CRC 1526, Project B08: Microbiota-specific T cell responses in pemphigoid diseases

  • Bacher, Petra (Principal Investigator (PI))
  • Baines, John F. (Principal Investigator (PI))
  • Sadik, Christian (Speaker, Coordinator)

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

The composition of the skin microbiota is altered in pemphigoid diseases (PDs). How this affects specific immune reactions and potentially contributes to skin inflammation is still unknown. We hypothesize that dysregulated microbe-reactive CD4+ T cells driven by an altered skin microbiome may contribute to the pathogenesis of PDs. We will characterize skin microbe-specific T cell responses and correlate these responses with microbial dysbiosis patterns. This will provide knowledge about the contribution of the microbiome and microbe-reactive T cells to PD pathogenesis, instrumental to develop specific therapeutic interventions.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association