CRC 1526, Project B04: Kinase cascades in neutrophils as therapeutic target in pemphigoid diseases

  • Bieber, Katja (Principal Investigator (PI))
  • Lux, Anja (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

In pemphigoid diseases (PDs), neutrophils are activated by IgG autoantibodies deposited at the dermal-epidermal junction. Intracellular signaling cascades induced by IgG binding to FcγRs ultimately lead to the release of effector molecules, such as proteases and ROS, resulting in skin blistering and erosions. Hence, these signaling cascades, mostly consisting of kinases, are promising therapeutic targets. B04 therefore aims to comprehensively characterize these kinase cascades and to examine the therapeutic potential of inhibitors of select kinases for PDs.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association