CRC/Transregio TRR 296 LocoTact, Project P14: Control of cellular TH metabolism in human and mouse NASH

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Hepatic TRβ signalling is impaired in human and murine NASH, and vice versa, elevating hepatic TH action improves non-alcoholic hepatosteatosis (NASH). Using human liver biopsies, NASH mouse models and iPSC-derived hepatocytes, we aim to identify the mechanisms that cause reduced TRβ expression in NASH, testing the hypothesis that this is mediated by epigenetic mechanisms involving miRNA and DNA methylation. Finally, we hypothesise that improving hepatic TRβ signalling in NASH will improve current treatment strategies.
Effective start/end date01.01.20 → …

Collaborative partners

  • University of Duisburg-Essen (Joint applicant, Co-PI) (lead)

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism


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