CRC 914, Project B04: Leukocyte migration and interaction in the context of the developing antibacterial T lymphocyte response

  • Busch, Dirk (Principal Investigator (PI))
  • Verschoor, Admar (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


"Time" and "location" are the defining parameters of leukocyte motility and migration. Systemic Listeria monocytogenes infection in mice provides a unique model to study leukocyte migration and interaction processes during the development of antibacterial immunity. We will use a combination of intravital imaging and ex vivo methods to study how leukocytes capture, handle and traffic bacteria within the splenic marginal zone. In addition, we will study how these events influence the induction of pathogen-specific T lymphocytes in the context of the overall developing antibacterial response.
Effective start/end date01.01.1131.12.23

Collaborative partners

  • Technical University of Munich (Joint applicant, Co-PI)
  • Ludwig-Maximilians-Universität (Joint applicant, Co-PI) (lead)

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 204-05 Immunology

Funding Institution

  • DFG: German Research Association


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