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Project Details
Description
Project B 03 of CRC 654 "Plasticity and Sleep":
This subproject will investigate the hypothesis that setpoints for the regulation ofHHN activity and body weight can be readjusted and consolidated during sleep. We will try to influence the setpoints directly by intranasal administration of neuropeptides. Two goals will be pursued: First, to identify neuropeptides capable of inhibiting nocturnal cortisol secretion (ANP, preproTRH(158-183), substance P, insulin, and leptin). Second, to elucidate the importance of sleep in the longer-term modulation of Setpoints. For this purpose, the corresponding neuropeptides must be administered subchronically (i.e., over10-12 weeks) to shift the setpoint of the HHN axis toward lower valuesduring the first half of the night.
This subproject will investigate the hypothesis that setpoints for the regulation ofHHN activity and body weight can be readjusted and consolidated during sleep. We will try to influence the setpoints directly by intranasal administration of neuropeptides. Two goals will be pursued: First, to identify neuropeptides capable of inhibiting nocturnal cortisol secretion (ANP, preproTRH(158-183), substance P, insulin, and leptin). Second, to elucidate the importance of sleep in the longer-term modulation of Setpoints. For this purpose, the corresponding neuropeptides must be administered subchronically (i.e., over10-12 weeks) to shift the setpoint of the HHN axis toward lower valuesduring the first half of the night.
Status | finished |
---|---|
Effective start/end date | 01.01.05 → 31.12.09 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
DFG Research Classification Scheme
- 2.22-17 Endocrinology, Diabetology, Metabolism
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Projects
- 1 Finished
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CRC 654: Plasticity and Sleep
Born, J. (Speaker, Coordinator)
01.01.05 → 31.12.17
Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios