CRC 1292, Project 07: Defining the role of hepatocellular carcinoma-related epigenetic alterations driving immune evasion

Project: DFG ProjectsDFG Joint Research: Collaborative Research Center/ Transregios

Project Details


Epigenetic alterations frequently occur in liver cancer and significantly impair tumor-directed immune responses by both, facilitating resistance to the attack of cytotoxic immune cells while concomitantly modulating function and composition of immune cells in the tumor microenvironment. Based on the potential reversibility of epigenetic modifications and, thus, epigenetic driven immune escape mechanisms the characterization of these mechanisms might be of particular importance for the development of novel therapeutic approaches. Here, we will analyze the role of two HCC-associated key epigenetic regulators, DNMT1 and SIRT6, and their related modifications in tumor-directed immune responses
Effective start/end date01.01.1831.12.21

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-15 Gastroenterology


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