CRC 1526, Project A08: Skin-infiltrating T and B cells in the pathogenesis of pemphigoid diseases

  • Ibrahim, Saleh (Principal Investigator (PI))
  • Hutloff, Andreas (Principal Investigator (PI))

Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

Project A08 aims to understand how the T cell-driven local autoantibody production contributes to skin inflammation. We have preliminary data from both pemphigoid disease patients and a mouse model of pemphigoid diseases that so-called peripheral T helper cells interact directly in the skin with inflammatory T-bet+ B cells. Using multi-parametric flow cytometry, laser-scanning microscopy, and single cell sequencing, we plan to dissect these interactions on a molecular level. We furthermore aim to analyze how T and B cells interact with neutrophils and other inflammatory cells in skin infiltrates.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 2.21-05 Immunology
  • 2.22-19 Dermatology

Funding Institution

  • DFG: German Research Association

Project Details

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  • CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Scheffold, A. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Heine, G. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Peipp, M. (Principal Investigator (PI)), Hammers, M. C. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Nimmerjahn, F. (Principal Investigator (PI)), Hutloff, A. (Principal Investigator (PI)), Ibrahim, S. (Principal Investigator (PI)), Wettschureck, N. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)), Schilf, P. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Bacher, P. (Principal Investigator (PI)), Hoffmann, M. (Principal Investigator (PI)), Busch, H. S. (Principal Investigator (PI)), Höppner, M. (Principal Investigator (PI)), Becker, M. (Principal Investigator (PI)), Holtsche, M. M. (Principal Investigator (PI)), Fähnrich, A. (Principal Investigator (PI)), Szymczak, S. (Principal Investigator (PI)), Murthy, S. (Principal Investigator (PI)) & Lux, A. (Principal Investigator (PI))

    01.01.22 → …

    Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios