CRC 654, Project C04: Effects of sleep on quantitative and qualitative aspects of CD4 T-cell memory

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

The subproject includes questions on the release of hormones specifically during sleep (e.g. growth hormone, prolactin) and on the migration behavior of T-lymphocytes into lymphoid tissues and the subsequent passages through the different organ compartments.The expression of cytokines and chemokines is regulated by different hormones.The mechanism will be analyzed quantitatively at the mRNA level. The hypothesis that during sleep the cytokine milieu is modified in a way that promotes a protective immune response will finally be tested in the mouse model using the model infection with Leishmania major.
Statusfinished
Effective start/end date01.07.0530.06.17

Collaborative partners

  • University of Tubingen (Joint applicant, Co-PI) (lead)

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 204-05 Immunology

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  • CRC 654: Plasticity and Sleep

    Born, J.

    01.01.0531.12.17

    Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios