CRC/Transregio TRR 296 LocoTact, Project P08: Local TH transport and action in ischaemic brain injury

  • Führer-Sakel, Dagmar (Principal Investigator (PI))
  • Kleinschnitz, Christoph (Principal Investigator (PI))
  • Langhauser, Friederike (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Aim of this project is to clarify the time- and cell-specific requirements of TH transport and action for improved outcome in ischaemic brain injury. Cell-specific TH transporter KO mice will be analysed in the experimental stroke model of transient middle cerebral artery occlusion (MCAO) to elucidate the role of TH transport in different cell-types of the blood brain barrier. Treatment with T3 at different dosages and time points will be used to identify the optimal conditions for intervention. The impact of TH on stroke outcome will be analysed by functional, morphological and imaging techniques, e.g. light sheet microscopy and spatial proteomics.
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism


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