Otto Roth Award 2017

  • Schuchard, Johanna (Award Recipient)

Prize: Awards of the University of Luebeck

General Description

Dr. Johanna Schuchard is awarded for her outstanding doctoral thesis "An angiotensin(1-7)-dependent mechanism contributes to the prevention of weight gain under AT1 receptor blockade in rats".

Johanna Schuchard, born in Göttingen in 1990, studied human medicine at the University of Lübeck from 2009 to 2015 with a semester abroad at the Università degli Studi di Firenze in Italy. She completed her dissertation from 2013 to 2015 at the Institute of Experimental and Clinical Pharmacology and Toxicology under Prof. Dr. Walter Raasch and was supported for this purpose by the "Excellence Medicine" scholarship of the University of Lübeck in 2013. The dissertation work is based on experimental findings that AT1 receptor antagonists (drugs that are clinically established in the treatment of hypertension and heart failure) also have an anti-adipose effect. Dr. Schuchard was able to show through various functional studies as well as biochemical and molecular investigations that, on the one hand, transgenic rats with angiotensin (1-7) overexpression are protected against the development of obesity and insulin resistance and, on the other hand, that the antiadipose effect of an AT1 receptor antagonist is abolished when non-transgenic rats are simultaneously treated with an antagonist of the Mas receptor. Both findings support the importance of the angiotensin(1-7)/ACE2/Mas cascade in weight regulation and, moreover, that the antiadipose effect of AT1 receptor blockade is at least partly attributable to such a mechanism. Thus, these experimental findings could help improve rational cardiovascular drug therapy for patients with metabolic co-morbidities.

The Otto Roth Award is the Medical Faculty`s annual award for an outstanding doctoral thesis donated by the Society of the University`s Alumni with an amount of 2.500 Euros.
It is named after Professor Otto Roth (1863-1944), the University`s first specialized surgeon. He became head of the Clinic of Surgery in Luebeck`s General Hospital (1897-1933) and collaborated with Heinrich Dräger (1847-1917) for the development of the world world-famous Dräger-Roth anaesthetic apparatus, allowing the thrive of modern anaesthesiology.
Degree of recognitionLocal
Granting OrganisationsVerein der Alumni, Freunde und Förderer der Universität zu Lübeck e. V.

Awarded at event

Event titleUniversity Awards 2017
LocationRathaus der Hansestadt Lübeck, Lübeck, GermanyShow on map

Research Area or Academic Center

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)