CRC 654, Project C03: Sleep and control of the antimicrobial immune response through CD4+CD25+ regulatory T cells

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Project C 03 of DFG CRC 654 "Plasticity and Sleep"

The aim of this subproject is to understand the influence of sleep, wakefulness and circadian rhythm on the number and function of Treg cells in the context of the antimicrobial immune response. First, Treg cells from peripheral blood of healthy subjects will be quantitatively and functionally characterized under controlled sleep-wake conditions. Subsequently, non-immune subjects will be vaccinated with HBs antigen under different sleep-wake conditions and at different times of the day and their humoral immune responses will be recorded. From a clinical point of view, the results could be used for the development of strategies to improve vaccination success.
Effective start/end date01.01.0531.12.09

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism
  • 204-05 Immunology

Funding Institution

  • DFG: German Research Association
  • CRC 654: Plasticity and Sleep

    Born, J.


    Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios