CRC 900, Project B10: Structural flexibility in the Hepatitis C virus glycoprotein complex as viral strategy to evade the humoral immune system

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


The majority of hepatitis C virus (HCV) infected patients fails to clear the virus during the acute phase and conformational flexibility in the glycoprotein E2 was proposed to serve as mechanism to evade from neutralizing antibodies. In this project, we aim to determine the 3D structure of the conformationally flexible epitopes targeted by neutralizing antibodies in the context of the native glycoprotein complex. Furthermore, we will characterize the antibody response of HCV infected patients to these conformationally flexible epitopes.
Effective start/end date01.01.1631.12.22

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 204-04 Virology


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