CRC 1526, Project B05: Pathophysiology of granulocyte metabolism and its potential as therapeutic target in pemphigoid diseases

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


The flux rate in cellular metabolic pathways generating energy often changes when immune cells transit from the quiescent to the activated stated. In recent years, evidence has accumulated that this change in cell metabolism is a prerequisite for the cell to mount an immune response. Project B05 will profile the metabolism of granulocytes as a major effector cell population in autoantibody-driven autoimmune diseases. It will develop therapeutic strategies for autoimmune diseases disrupting cell metabolism specifically in activated granulocyte populations.
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association