CRC 1526, Project A06: The role of neutrophils in the regulation of the adaptive immunity in pemphigoid diseases

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

A06 will investigate the role of neutrophils as drivers and modulators of the adaptive immune response in pemphigoid disease. It will characterize neutrophils in different organs and use the photo-convertible transgenic mouse line Kaede to understand their migration pattern in the early phase of the disease. Depletion of neutrophils and use of neutrophil-specific MHC-II knock-out mice will provide insights into their role as drivers and/or initiator of the adaptive immune response in PD. Finally, A06 will investigate the role of anaphylatoxin receptors C5aR1/2, which are essential for neutrophils in the effector phase, also in the afferent phase.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association