CRC/Transregio TRR 296 LocoTact, Project P12: TH receptor α1 at the crossroad of autonomic and cardiac functions in mice

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


TH is of great importance for cardiac rhythmicity, as tachycardia is often observed in hyperthyroidism, while bradycardia is a leading symptom in hypothyroid patients. It is commonly assumed that the regulation of heart rate by TH is predominantly an effect of TH within the heart; however, recent studies showed that also central TH actions contribute to this phenotype. In the proposed project we now aim to dissect the local from the central actions of TH in the control of heart rate with a focus on the predominant receptor in heart and brain, TRα1.
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism


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