CRC 654, Project A16: The role of reward- and novelty-related dopaminergic signals in sleep-mediated memory consolidation

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

Sleep promotes consolidation of declarative memories. Here we investigate whether thisconsolidation effect can be found in particular for items that are tagged during encoding,either by being presented in the context of a reward or by being singled out as novel. Inparticular, we assess the flexibility of such tagging processes by manipulating the relativereward (or relative novelty) of a stimulus while keeping absolute reward (or absolute novelty)constant. We hypothesize that both, reward and novelty are coded flexibly by thedopaminergic system and that the activity of a network comprising the ventral tegmental area,the ventral striatum and the hippocampus during encoding is crucial for consolidation ofmemories during sleep.
Statusfinished
Effective start/end date01.03.1228.02.17

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 206-09 Biological Psychiatry

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  • CRC 654: Plasticity and Sleep

    Born, J.

    01.01.0531.12.17

    Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios