CRC/Transregio TRR 134, Project A04: Role of orexin signalling in energy homeostasis and reward processing

  • Jöhren, Olaf (Principal Investigator (PI))
  • Hausen, Anne Christine (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


The neuropeptide orexin is expressed exclusively in the lateral hypothalamus and regulates feeding behaviour and energy homeostasis. In addition, orexinergic neurons interact with dopaminergic and serotonergic systems of the brain and mediate reward-seeking behaviour. Orexins act via orexin type-1 and type-2 receptors which are differentially expressed within the reward circuitry. The goal of this project is to describe downstream neuronal target sites of orexin neurons and to identify the corresponding receptor signalling pathways involved in the homeostatic and hedonic control of energy homeostasis.
Effective start/end date01.01.1401.01.18

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism