CRC/Transregio TRR 296 LocoTact: Local control of TH action

  • Führer-Sakel, Dagmar (Speaker, Coordinator)
  • Mittag, Jens (Second Speaker/Coordinator)
  • Kühnen, Peter (Second Speaker/Coordinator)
  • Heuer, Heike (Principal Investigator (PI))
  • Schwaninger, Markus (Principal Investigator (PI))
  • Müller-Fielitz, Helge (Principal Investigator (PI))
  • Bechmann, Ingo (Principal Investigator (PI))
  • Biebermann, Heike (Principal Investigator (PI))
  • Müller, Timo (Principal Investigator (PI))
  • Pfluger, Paul (Principal Investigator (PI))
  • Krude, Heiko (Principal Investigator (PI))
  • Schülke-Gerstenfeld, Markus (Principal Investigator (PI))
  • Cirkel, Anna (Principal Investigator (PI))
  • Münte, Thomas (Principal Investigator (PI))
  • Kleinschnitz, Christoph (Principal Investigator (PI))
  • Langhauser, Friederike (Principal Investigator (PI))
  • Engel, Daniel Robert (Principal Investigator (PI))
  • Möller, Lars (Principal Investigator (PI))
  • Kaiser, Frank (Principal Investigator (PI))
  • Oster, Henrik (Principal Investigator (PI))
  • Kirchner, Henriette (Principal Investigator (PI))
  • Spranger, Joachim (Principal Investigator (PI))
  • Tacke, Frank (Principal Investigator (PI))
  • Wirth, Eva K. (Principal Investigator (PI))
  • Köhrle, Josef (Principal Investigator (PI))
  • Schomburg, Lutz (Principal Investigator (PI))
  • Lange, Christian M. (Principal Investigator (PI))
  • Zwanziger, Denise (Principal Investigator (PI))
  • Mayerl, Steffen (Principal Investigator (PI))
  • Stachelscheid, Harald (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

Circulating concentrations of thyroid hormones (TH) and thyroid stimulating hormone (TSH) are routinely used for diagnosis of thyroid disorders. Recent discoveries of patients with TH transporter or receptor mutations have demonstrated that using circulating hormone levels for assessing thyroid state is fallible, due to several cellular layers controlling TH action. There is accumulating evidence that modulation of TH action in specific tissues can be highly beneficial in pathologies such as non-alcoholic steatohepatitis, myocardial infarction and stroke.
Taken together, these findings have challenged the importance of systemic TH and have shifted the focus onto regulation of TH action at the organ or cell level. With our proposed CRC/TR “Local control of TH action” we will address these challenges in an interdisciplinary manner. Using a globally unique collection of mouse models for all key components of local TH action, defined disease models for rare and prevalent disorders, a human organoid platform, as well as well-characterised patient cohorts, we aim to carefully dissect mechanisms of local control of TH action in physiology and pathophysiology in the most prominent targets, brain, heart and liver. Furthermore, we will evaluate possible therapeutic TH benefits, employing pharmacological tools such as hormone conjugates, genetic model systems and targeted viral gene delivery, aiming to develop cell- and tissue-specific translational strategies.
StatusActive
Effective start/end date01.01.20 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism