CRC/Transregio TRR 22, Project A21: The role of the anaphylatoxins C3a and C5a in the pathogenesis of experimental allergic asthma

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

During the last decades, allergies have emerged as a group of major diseases with bronchial asthma as the most severe manifestation at the respiratory tract. Although allergies have a marked socio-economic impact, the pathophysiology is still purely understood. There is no causal therapy available, prevention and prediction are still insufficient. It is the aim of this Transregional Collaborative Research Centre to tackle these problems and, eventually, to develop new therapeutic and preventive strategies for allergic disease based on the development of a better understanding of the pathophysiology due to the concerted action of this consortium.
During the last years, the regulation of the allergen-specific immune response has been the focus of many research activities. This has led to a better understanding of the contribution of T-cell subsets and the regulation of IgE-production as an important effector mechanism. However, the process from initiation to chronification is still purely understood. Respiratory epithelium has not only a barrier function, but seems to contribute to the pathogenesis via immuno-modulatory effector mechanism. In this context, the epithelium is the first cell-type which primarily interacts with inhaled allergens and microbial components of the environment. Particularly this chronic microbial exposure (e.g. via inhalation) has been claimed to have important priming effects on immune responses against allergens. As an example, lipopolysaccacharides (LPS) have been best examined in this regard. However, endotoxins are only a model antigen in this context which can have such a protective effect. In addition to such environmental components, genetics also plays a very important role in the development of the allergic phenotype. Major research interests include protein-protein, gene-protein and gene-gene interactions.
The partners from Marburg, Borstel and Munich represent leading scientists, covering the areas of clinical and experimental pneumology, clinical and experimental allergology, epidemiology, microbiology and immunology, biochemistry and genetics.
Recent research data indicate a strong association between the microbial environment and allergy development. Based on these results a better understanding of the cellular and molecular mechanism will be developed. In the second and third funding period this should lead to translational and clinical research activities aimed for novel preventive and therapeutic concepts.
Statusfinished
Effective start/end date01.01.0931.12.14

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 204-05 Immunology