We recently demonstrated that stably differentiated Th2 cells can efficiently suppress endogenous CD4+ and CD8+ T cell responses in mouse models of viral infection and autoimmune type 1 diabetes. Therefore, we plan to (1.) investigate the cellular and molecular mechanisms of this T cell suppression and its effects especially on autoimmune diabetes; (2.) generate human Th2 cells with stably immunosuppressive properties; and (3.) analyze the potential Th2 cell stabilizing effects of ustekinumab therapy (anti-IL-12/IL-23 p40) in psoriasis patients.
|Effective start/end date||01.01.13 → 31.12.16|
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
DFG Research Classification Scheme
- 204-05 Immunology