CRC 1526, Project A04: Selective B cell depletion in pemphigoid diseases by bispecific antibodies

  • Ludwig, Ralf (Principal Investigator (PI))
  • Peipp, Matthias (Principal Investigator (PI))

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Current treatment options for pemphigoid diseases (PDs) are unsatisfactory. In PD, autoantibodies induce tissue pathology and B cells are therefore central to PD pathogenesis. A04 will develop novel B cell-targeting bispecific T cell engagers that (i) deplete defined B cell populations or (ii) autoantigen-specific B cells by engagement of cytotoxic T cells. A04 will thus decipher the contribution of B cell populations (defined by the expression of single differentiation antigens / CD antigens) to PD pathogenesis and will implement novel and potentially curative treatment strategies in pre-clinical PD models.
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 205-19 Dermatology
  • 204-05 Immunology

Funding Institution

  • DFG: German Research Association