CRC 1526, Project A02: Crosstalk between T cells and B cells in the differentiation of pathogenic plasma cells in pemphigoid diseases

  • Heine, Guido (Principal Investigator (PI))
  • Manz, Rudolf (Principal Investigator (PI))

Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

The bidirectional crosstalk between B and T cells is crucial to for the evolution of pathogenic autoantibodies. Evidence suggests that IFN-γ and retinoic acid (RA) play a significant role as regulators of this interaction. A02 will investigate the molecular mechanisms of the interaction between B and T cells in the evolution of pathogenic autoantibodies using pemphigoid diseases as prototypical example. Herein, A02 will first focus on the role of IFN-γ and RA in this interaction. The final aim of A02 is to develop new strategies treating autoimmune diseases by targeting the evolution of pathogenic autoantibodies.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 2.22-19 Dermatology
  • 2.21-05 Immunology

Funding Institution

  • DFG: German Research Association

Project Details

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  • CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Scheffold, A. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Heine, G. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Peipp, M. (Principal Investigator (PI)), Hammers, M. C. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Nimmerjahn, F. (Principal Investigator (PI)), Hutloff, A. (Principal Investigator (PI)), Ibrahim, S. (Principal Investigator (PI)), Wettschureck, N. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)), Schilf, P. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Bacher, P. (Principal Investigator (PI)), Hoffmann, M. (Principal Investigator (PI)), Busch, H. S. (Principal Investigator (PI)), Höppner, M. (Principal Investigator (PI)), Becker, M. (Principal Investigator (PI)), Holtsche, M. M. (Principal Investigator (PI)), Fähnrich, A. (Principal Investigator (PI)), Szymczak, S. (Principal Investigator (PI)), Murthy, S. (Principal Investigator (PI)) & Lux, A. (Principal Investigator (PI))

    01.01.22 → …

    Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios