The research program deals with the analysis of the regulation and dysregulation of humoral and cell-mediated reactions during the innate and acquired immune response against infectious agents, in inflammation and certain autoimmune diseases. Particular interest is given to the enzyme type 2 nitric oxide synthase, the IL-4-receptor-mediated signal transduction pathway, immunophilins, chemokine-regulated cell migration and the role of CD1-restricted T-lymphocytes in bacterial-induced immunreaction.In addition the effects of several mediators, i.e. cytokines, integrins etc., are tested in the model of glomerulonephritis, as well as the activation of T cells in inflammatory reactions, integrin-mediated cell migratory processes, and the role of proteasoms in NO-mediated apoptoses are studied.Furthermore principal mechanisms are analysed that result in humoral and cellular immunreactions against autologous structures, such as cartilage-specific collagen II, self-DNA or hemidesmonal proteins on keratinocytes. The three project areas consist of a total of 16 subprojects.
|Effective start/end date||01.01.91 → 31.12.02|
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):