CRC 654, Project B03: Setpoint regulation during sleep: Influence of intranasal neuropeptides on human neuroendocrine sleep architecture and body weight

  • Kern, Werner (Principal Investigator (PI))
  • Perras, Boris (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Project B 03 of CRC 654 "Plasticity and Sleep":

This subproject will investigate the hypothesis that setpoints for the regulation ofHHN activity and body weight can be readjusted and consolidated during sleep. We will try to influence the setpoints directly by intranasal administration of neuropeptides. Two goals will be pursued: First, to identify neuropeptides capable of inhibiting nocturnal cortisol secretion (ANP, preproTRH(158-183), substance P, insulin, and leptin). Second, to elucidate the importance of sleep in the longer-term modulation of Setpoints. For this purpose, the corresponding neuropeptides must be administered subchronically (i.e., over10-12 weeks) to shift the setpoint of the HHN axis toward lower valuesduring the first half of the night.
Effective start/end date01.01.0531.12.09

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism
  • CRC 654: Plasticity and Sleep

    Born, J.


    Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios