Projects per year
Project Details
Description
Local TH action in the brain can be disturbed by mutations in either local transport (MCT8) or receptor proteins (THRA). This project strives to increase the diagnostic yield for both defects by using the serum fT3/fT4-ratio as a more sophisticated screening parameter. Furthermore, we will explore how both genes are regulated on the genomic level. This will enable us to identify i) patients with non-coding mutations, and ii) patients with milder phenotypes presenting only with a subset of symptoms seen in “classic” MCT8 and THRA deficiencies.
| Status | Active |
|---|---|
| Effective start/end date | 01.01.20 → … |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
DFG Research Classification Scheme
- 2.22-17 Endocrinology, Diabetology, Metabolism
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Projects
- 1 Active
-
CRC/Transregio TRR 296 LocoTact: Local control of TH action
Führer-Sakel, D. (Speaker, Coordinator), Mittag, J. (Second Speaker/Coordinator), Kühnen, P. (Second Speaker/Coordinator), Heuer, H. (Principal Investigator (PI)), Schwaninger, M. (Principal Investigator (PI)), Müller-Fielitz, H. (Principal Investigator (PI)), Bechmann, I. (Principal Investigator (PI)), Biebermann, H. (Principal Investigator (PI)), Müller, T. (Principal Investigator (PI)), Pfluger, P. (Principal Investigator (PI)), Krude, H. (Principal Investigator (PI)), Schülke-Gerstenfeld, M. (Principal Investigator (PI)), Cirkel, A. (Principal Investigator (PI)), Münte, T. (Principal Investigator (PI)), Kleinschnitz, C. (Principal Investigator (PI)), Langhauser, F. (Principal Investigator (PI)), Engel, D. R. (Principal Investigator (PI)), Möller, L. (Principal Investigator (PI)), Kaiser, F. (Principal Investigator (PI)), Oster, H. (Principal Investigator (PI)), Kirchner, H. (Principal Investigator (PI)), Spranger, J. (Principal Investigator (PI)), Tacke, F. (Principal Investigator (PI)), Wirth, E. K. (Principal Investigator (PI)), Köhrle, J. (Principal Investigator (PI)), Schomburg, L. (Principal Investigator (PI)), Lange, C. M. (Principal Investigator (PI)), Zwanziger, D. (Principal Investigator (PI)), Mayerl, S. (Principal Investigator (PI)) & Stachelscheid, H. (Principal Investigator (PI))
01.01.20 → …
Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios