CRC/Transregio TRR 296 LocoTact, Project P13: TH receptor-clock interaction in NAFLD development

Circadian clocks regulate organ responses to external stimuli such as TH through tissue-specific transcriptional programmes. In the liver, many TH target genes show robust circadian regulation, demonstrating temporal modulation of local TH action – despite largely constant tissue T3 levels. We will analyse clock-TRβ interaction in the regulation of hepatic lipid metabolism in mice with genetic disruption of liver clock or TR signalling and test this interaction as a potential TRβ-targeted (chrono-)therapy for fatty liver disease.