christian (Principal Investigator (PI))
  • Jappe, Uta (Principal Investigator (PI))
  • Bischoff, Stephan C. (Principal Investigator (PI))
  • Burziwoda, Dominik (Principal Investigator (PI))

Project: Projects with Federal FundingProjects with Federal Ministry Funding: BMBF

Project Details


More and more people cannot tolerate wheat. This may be due to a wheat allergy or gluten intolerance (coeliac disease), both of which are clearly defined diseases. However, wheat intolerance often has other causes, the diagnosis of which has so far been very complex. The symptoms in the gastrointestinal tract are sometimes misdiagnosed as irritable bowel syndrome, which leads to suboptimal treatment.

The main aim of the "INDICATE-FH" project is to improve the diagnosis and treatment of wheat-dependent food intolerances. To this end, the interdisciplinary project team will develop diagnostic procedures that can differentiate between the various causes of wheat intolerance and distinguish them from irritable bowel syndrome.

Among other things, a special form of endoscopy is being optimized - confocal laser endomicroscopy (CLE). The evaluation of endoscopic images is to be improved using artificial intelligence. Several sub-projects are also working on diagnosing wheat intolerances using blood, saliva or stool samples. Another approach involves the further development of an app that collects data from wearables and data on diet, lifestyle and symptoms.
Effective start/end date01.01.2131.12.24

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 205-05 Nutritional Science, Nutritional Medicine