CRC/Transregio TRR 296 LocoTact, Project P13: TH receptor-clock interaction in NAFLD development

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Circadian clocks regulate organ responses to external stimuli such as TH through tissue-specific transcriptional programmes. In the liver, many TH target genes show robust circadian regulation, demonstrating temporal modulation of local TH action – despite largely constant tissue T3 levels. We will analyse clock-TRβ interaction in the regulation of hepatic lipid metabolism in mice with genetic disruption of liver clock or TR signalling and test this interaction as a potential TRβ-targeted (chrono-)therapy for fatty liver disease.
Effective start/end date01.01.20 → …

Collaborative partners

  • University of Duisburg-Essen (Joint applicant, Co-PI) (lead)

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism


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