Rudolf Manz

Research output

Research Output per year 1995 2002 2005 2006 2007 2009 2011 2012 2013 2014 2016 2018 2023

• 65 Journal articles
• 13 Scientific review articles
• 3 Chapter
• 2 Letters
• 1 More
  • 1 Comments/Debates

Research Output per year

Research Output per year

Search results

• 2023

  IgE-Mast cell mediated allergy: a sensor of food quality

  Udoye, C. C. & Manz, R. A., 12.2023, In: Signal Transduction and Targeted Therapy. 8, 1, 446.

  Research output: Journal Articles › Journal articles › Research › peer-review
• 2022

  B-cell receptor physical properties affect relative IgG1 and IgE responses in mouse egg allergy.

  Manz, R., 06.2022, In: Mucosal Immunology. 15, 6, p. 1375-1388 14 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin G1 100%
  • Immunoglobulin E 100%
  • B-Cell Receptor 100%
  • Egg Allergy 100%
  • Binding Antibody 10%
• 2021

  Dual role of interleukin‐10 in murine nzb/w f1 lupus

  Amend, A., Wickli, N., Schäfer, A. L., Sprenger, D. T. L., Manz, R. A., Voll, R. E. & Chevalier, N., 29.01.2021, In: International Journal of Molecular Sciences. 22, 3, p. 1-24 24 p., 1347.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lupus Erythematosus 100%
  • B Cell 40%
  • Immunocompetent Cell 20%
  • Immunoglobulin Producing Cell 20%
  • Autoimmune Disease 20%
• 2020

  IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease

  Clauder, A. K., Kordowski, A., Bartsch, Y. C., Köhl, G., Lilienthal, G. M., Almeida, L. N., Lindemann, T., Petry, J., Rau, C. N., Gramalla-Schmitz, A., Dühring, L., Elbracht, C., Kenno, S., Tillmann, J., Wuhrer, M., Ludwig, R. J., Ibrahim, S. M., Bieber, K., Köhl, J. & Ehlers, M. & 1 others, Manz, R. A., 2020, In: Journal of Investigative Dermatology.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Glycosylation 100%
  • Haplotype 100%
  • Autoimmune Skin Disease 100%
  • Autoimmune Disease 75%
  • Major Histocompatibility Complex 75%

• IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

  Bartsch, Y. C., Eschweiler, S., Leliavski, A., Lunding, H. B., Wagt, S., Petry, J., Lilienthal, G. M., Rahmöller, J., de Haan, N., Hölscher, A., Erapaneedi, R., Giannou, A. D., Aly, L., Sato, R., de Neef, L. A., Winkler, A., Braumann, D., Hobusch, J., Kuhnigk, K. & Krémer, V. & 19 others, Steinhaus, M., Blanchard, V., Gemoll, T., Habermann, J. K., Collin, M., Salinas, G., Manz, R. A., Fukuyama, H., Korn, T., Waisman, A., Yogev, N., Huber, S., Rabe, B., Rose-John, S., Busch, H., Berberich-Siebelt, F., Hölscher, C., Wuhrer, M. & Ehlers, M., 09.2020, In: Journal of Allergy and Clinical Immunology. 146, 3, p. 652-666.e11

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Germinal Center 100%
  • Adjuvant 100%
  • Sialylation 100%
  • Glycosylation 85%
  • B Cell 42%
  1 Citation (Scopus)

• IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice

  Link, C. W. M., Rau, C. N., Udoye, C. C., Ragab, M., Korkmaz, R. Ü., Comdühr, S., Clauder, A.-K., Lindemann, T., Frehse, B., Hofmann, K., Almeida, L. N., Laumonnier, Y., Beidaq, A. E., Finkelman, F. D. & Manz, R. A., 2020, In: Frontiers in Immunology. 11, p. 596772

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Agonist 100%
  • Food Allergen 100%
  • Interleukin 2 100%
  • Systemic Anaphylaxis 100%
  • Allergen 80%
• 2019

  Bone Marrow Plasma Cells Modulate Local Myeloid-Lineage Differentiation via IL-10

  Meng, L., Almeida, L. N., Clauder, A.-K., Lindemann, T., Luther, J., Link, C., Hofmann, K., Kulkarni, U., Wong, D. M., David, J.-P. & Manz, R. A., 01.01.2019, In: Frontiers in Immunology. 10, MAY, p. 1183 1183.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Interleukin 10 100%
  • Lineage 100%
  • Myeloid 100%
  • CD11c 16%

• Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

  Vorobyev, A., Gupta, Y., Sezin, T., Koga, H., Bartsch, Y. C., Belheouane, M., Künzel, S., Sina, C., Schilf, P., Körber-Ahrens, H., Beltsiou, F., Lara Ernst, A., Khil'chenko, S., Al-Aasam, H., Manz, R. A., Diehl, S., Steinhaus, M., Jascholt, J., Kouki, P. & Boehncke, W.-H. & 10 others, Mayadas, T. N., Zillikens, D., Sadik, C. D., Nishi, H., Ehlers, M., Möller, S., Bieber, K., Baines, J. F., Ibrahim, S. M. & Ludwig, R. J., 01.12.2019, In: Nature Communications. 10, 1, p. 4097 4097.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoimmunity 100%
  • Genetic Susceptibility 66%
  • Quantitative Trait Locus 33%
  • Genetic Predisposition 33%
  • Whole Genome Sequencing 33%

• Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

  Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W., Aghaeepour, N., Akdis, M., Allez, M., Almeida, L. N., Alvisi, G., Anderson, G., Andrä, I., Annunziato, F., Anselmo, A., Bacher, P., Baldari, C. T., Bari, S. & Barnaba, V. & 416 others, Barros-Martins, J., Battistini, L., Bauer, W., Baumgart, S., Baumgarth, N., Baumjohann, D., Baying, B., Bebawy, M., Becher, B., Beisker, W., Benes, V., Beyaert, R., Blanco, A., Boardman, D. A., Bogdan, C., Borger, J. G., Borsellino, G., Boulais, P. E., Bradford, J. A., Brenner, D., Brinkman, R. R., Brooks, A. E. S., Busch, D. H., Büscher, M., Bushnell, T. P., Calzetti, F., Cameron, G., Cammarata, I., Cao, X., Cardell, S. L., Casola, S., Cassatella, M. A., Cavani, A., Celada, A., Chatenoud, L., Chattopadhyay, P. K., Chow, S., Christakou, E., Čičin-Šain, L., Clerici, M., Colombo, F. S., Cook, L., Cooke, A., Cooper, A. M., Corbett, A. J., Cosma, A., Cosmi, L., Coulie, P. G., Cumano, A., Cvetkovic, L., Dang, V. D., Dang-Heine, C., Davey, M. S., Davies, D., De Biasi, S., Del Zotto, G., Dela Cruz, G. V., Delacher, M., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Di Santo, J. P., Diefenbach, A., Dieli, F., Dolf, A., Dörner, T., Dress, R. J., Dudziak, D., Dustin, M., Dutertre, C. A., Ebner, F., Eckle, S. B. G., Edinger, M., Eede, P., Ehrhardt, G. R. A., Eich, M., Engel, P., Engelhardt, B., Erdei, A., Esser, C., Everts, B., Evrard, M., Falk, C. S., Fehniger, T. A., Felipo-Benavent, M., Ferry, H., Feuerer, M., Filby, A., Filkor, K., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frehse, B., Frenette, P. S., Frischbutter, S., Fritzsche, W., Galbraith, D. W., Gangaev, A., Garbi, N., Gaudilliere, B., Gazzinelli, R. T., Geginat, J., Gerner, W., Gherardin, N. A., Ghoreschi, K., Gibellini, L., Ginhoux, F., Goda, K., Godfrey, D. I., Goettlinger, C., González-Navajas, J. M., Goodyear, C. S., Gori, A., Grogan, J. L., Grummitt, D., Grützkau, A., Haftmann, C., Hahn, J., Hammad, H., Hämmerling, G., Hansmann, L., Hansson, G., Harpur, C. M., Hartmann, S., Hauser, A., Hauser, A. E., Haviland, D. L., Hedley, D., Hernández, D. C., Herrera, G., Herrmann, M., Hess, C., Höfer, T., Hoffmann, P., Hogquist, K., Holland, T., Höllt, T., Holmdahl, R., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Huang, F. P., Huber, J. E., Huehn, J., Hundemer, M., Hunter, C. A., Hwang, W. Y. K., Iannone, A., Ingelfinger, F., Ivison, S. M., Jäck, H. M., Jani, P. K., Jávega, B., Jonjic, S., Kaiser, T., Kalina, T., Kamradt, T., Kaufmann, S. H. E., Keller, B., Ketelaars, S. L. C., Khalilnezhad, A., Khan, S., Kisielow, J., Klenerman, P., Knopf, J., Koay, H. F., Kobow, K., Kolls, J. K., Kong, W. T., Kopf, M., Korn, T., Kriegsmann, K., Kristyanto, H., Kroneis, T., Krueger, A., Kühne, J., Kukat, C., Kunkel, D., Kunze-Schumacher, H., Kurosaki, T., Kurts, C., Kvistborg, P., Kwok, I., Landry, J., Lantz, O., Lanuti, P., LaRosa, F., Lehuen, A., LeibundGut-Landmann, S., Leipold, M. D., Leung, L. Y. T., Levings, M. K., Lino, A. C., Liotta, F., Litwin, V., Liu, Y., Ljunggren, H. G., Lohoff, M., Lombardi, G., Lopez, L., López-Botet, M., Lovett-Racke, A. E., Lubberts, E., Luche, H., Ludewig, B., Lugli, E., Lunemann, S., Maecker, H. T., Maggi, L., Maguire, O., Mair, F., Mair, K. H., Mantovani, A., Manz, R. A., Marshall, A. J., Martínez-Romero, A., Martrus, G., Marventano, I., Maslinski, W., Matarese, G., Mattioli, A. V., Maueröder, C., Mazzoni, A., McCluskey, J., McGrath, M., McGuire, H. M., McInnes, I. B., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Miller, S. D., Mills, K. H. G., Minderman, H., Mjösberg, J., Moore, J., Moran, B., Moretta, L., Mosmann, T. R., Müller, S., Multhoff, G., Muñoz, L. E., Münz, C., Nakayama, T., Nasi, M., Neumann, K., Ng, L. G., Niedobitek, A., Nourshargh, S., Núñez, G., O'Connor, J. E., Ochel, A., Oja, A., Ordonez, D., Orfao, A., Orlowski-Oliver, E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Pattanapanyasat, K., Paulsen, M., Pavlinic, D., Penter, L., Peterson, P., Peth, C., Petriz, J., Piancone, F., Pickl, W. F., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Poon, Z., Pracht, K., Prinz, I., Pucillo, C. E. M., Quataert, S. A., Quatrini, L., Quinn, K. M., Radbruch, H., Radstake, T. R. D. J., Rahmig, S., Rahn, H. P., Rajwa, B., Ravichandran, G., Raz, Y., Rebhahn, J. A., Recktenwald, D., Reimer, D., Reis e Sousa, C., Remmerswaal, E. B. M., Richter, L., Rico, L. G., Riddell, A., Rieger, A. M., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Saalmüller, A., Saeys, Y., Saito, T., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sandrock, I., Santoni, A., Sanz, R. B., Saresella, M., Sautes-Fridman, C., Sawitzki, B., Schadt, L., Scheffold, A., Scherer, H. U., Schiemann, M., Schildberg, F. A., Schimisky, E., Schlitzer, A., Schlosser, J., Schmid, S., Schmitt, S., Schober, K., Schraivogel, D., Schuh, W., Schüler, T., Schulte, R., Schulz, A. R., Schulz, S. R., Scottá, C., Scott-Algara, D., Sester, D. P., Shankey, T. V., Silva-Santos, B., Simon, A. K., Sitnik, K. M., Sozzani, S., Speiser, D. E., Spidlen, J., Stahlberg, A., Stall, A. M., Stanley, N., Stark, R., Stehle, C., Steinmetz, T., Stockinger, H., Takahama, Y., Takeda, K., Tan, L., Tárnok, A., Tiegs, G., Toldi, G., Tornack, J., Traggiai, E., Trebak, M., Tree, T. I. M., Trotter, J., Trowsdale, J., Tsoumakidou, M., Ulrich, H., Urbanczyk, S., van de Veen, W., van den Broek, M., van der Pol, E., Van Gassen, S., Van Isterdael, G., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H. D., von Borstel, A., von Volkmann, K., Waisman, A., Walker, R. V., Wallace, P. K., Wang, S. A., Wang, X. M., Ward, M. D., Ward-Hartstonge, K. A., Warnatz, K., Warnes, G., Warth, S., Waskow, C., Watson, J. V., Watzl, C., Wegener, L., Weisenburger, T., Wiedemann, A., Wienands, J., Wilharm, A., Wilkinson, R. J., Willimsky, G., Wing, J. B., Winkelmann, R., Winkler, T. H., Wirz, O. F., Wong, A., Wurst, P., Yang, J. H. M., Yang, J., Yazdanbakhsh, M., Yu, L., Yue, A., Zhang, H., Zhao, Y., Ziegler, S. M., Zielinski, C., Zimmermann, J. & Zychlinsky, A., 01.10.2019, In: European Journal of Immunology. 49, 10, p. 1457-1973 517 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunocompetent Cell 100%
  • Human Cell 100%
  • Cell Selection 100%
• 2018

