CMS4Vent - Alternative methods: In silico methods in ventilation technology - Model development

Intelligent assistance and automation functions in ventilation technology and other areas of medical technology are currently leading to high demand for animal testing, particularly in the large animal sector, as part of preclinical testing of the safety and reliability of medical devices. Preclinical evaluation of such functions using verified and validated digital patient models (in silico trials) offers the potential to significantly reduce the number of animal experiments required.

The aim of the CMS4Vent project is to promote the development of a normative and regulatory framework for the application of computer-based modeling and simulation methods (CM&S) in the preclinical evaluation of medical devices at the European level. The project focuses on the development of a digital patient simulator for conducting in silico trials in ventilation technology, with the aim of replacing animal testing in this area of application as completely as possible. The digital patient simulator for artificial ventilation is intended to serve as a leading example for other areas of medical technology in reducing animal testing.