CRC/Transregio TRR 240, Project B01: Platelet-dependent inflammation and functional recovery of ischaemic myocardium and brain

Gawaz , Meinrad Paul (Principal Investigator (PI))
Langer, Harald (Principal Investigator (PI))

Clinic of Internal Medicine II - Cardiology

University of Tubingen

Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

Description

Platelet-derived chemokines play a critical (patho)physiological role in inflammation following organ ischaemia. We will analyse the impact of platelet CXCL-chemokines and CXC-receptors on thrombo-inflammation following organ ischaemia (heart and brain). Further, the importance of the platelet-CXCL/CXCR-axis for recovery of the failing ischaemic myocardium using a variety of genetic mouse strains will be elaborated. We will mirror our experimental results with clinical studies of patients with acute organ ischaemia. The project is aimed at developing novel therapeutic strategies for ischaemic organ dysfunction with currently limited treatment options.

Status	finished
Effective start/end date	01.01.18 → 31.12.23

Collaborative partners

University of Würzburg (lead)

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

DFG Research Classification Scheme

2.22-14 Hematology, Oncology