CRC 1526, Project A01: Autoantigen-specific T cells in pemphigoid diseases

  • Scheffold, Alexander (Principal Investigator (PI))
  • Schmidt, Enno (Principal Investigator (PI))

Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios

Project Details

Description

Pemphigoid diseases (PDs) are chronic antibody-induced autoimmune diseases (AADs). Autoantigen-specific T helper cells are thought to be centrally involved in the pathogenesis of PDs but remain poorly understood. We have developed antigen-reactive T cell enrichment (ARTE) as a powerful technology for unbiased identification and characterization of autoantigen-specific CD4 regulatory (Tregs) and conventional T cells (Tcon.). A01 will employ ARTE for in-depth characterization of autoreactive T cells from healthy donors and PD patients. Pathogenic and therapeutic T cell functions will be tested in a relevant mouse model.
StatusActive
Effective start/end date01.01.22 → …

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 2.21-05 Immunology
  • 2.22-19 Dermatology

Funding Institution

  • DFG: German Research Association

Project Details

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  • CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Scheffold, A. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Heine, G. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Peipp, M. (Principal Investigator (PI)), Hammers, M. C. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Nimmerjahn, F. (Principal Investigator (PI)), Hutloff, A. (Principal Investigator (PI)), Ibrahim, S. (Principal Investigator (PI)), Wettschureck, N. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)), Schilf, P. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Bacher, P. (Principal Investigator (PI)), Hoffmann, M. (Principal Investigator (PI)), Busch, H. S. (Principal Investigator (PI)), Höppner, M. (Principal Investigator (PI)), Becker, M. (Principal Investigator (PI)), Holtsche, M. M. (Principal Investigator (PI)), Fähnrich, A. (Principal Investigator (PI)), Szymczak, S. (Principal Investigator (PI)), Murthy, S. (Principal Investigator (PI)) & Lux, A. (Principal Investigator (PI))

    01.01.22 → …

    Project: DFG Projects › DFG Joint Research: Collaborative Research Center/ Transregios