CRU 303, Subproject 02: The Skin Microbiome Modulating Pemphigoid Diseases

  • Baines, John F. (Principal Investigator (PI))
  • Schmidt, Enno (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Research Units/ Clinical Research Units

Project Details

Description

The skin is a critical organ providing barrier function between the host and environment, yet provides a range of niches for diverse microbial communities. The skin microbiota play an increasingly recognized role in immunity and local inflammatory responses and are associated with some chronic inflammatory diseases afflicting the skin. We previously demonstrated an important role of the skin microbiota in a mouse model of the autoimmune skin blistering disease epidermolysis bullosa acquisita. Because of its potentially important role in modulating susceptibility and pathophysiology, this proposal aims to provide a first thorough description of the skin microbiome in pemphigoid diseases (PD) patients. Through the use of highly developed statistical analysis of bacterial communities in PD patients and controls, we further aim to identify individual taxa (i.e. "microbiomarkers") with potential therapeutic value for future functional characterization and clinical application.
Statusfinished
Effective start/end date01.04.1531.12.22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 205-19 Dermatology
  • 204-05 Immunology

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