CRC/Transregio TRR 296 LocoTact, Project P09: TH transporters in myelin formation and regeneration

  • Engel, Daniel Robert (Principal Investigator (PI))
  • Heuer, Heike (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


TH regulates myelination in developing and mature CNS. Here, we aim to unravel the cell-intrinsic functions of the TH transporters Mct8 and Oatp1c1 during oligodendrocyte differentiation by studying developmental myelination and myelin repair in cell-specific Mct8/Oatp1c1-deficient mice. We will also test whether novel TH analogues can drive proper myelination in Mct8/Oatp1c1 DKO mice and may thus be considered as treatment option for AHDS.
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism