CRC 1526, Project A05: Role of the complement receptors 1 and 2 as drivers of autoantibody development and their potential as drug targets in pemphigoid diseases

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

The opsonization of protein antigens with complement C3 adducts and their subsequent interaction with complement receptors 1 and 2 on B cells and Follicular Dendritic Cells, drastically increases immunogenicity. Although these processes may equally promote emergence of PD autoantibodies, this potential of CR1/2 has not yet been addressed. Using PD as paradigm autoimmune diseases, A05 will explore the importance of CR1/2 for the emergence of autoimmunity in the EBA mouse model, their role for conversion from inapparent to clinically overt autoimmunity, and their blockade to prevent or halt autoimmune disease.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 205-19 Dermatology

Funding Institution

  • DFG: German Research Association