CRC 1526, Project B10: Stromal regulation of inflammation in pemphigoid diseases

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

Pemphigoid diseases (PD) exhibit a relapsing-remitting disease pattern and a preferential affection of certain skin parts, suggesting that local cell populations facilitate regional inflammation. Our preliminary data suggest that dermal fibroblasts (DFs) get metabolically and functionally "primed" by repeated inflammation in the passive transfer model of epidermolysis bullosa acquisita and mediate progressive worsening. In the project, we will delineate the priming response of the skin and focus on mouse and human DFs and their interaction with PD-relevant inflammatory cells. We will also try to "un-prime" DFs by interfering with candidate pathways differentially regulated in primed DFs.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association

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