CRC 936, Project C05: Characterization of action control networks in genetically determined parkinsonism

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


In the first two funding periods, we found evidence for increased activity of action selection networks in patients with genetically undefined parkinsonism, Parkin- and PINK1-associated parkinsonism, L-dopa-responsive dystonia, and X-linked dystonia parkinsonism. We now focus on network-related processes leading to disease manifestation by comparing asymptomatic mutation carriers with symptomatic patients with Parkin- and PINK1-associated parkinsonism, X-linked dystonia parkinsonism, and GBA-associated parkinsonism. To this end, we will use behavioral tasks, EEG, TMS, pupillometry, and neuromelanin-sensitive high-resolution MRI.
Effective start/end date01.01.1131.12.23

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Research Area: Medical Genetics

DFG Research Classification Scheme

  • 206-07 Clinical Neurology Neurosurgery and Neuroradiology