CRC/Transregio TRR 296, Project P05: Novel pharmacotherapies for the treatment of central TH deprivation associated with Mct8/Oatp1c1 deficiency

  • Pfluger, Paul (Principal Investigator (PI))
  • Müller, Timo (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


In this proposal we will evaluate a series of novel TH/peptide chimeras for their ability to improve brain TH deficiency associated with AHDS. Studies will include LSFM and MS-based assessment of drug BBB permeability, advanced in vitro and in vivo approaches to delineate proof-of-concept and drugability of central Mct8 deficiency and state-of-the-art genetic, microscopic, transcriptomic and proteomic approaches to further advance our knowledge on the neuronal and behavioral underpinnings underlying disturbed Mct8 expression and function.
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism