CRC/Transregio TRR 134, Project B05: Exploring the effects of nesfatin-1 in reward-associated and compulsive-like eating

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


The peptide nesfatin-1 possesses pleiotropic functions in the central nervous system as well as in the periphery. Nesfatin-1 is highly expressed in brain regions relevant for the homeostatic regulation of energy intake and expenditure, but also in reward-related circuits. Importantly, we could show that central administration of nesfatin-1 reduces “liking” and “wanting”, suggesting an inhibitory influence on the mesolimbic dopaminergic system. In this project, we aim at investigating the role of endogenous nesfatin-1 and the recruitment of the oxytocin system using an integrative behavioural, pharmacological and molecular/genetic approach. We hypothesize that nesfatin-1 knockdown in reward-related areas would increase the reward value of palatable food and therefore potentiate the activation of the hedonic system, thus contributing to the onset of eating disorders.
Effective start/end date01.01.1431.12.18

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism