During the last years, the regulation of the allergen-specific immune response has been the focus of many research activities. This has led to a better understanding of the contribution of T-cell subsets and the regulation of IgE-production as an important effector mechanism. However, the process from initiation to chronification is still purely understood. Respiratory epithelium has not only a barrier function, but seems to contribute to the pathogenesis via immuno-modulatory effector mechanism. In this context, the epithelium is the first cell-type which primarily interacts with inhaled allergens and microbial components of the environment. Particularly this chronic microbial exposure (e.g. via inhalation) has been claimed to have important priming effects on immune responses against allergens. As an example, lipopolysaccacharides (LPS) have been best examined in this regard. However, endotoxins are only a model antigen in this context which can have such a protective effect. In addition to such environmental components, genetics also plays a very important role in the development of the allergic phenotype. Major research interests include protein-protein, gene-protein and gene-gene interactions.
The partners from Marburg, Borstel and Munich represent leading scientists, covering the areas of clinical and experimental pneumology, clinical and experimental allergology, epidemiology, microbiology and immunology, biochemistry and genetics.
Recent research data indicate a strong association between the microbial environment and allergy development. Based on these results a better understanding of the cellular and molecular mechanism will be developed. In the second and third funding period this should lead to translational and clinical research activities aimed for novel preventive and therapeutic concepts.
|Effective start/end date||01.01.09 → 31.12.14|
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
DFG Research Classification Scheme
- 204-05 Immunology