CRC/Transregio TRR 296 LocoTact, Project P04: TH action in hiPSC-derived brain organoids

  • Kühnen, Peter (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


TH is critical for brain development and function but knowledge of molecular mechanisms of TH action on human brain development is still very fragmentary. We will study neuronal differentiation and cell type-specific regulation of genes implicated in TH action in hiPCS-derived cerebral organoids in response to conditions mimicking developmental hypo- and hyperthyroidism. In a translational approach, this project further aims at characterising the impact on neuronal development in a human cerebral organoid model system for mutations in key genes involved in local control of TH action.
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism