Projects per year
Project Details
Description
In this proposal we will evaluate a series of novel TH/peptide chimeras for their ability to improve brain TH deficiency associated with AHDS. Studies will include LSFM and MS-based assessment of drug BBB permeability, advanced in vitro and in vivo approaches to delineate proof-of-concept and drugability of central Mct8 deficiency and state-of-the-art genetic, microscopic, transcriptomic and proteomic approaches to further advance our knowledge on the neuronal and behavioral underpinnings underlying disturbed Mct8 expression and function.
| Status | Active |
|---|---|
| Effective start/end date | 01.01.20 → … |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
DFG Research Classification Scheme
- 2.22-17 Endocrinology, Diabetology, Metabolism
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Projects
- 1 Active
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CRC/Transregio TRR 296 LocoTact: Local control of TH action
Führer-Sakel, D. (Speaker, Coordinator), Mittag, J. (Second Speaker/Coordinator), Kühnen, P. (Second Speaker/Coordinator), Heuer, H. (Principal Investigator (PI)), Schwaninger, M. (Principal Investigator (PI)), Müller-Fielitz, H. (Principal Investigator (PI)), Bechmann, I. (Principal Investigator (PI)), Biebermann, H. (Principal Investigator (PI)), Müller, T. (Principal Investigator (PI)), Pfluger, P. (Principal Investigator (PI)), Krude, H. (Principal Investigator (PI)), Schülke-Gerstenfeld, M. (Principal Investigator (PI)), Cirkel, A. (Principal Investigator (PI)), Münte, T. (Principal Investigator (PI)), Kleinschnitz, C. (Principal Investigator (PI)), Langhauser, F. (Principal Investigator (PI)), Engel, D. R. (Principal Investigator (PI)), Möller, L. (Principal Investigator (PI)), Kaiser, F. (Principal Investigator (PI)), Oster, H. (Principal Investigator (PI)), Kirchner, H. (Principal Investigator (PI)), Spranger, J. (Principal Investigator (PI)), Tacke, F. (Principal Investigator (PI)), Wirth, E. K. (Principal Investigator (PI)), Köhrle, J. (Principal Investigator (PI)), Schomburg, L. (Principal Investigator (PI)), Lange, C. M. (Principal Investigator (PI)), Zwanziger, D. (Principal Investigator (PI)), Mayerl, S. (Principal Investigator (PI)) & Stachelscheid, H. (Principal Investigator (PI))
01.01.20 → …
Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios