Stefanie Derer-Petersen

Research output

Research Output per year 2008 2011 2012 2013 2014 2015 2016 2017 2018 2020 2021 2023

• 44 Journal articles
• 3 Chapter
• 3 Letters
• 1 Scientific review articles

Research Output per year

Research Output per year

Search results

• 2023

  Serum Metabolomic Profiling of Patients with Lipedema

  Kempa, S., Buechler, C., Föh, B., Felthaus, O., Prantl, L., Günther, U. L., Müller, M., Derer-Petersen, S., Sina, C., Schmelter, F. & Tews, H. C., 12.2023, In: International Journal of Molecular Sciences. 24, 24, 17437.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Histidine 100%
  • Phenylalanine 100%
  • Women 100%
  • Pyruvic Acid 100%
  • Low-Density Lipoprotein 66%
• 2022

  The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice

  Nickel, L., Sünderhauf, A., Rawish, E., Stölting, I., Derer, S., Thorns, C., Matschl, U., Othman, A., Sina, C. & Raasch, W., 31.03.2022, In: Frontiers in Pharmacology. 13, 815353.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Telmisartan 100%
  • Mouse 100%
  • Cell Viability 15%
  • Losartan 15%
  • Toxicity 7%
• 2021

  Colorectal cancer progression is potently reduced by a glucose-free, high-protein diet: Comparison to anti-egfr therapy

  Skibbe, K., Brethack, A. K., Sünderhauf, A., Ragab, M., Raschdorf, A., Hicken, M., Schlichting, H., Preira, J., Brandt, J., Castven, D., Föh, B., Pagel, R., Marquardt, J. U., Sina, C. & Derer, S., 01.11.2021, In: Cancers. 13, 22, 5817.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor 100%
  • Cell Differentiation 50%
  • Programmed Death-Ligand 1 50%
  • Amino Acid 25%
  • Downregulation 25%

• Heterozygous P32/C1QBP/HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas

  Raschdorf, A., Sünderhauf, A., Skibbe, K., Ghebrehiwet, B., Peerschke, E. I., Sina, C. & Derer, S., 08.02.2021, In: Frontiers in Oncology. 10, p. 631592 631592.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Oxidative Phosphorylation 100%
  • Single-Nucleotide Polymorphism 75%
  • Protein 25%
  • Conformational Change 25%
  • Cell Proliferation 25%

• Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis

  Sünderhauf, A., Hicken, M., Schlichting, H., Skibbe, K., Ragab, M., Raschdorf, A., Hirose, M., Schäffler, H., Bokemeyer, A., Bettenworth, D., Savitt, A. G., Perner, S., Ibrahim, S., Peerschke, E. I., Ghebrehiwet, B., Derer, S. & Sina, C., 01.2021, In: CMGH. 12, 1, p. 229-250 22 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cellular Differentiation 100%
  • Cell Differentiation 100%
  • Mucus 33%
  • Mouse Mutant 22%
  • Glycolysis 22%
  1 Citation (Scopus)

• Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3⁺RORγt⁺IL-17⁺ Tregs and improve metabolism

  Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A. L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L. & Åkesson, C. P. & 5 others, Agace, W., Sina, C., Kleiveland, C. R., Kristiansen, K. & Lea, T. E., 17.02.2021, In: Nature Communications. 12, 1, p. 1093 1093.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T Cell 100%
  • Intestine Flora 100%
  • Interleukin 17 100%
  • Methylococcus capsulatus 100%
  • Methylococcus 66%
• 2020

  GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

  Sünderhauf, A., Raschdorf, A., Hicken, M., Schlichting, H., Fetzer, F., Brethack, A. K., Perner, S., Kemper, C., Ghebrehiwet, B., Sina, C. & Derer, S., 30.09.2020, In: Frontiers in Oncology. 10, 575854.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Oxidative Phosphorylation 100%
  • Cell Proliferation 66%
  • Glycolysis 66%
  • Binding Protein 33%
  • Translation (Protein Synthesis) 33%

• Inflammatory Bowel Disease-associated GP2 Autoantibodies Inhibit Mucosal Immune Response to Adherent-invasive Bacteria

  Derer, S., Brethack, A. K., Pietsch, C., Jendrek, S. T., Nitzsche, T., Bokemeyer, A., Hov, J. R., Schäffler, H., Bettenworth, D., Grassl, G. A. & Sina, C., 01.12.2020, In: Inflammatory Bowel Diseases. 26, 12, p. 1856-1868 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Bacterium 100%
  • Mucosal Immune Response 100%
  • Tumor Necrosis Factor 22%
  • Epithelium 11%
  • Enteritis 11%

• Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From Triticum aestivum in Drosophila melanogaster

  Thiel, A. L., Ragab, M., Wagner, A. E., Divanovic, S., Derer, S. & Sina, C., 23.12.2020, In: Frontiers in Nutrition. 7, 607937.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Amylase 100%
  • Purification 100%
  • Soluble Protein 100%
  • Glucosidase 80%
  • Koji 71%

• Saccharin supplementation inhibits bacterial growth and reduces experimental colitis in mice

  Sünderhauf, A., Pagel, R., Künstner, A., Wagner, A. E., Rupp, J., Ibrahim, S. M., Derer, S. & Sina, C., 17.04.2020, In: Nutrients. 12, 4, 1122.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Microbiome 100%
  • Enteritis 100%
  • Real-Time Polymerase Chain Reaction 50%
  • Intestine Flora 50%
  • Bacterial Count 50%
• 2019

  Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?

  Föh, B., Schröder, T., Oster, H., Derer, S. & Sina, C., 09.05.2019, In: Frontiers in medicine. 6, p. 103

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Inflammatory Bowel Disease 100%
  • Pathogenesis 50%
  • Apoplexy 50%
  • Intestinal Mucosal Barrier 50%
  • Ulcerative Colitis 50%

• Short-term high-fat diet feeding protects from the development of experimental allergic asthma in mice

  Schröder, T., Wiese, A. V., Ender, F., Quell, K. M., Vollbrandt, T., Duhn, J., Sünderhauf, A., Künstner, A., Moreno-Fernandez, M. E., Derer, S., Aherrahrou, Z., Lewkowich, I., Divanovic, S., Sina, C., Köhl, J. & Laumonnier, Y., 01.09.2019, In: Clinical and Experimental Allergy. 49, 9, p. 1245-1257 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Allergic Asthma 100%
  • Differentiation 50%
  • Airway 50%
  • Respiratory Tract Allergy 50%
  • Pulmonary Inflammation 33%
  2 Citations (Scopus)
• 2018

  Dietary ursolic acid improves health span and life span in male Drosophila melanogaster

  Staats, S., Wagner, A. E., Lüersen, K., Künstner, A., Meyer, T., Kahns, A. K., Derer, S., Graspeuntner, S., Rupp, J., Busch, H., Sina, C., Ipharraguerre, I. R. & Rimbach, G., 2018, In: BioFactors.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Drosophila melanogaster 100%
  • Microflora 50%
  • Mutant 25%
  • Homeostasis 25%
  • Gene 25%
• 2017

  Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis

  Jendrek, S. T., Gotthardt, D., Nitzsche, T., Widmann, L., Korf, T., Michaels, M. A., Weiss, K. H., Liaskou, E., Vesterhus, M., Karlsen, T. H., Mindorf, S., Schemmer, P., Bär, F., Teegen, B., Schröder, T., Ehlers, M., Hammers, C. M., Komorowski, L., Lehnert, H. & Fellermann, K. & 3 others, Derer, S., Hov, J. R. & Sina, C., 01.01.2017, In: Gut. 66, 1, p. 137-144 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Primary Sclerosing Cholangitis 100%
  • Patient 53%
  • Serum 7%
  • Evaluation 7%
  • Marker 7%
  12 Citations (Scopus)

• Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

  Pagel, R., Bär, F., Schröder, T., Sünderhauf, A., Künstner, A., Ibrahim, S. M., Autenrieth, S. E., Kalies, K., König, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S. & Sina, C., 01.01.2017, In: FASEB Journal. 31, 11, p. 4707-4719 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Death 100%
  • Chronic Inflammation 100%
  • Circadian Rhythm 100%
  • Homeostasis 100%
  • Inflammation 100%
  6 Citations (Scopus)

• Modulation der intestinalen Mikrobiota durch Ernährungsinterventionen

  Translated title of the contribution: Modulation of the intestinal microbiota by nutritional interventionsDerer, S., Lehnert, H., Sina, C. & Wagner, A. E., 01.05.2017, In: Internist. 58, 5, p. 435-440 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Nutritional Intervention 100%
  • Gut 100%
  • Plant-Based Food 100%
  • Dietary Fiber 100%
  • Vitamin 100%

• Monoclonal antibodies against epidermal growth factor receptor acquire an ability to kill tumor cells through complement activation by mutations that selectively facilitate the hexamerization of IgG on opsonized cells

  Tammen, A., Derer, S., Schwanbeck, R., Rösner, T., Kretschmer, A., Beurskens, F. J., Schuurman, J., Parren, P. W. H. I. & Valerius, T., 15.02.2017, In: Journal of Immunology. 198, 4, p. 1585-1594 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Complement Dependent Cytotoxicity 100%
  • Complement Activation 100%
  • Epidermal Growth Factor 100%
  • Monoclonal Antibody 100%
  • Complement Component C1q 80%
  10 Citations (Scopus)

• Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?

  Sünderhauf, A., Skibbe, K., Preisker, S., Ebbert, K., Verschoor, A., Karsten, C. M., Kemper, C., Huber-Lang, M., Basic, M., Bleich, A., Büning, J., Fellermann, K., Sina, C. & Derer, S., 10.2017, In: Molecular Immunology. 90, p. 227-238 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Intestine 100%
  • Bacterium 75%
  • TLR2 50%
  • Complement System 50%
  • Cell Line 25%
• 2016

  An anti-EGFR IgA that displays improved pharmacokinetics and myeloid effector cell engagement in vivo

  Lohse, S., Meyer, S., Meulenbroek, L. A. P. M., Jansen, J. H. M., Nederend, M., Kretschmer, A., Klausz, K., Möginger, U., Derer, S., Rösner, T., Kellner, C., Schewe, D., Sondermann, P., Tiwari, S., Kolarich, D., Peipp, M., Leusen, J. H. W. & Valerius, T., 15.01.2016, In: Cancer Research. 76, 2, p. 403-417 15 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Effector Cell 100%
  • Immunoglobulin A Antibody 50%
  • Modulation 25%
  • Cancer Cell 25%
  • Preclinical Study 25%
  28 Citations (Scopus)

• Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30

  Kellner, C., Günther, A., Humpe, A., Repp, R., Klausz, K., Derer, S., Valerius, T., Ritgen, M., Brüggemann, M., van de Winkel, J. G. J., Parren, P. W. H. I., Kneba, M., Gramatzki, M. & Peipp, M., 2016, In: OncoImmunology. 5, 1

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  • Therapeutic Antibodies 100%
  • Lymphoma Cell 100%
  • CD20 100%
  • NKG2D 100%
  12 Citations (Scopus)

• Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis

  Schröder, T., Kucharczyk, D., Bär, F., Pagel, R., Derer, S., Jendrek, S. T., Sünderhauf, A., Brethack, A. K., Hirose, M., Möller, S., Künstner, A., Bischof, J., Weyers, I., Heeren, J., Koczan, D., Schmid, S. M., Divanovic, S., Giles, D. A., Adamski, J. & Fellermann, K. & 4 others, Lehnert, H., Köhl, J., Ibrahim, S. & Sina, C., 01.04.2016, In: Molecular Metabolism. 5, 4, p. 283-295 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Energy Metabolism 100%
  • Mitochondrial Disorder 100%
  • Gene Polymorphism 100%
  • Cell Energy 100%
  • Nonalcoholic Fatty Liver 100%
  15 Citations (Scopus)

• Type i CD20 antibodies recruit the B cell receptor for complement-dependent lysis of malignant B cells

  Engelberts, P. J., Voorhorst, M., Schuurman, J., Van Meerten, T., Bakker, J. M., Vink, T., Mackus, W. J. M., Breij, E. C. W., Derer, S., Valerius, T., Van De Winkel, J. G. J., Parren, P. W. H. I. & Beurskens, F. J., 15.12.2016, In: Journal of Immunology. 197, 12, p. 4829-4837 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Complement Dependent Cytotoxicity 100%
  • B-Cell Receptor 100%
  • CD20 Antibody 100%
  • CD20 75%
  • Cell Line 25%
  17 Citations (Scopus)
• 2015

  A complement-optimized EGFR antibody improves cytotoxic functions of polymorphonuclear cells against tumor cells

  Derer, S., Cossham, M., Rösner, T., Kellner, C., Beurskens, F. J., Schwanbeck, R., Lohse, S., Sina, C., Peipp, M. & Valerius, T., 15.11.2015, In: Journal of Immunology. 195, 10, p. 5077-5087 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor Receptor Antibody 100%
  • Granulocyte 100%
  • Complement Dependent Cytotoxicity 44%
  • Mononuclear Cell 44%
  • Cell Mediated Cytotoxicity 44%
  8 Citations (Scopus)

• HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibodydependent cell-mediated cytotoxicity

  Peipp, M., Derer, S., Lohse, S., Staudinger, M., Klausz, K., Valerius, T., Gramatzki, M. & Kellner, C., 2015, In: Oncotarget. 6, 31, p. 32075-32088 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor Receptor 100%
  • Natural Killer Cell 100%
  • Epidermal Growth Factor Receptor 2 100%
  • Gamma Urogastrone 100%
  • Single Chain Fragment Variable Antibody 82%
  13 Citations (Scopus)

• Pancreatic Autoantibodies Against CUZD1 and GP2 Are Associated with Distinct Clinical Phenotypes of Crohn's Disease

  Michaels, M. A., Jendrek, S. T., Korf, T., Nitzsche, T., Teegen, B., Komorowski, L., Derer, S., Schröder, T., Baer, F., Lehnert, H., Büning, J., Fellerman, K. & Sina, C., 06.08.2015, In: Inflammatory Bowel Diseases. 21, 12, p. 2864-2872 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Serotype 50%
  25 Citations (Scopus)

• The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA′ enables screening of antibodies for immunotoxin development

  Klausz, K., Kellner, C., Derer, S., Valerius, T., Staudinger, M., Burger, R., Gramatzki, M. & Peipp, M., 03.2015, In: Journal of Immunological Methods. 418, p. 75-83 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Exotoxin 100%
  • Pseudomonas 100%
  • Immunotoxin 100%
  • Light Chain 16%
  • Cancer Cell 8%
  1 Citation (Scopus)
• 2014

  Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions

  Kellner, C., Derer, S., Valerius, T. & Peipp, M., 01.01.2014, In: Methods. 65, 1, p. 105-113 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Complement Dependent Cytotoxicity 100%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  • Monoclonal Antibody 40%
  • Amino Acid 20%
  • Vertebral Column 20%
  43 Citations (Scopus)

• Complement in antibody-based tumor therapy

  Derer, S., Beurskens, F. J., Rösner, T., Peipp, M. & Valerius, T., 2014, In: Critical Reviews in Immunology. 34, 3, p. 199-214 16 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Complement Dependent Cytotoxicity 100%
  • Therapeutic Antibodies 60%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 40%
  • Recognition 20%
  • Complement Activation 20%
  20 Citations (Scopus)

• Epidermal growth factor receptor targeting IgG3 triggers complement-mediated lysis of decay-accelerating factor expressing tumor cells through the alternative pathway amplification loop

  Rösner, T., Lohse, S., Peipp, M., Valerius, T. & Derer, S., 01.08.2014, In: Journal of Immunology. 193, 3, p. 1485-1495 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin G3 100%
  • Epidermal Growth Factor 100%
  • Decay-Accelerating Factor 100%
  • Complement Component C1q 45%
  • Immunoglobulin G1 36%
  12 Citations (Scopus)

• Increasing FcaγRIIa affinity of an FcaγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity

  Derer, S., Glorius, P., Schlaeth, M., Lohse, S., Klausz, K., Muchhal, U., Desjarlais, J. R., Humpe, A., Valerius, T. & Peipp, M., 2014, In: mAbs. 6, 2, p. 409-421 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor Receptor 100%
  • Cytotoxicity 100%
  • Antibody Dependent Cellular Cytotoxicity 100%
  • Neutrophil 100%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  27 Citations (Scopus)
• 2013

  Antibody-dependent cellular cytotoxicity in patients on chronic hemodialysis

  Koch, T., Derer, S., Staudinger, M., Rossen, K., Glorius, P., Peipp, M., Kellner, C., Kunzendorf, U., Valerius, T. & Dechant, M., 11.2013, In: American Journal of Nephrology. 38, 5, p. 379-387 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  • Hemodialysis 100%
  • Cell Mediated Cytotoxicity 100%
  • Monocyte 57%
  • Immunoglobulin G2 57%
  3 Citations (Scopus)

• Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2 min(1) antibody

  Brunke, C., Lohse, S., Derer, S., Peipp, M., Boross, P., Kellner, C., Beyer, T., Dechant, M., Royle, L., Liew, L. P., Leusen, J. H. & Valerius, T., 2013, In: mAbs. 5, 6, p. 936-945 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor 100%
  • Cysteine 100%
  • Immunoglobulin A Antibody 44%
  • Carboxy Terminal Sequence 22%
  • J Chain 22%
  11 Citations (Scopus)

• EGFR expression levels affect the mode of action of egfr-targeting monoclonal antibodies

  Derer, S., Lohse, S. & Valerius, T., 05.2013, In: OncoImmunology. 2, 5, e24052.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Monoclonal Antibody 100%
  • Antibody 28%
  • Receptor Density 14%
  • Cell Killing 14%
  5 Citations (Scopus)

• MTNF reverse signalling induced by TNFa antagonists involves a GDF-1 dependent pathway: Implications for Crohn's disease

  Derer, S., Till, A., Haesler, R., Sina, C., Grabe, N., Jung, S., Nikolaus, S., Kuehbacher, T., Groetzinger, J., Rose-John, S., Rosenstiel, P. C. & Schreiber, S., 01.03.2013, In: Gut. 62, 3, p. 376-386 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Crohn's Disease 100%
  • Differentiation 100%
  • Growth 100%
  • Certolizumab Pegol 50%
  • Mechanism of Action 25%
  26 Citations (Scopus)
• 2012

  Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages

  Lohse, S., Brunke, C., Derer, S., Peipp, M., Boross, P., Kellner, C., Beyer, T., Dechant, M., Van Der Winkel, J. G. J., Leusen, J. H. W. & Valerius, T., 20.07.2012, In: Journal of Biological Chemistry. 287, 30, p. 25139-25150 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Macrophage 100%
  • Epidermal Growth Factor 100%
  • Monocyte 100%
  • Allotype 100%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 60%
  24 Citations (Scopus)

• Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies

  Derer, S., Bauer, P., Lohse, S., Scheel, A. H., Berger, S., Kellner, C., Peipp, M. & Valerius, T., 01.12.2012, In: Journal of Immunology. 189, 11, p. 5230-5239 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Surface 100%
  • Epidermal Growth Factor 100%
  • Epidermal Growth Factor Receptor Antibody 100%
  • Cell Mediated Cytotoxicity 17%
  • Lung 11%
  44 Citations (Scopus)

• Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression

  Derer, S., Berger, S., Schlaeth, M., Schneider-Merck, T., Klausz, K., Lohse, S., Overdijk, M. B., Dechant, M., Kellner, C., Nagelmeier, I., Scheel, A. H., van Bueren, J. J. L., van de Winkel, J. G. J., Parren, P. W. H. I., Peipp, M. & Valerius, T., 03.2012, In: Neoplasia. 14, 3, p. 190-205 16 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • KRAS 100%
  • Ccaat-Enhancer-Binding Proteins 100%
  • Epidermal Growth Factor 100%
  • CCAAT Enhancer Binding Protein 100%
  • Experiment 15%
  15 Citations (Scopus)
• 2011

  Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII)

  Klausz, K., Berger, S., Lammerts van Bueren, J. J., Derer, S., Lohse, S., Dechant, M., van de Winkel, J. G. J., Peipp, M., Parren, P. W. H. I. & Valerius, T., 10.2011, In: Cancer Science. 102, 10, p. 1761-1768 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor 100%
  • Monoclonal Antibody 100%
  • Cytolysis 100%
  • Zalutumumab 83%
  • Complement Dependent Cytotoxicity 33%
  20 Citations (Scopus)

• Human kappa light chain targeted Pseudomonas exotoxin A - identifying human antibodies and Fab fragments with favorable characteristics for antibody-drug conjugate development

  Kellner, C., Bleeker, W. K., Lammerts van Bueren, J. J., Staudinger, M., Klausz, K., Derer, S., Glorius, P., Muskulus, A., de Goeij, B. E. C. G., van de Winkel, J. G. J., Parren, P. W. H. I., Valerius, T., Gramatzki, M. & Peipp, M., 31.08.2011, In: Journal of Immunological Methods. 371, 1-2, p. 122-133 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Light Chain 100%
  • Exotoxin 100%
  • Pseudomonas 100%
  • Immunoglobulin F(ab) Fragment 100%
  • Antibody Drug Conjugate 100%
  15 Citations (Scopus)

• Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing

  Lohse, S., Derer, S., Beyer, T., Klausz, K., Peipp, M., Leusen, J. H. W., Van De Winkel, J. G. J., Dechant, M. & Valerius, T., 15.03.2011, In: Journal of Immunology. 186, 6, p. 3770-3778 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Killing 100%
  • Copurification 20%
  • Dimer 11%
  • Electron Affinity 11%
  • Homo sapiens 11%
  45 Citations (Scopus)
• 2010

  Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells

  Schlaeth, M., Berger, S., Derer, S., Klausz, K., Lohse, S., Dechant, M., Lazar, G. A., Schneider-Merck, T., Peipp, M. & Valerius, T., 05.2010, In: Cancer Science. 101, 5, p. 1080-1088 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • KRAS 100%
  • Epidermal Growth Factor Receptor 100%
  • Antibody Dependent Cellular Cytotoxicity 100%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  • Epidermal Growth Factor Receptor Antibody 100%
  32 Citations (Scopus)

• Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage

  Schneider-Merck, T., Van Lammerts Bueren, J. J., Berger, S., Rossen, K., Van Berkel, P. H. C., Derer, S., Beyer, T., Lohse, S., Bleeker, W. K., Peipp, M., Parren, P. W. H. I., Van De Winkel, J. G. J., Valerius, T. & Dechant, M., 01.01.2010, In: Journal of Immunology. 184, 1, p. 512-520 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Epidermal Growth Factor 100%
  • Immunoglobulin G1 100%
  • Antibody-Dependent Cell-Mediated Cytotoxicity 100%
  • Cell Mediated Cytotoxicity 100%
  • Immunoglobulin G2 100%
  154 Citations (Scopus)
• 2009

  G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation

  Sina, C., Gavrilova, O., Fórster, M., Till, A., Derer, S., Hildebrand, F., Raabe, B., Chalaris, A., Scheller, J., Rehmann, A., Franke, A., Ott, S., Hásler, R., Nikolaus, S., Fólsch, U. R., Rose-John, S., Jiang, H. P., Li, J., Schreiber, S. & Rosenstiel, P., 01.12.2009, In: Journal of Immunology. 183, 11, p. 7514-7522 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Neutrophil 100%
  • Granulocyte 100%
  • Enteritis 100%
  • Experiment 12%
  • Inflammation 12%
  217 Citations (Scopus)
• 2008

  Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes

  Rosenstiel, P., Derer, S., Till, A., Häsler, R., Eberstein, H., Bewig, B., Nikolaus, S., Nebel, A. & Schreiber, S., 03.2008, In: Genes and Immunity. 9, 2, p. 103-114 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunosenescence 100%
  • Toll-Like Receptor 66%
  • Recognition 33%
  • Immunocompetent Cell 33%
  • Downregulation 33%
  26 Citations (Scopus)