  A novel role for C5a in B-1 cell homeostasis

  Bröker, K., Figge, J., Magnusen, A. F., Manz, R. A., Köhl, J. & Karsten, C. M., 19.02.2018, In: Frontiers in Immunology. 9, FEB, 258.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Complement Component 5a 100%
  • B-1 Cell 100%
  • Homeostasis 100%
  • Peritoneal Cavity 77%
  • CXCL13 55%
• 2016

  Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice

  Srikakulapu, P., Hu, D., Yin, C., Mohanta, S. K., Bontha, S. V., Peng, L., Beer, M., Weber, C., McNamara, C. A., Grassia, G., Maffia, P., Manz, R. A. & Habenicht, A. J. R., 06.2016, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 6, p. 1174-85 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Artery 100%
  • Lymphoid Organ 100%
  • Atherosclerosis 100%
  • Apolipoprotein E Knockout Mouse 100%
  • B Cell 100%

• IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration

  Kulkarni, U., Karsten, C. M., Kohler, T., Hammerschmidt, S., Bommert, K., Tiburzy, B., Meng, L., Thieme, L., Recke, A., Ludwig, R. J., Pollok, K., Kalies, K., Bogen, B., Boettcher, M., Kamradt, T., Hauser, A. E., Langer, C., Huber-Lang, M., Finkelman, F. D. & Köhl, J. & 2 others, Wong, D. M. & Manz, R. A., 01.05.2016, In: Journal of Allergy and Clinical Immunology. 137, 5, p. 1487-1497e6

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Neutrophil 100%
  • Interleukin 10 100%
  • Immunodeficiency 100%
  • Immunoglobulin Producing Cell 30%
  • Receptor Blocking 15%
  18 Citations (Scopus)

• In vivo expansion of endogenous regulatory t cell populations induces long-term suppression of contact hypersensitivity

  El Beidaq, A., Link, C. W. M., Hofmann, K., Frehse, B., Hartmann, K., Bieber, K., Martin, S. F., Ludwig, R. J. & Manz, R. A., 01.09.2016, In: Journal of Immunology. 197, 5, p. 1567-1576 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Population 100%
  • Regulatory T Cell 100%
  • Interleukin 2 87%
  • Hapten 50%
  • Cytotoxic T-Cell 37%
  2 Citations (Scopus)

• T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita

  Bieber, K., Witte, M., Sun, S., Hundt, J. E., Kalies, K., Dräger, S., Kasprick, A., Twelkmeyer, T., Manz, R. A., König, P., Köhl, J., Zillikens, D. & Ludwig, R. J., 05.12.2016, In: Scientific Reports. 6, 38357.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • T Cell 100%
  • Dermatitis 100%
  • Autoantibody 100%
  • Neutrophil 57%
  • Immune Complex 28%
  8 Citations (Scopus)
• 2015

  Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

  Taddeo, A., Khodadadi, L., Voigt, C., Mumtaz, I. M., Cheng, Q., Moser, K., Alexander, T., Manz, R. A., Radbruch, A., Hiepe, F. & Hoyer, B. F., 2015, In: Arthritis Research and Therapy. 17, p. 39

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Precursor 100%
  • Autoantibody 40%
  • Systemic Lupus Erythematosus 25%
  • Flow Cytometry 20%
• 2014

  Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa Acquisita

  Hirose, M., Tiburzy, B., Ishii, N., Pipi, E., Wende, S., Rentz, E., Nimmerjahn, F., Zillikens, D., Manz, R. A., Ludwig, R. J. & Kasperkiewicz, M., 2014, In: Journal of Investigative Dermatology. 135, 3, p. 768-75 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Intravenous Immunoglobulin 100%
  • Autoantibody 33%
  • Fc Receptor 11%
  • Innate Immune System 11%
  • Neutrophil Chemotaxis 11%

• Eosinophils and megakaryocytes support the early growth of murine MOPC315 myeloma cells in their bone marrow niches

  Wong, D., Winter, O., Hartig, C., Siebels, S., Szyska, M., Tiburzy, B., Meng, L., Kulkarni, U., Fähnrich, A., Bommert, K., Bargou, R., Berek, C., Chu, V. T., Bogen, B., Jundt, F. & Manz, R. A., 01.10.2014, In: PLoS ONE. 9, 10, 109018.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Eosinophil 100%
  • Myeloma Cell 100%
  • Myeloma 100%
  • Multiple Myeloma 71%
  • Immunoglobulin Producing Cell 71%
  16 Citations (Scopus)

• Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses

  Tukaj, S., Tiburzy, B., Manz, R., de Castro Marques, A., Orosz, A., Ludwig, R. J., Zillikens, D. & Kasperkiewicz, M., 01.01.2014, In: Experimental Dermatology. 23, 8, p. 585-590 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Humoral Immunity 100%
  • B Cell 85%
  • Autoantibody 57%
  • Regulatory B Cells 28%
  • T Cell 28%
  14 Citations (Scopus)

• Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

  Schwarzer, R., Nickel, N., Godau, J., Willie, B. M., Duda, G. N., Schwarzer, R., Cirovic, B., Leutz, A., Manz, R., Bogen, B., Dörken, B. & Jundt, F., 06.2014, In: Blood Cancer Journal. 4, 6, e217.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Notch 100%
  • Myeloma Bone Disease 100%
  • Multiple Myeloma 71%
  • Myeloma Cell 42%
  • In Vitro 28%
  25 Citations (Scopus)
• 2013

  B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita

  Iwata, H., Bieber, K., Tiburzy, B., Chrobok, N., Kalies, K., Shimizu, A., Leineweber, S., Ishiko, A., Vorobyev, A., Zillikens, D., Köhl, J., Westermann, J., Seeger, K., Manz, R. & Ludwig, R. J., 15.09.2013, In: Journal of Immunology. 191, 6, p. 2978-2988 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Macrophage 100%
  • CD4 100%
  • T Helper Cell 100%
  • Autoantibody 100%
  • Dendritic Cell 100%
  26 Citations (Scopus)

• B-Zellen: Interaktionen und Antikörperproduktion

  Translated title of the contribution: B cells: Interactions and antibody productionTiburzy, B. & Manz, R. A., 05.2013, In: Zeitschrift fur Rheumatologie. 72, 4, p. 372-374 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

• Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisita

  Tiburzy, B., Szyska, M., Iwata, H., Chrobok, N., Kulkarni, U., Hirose, M., Ludwig, R. J., Kalies, K., Westermann, J., Wong, D. & Manz, R. A., 26.12.2013, In: PLoS ONE. 8, 12, A88.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Lymph Node 100%
  • Autoantibody 100%
  • T-Helper Cell 15%
  • Lifespan 15%
  8 Citations (Scopus)

• T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies

  Hess, C., Winkler, A., Lorenz, A. K., Holecska, V., Blanchard, V., Eiglmeier, S., Schoen, A. L., Bitterling, J., Stoehr, A. D., Petzold, D., Schommartz, T., Mertes, M. M. M., Schoen, C. T., Tiburzy, B., Herrmann, A., Köhl, J., Manz, R. A., Madaio, M. P., Berger, M. & Wardemann, H. & 1 others, Ehlers, M., 03.09.2013, In: Journal of Clinical Investigation. 123, 9, p. 3788-3796 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • B Cell Activation 100%
  • T Cell 100%
  • Immunoglobulin G 100%
  • Immunosuppressive Drug 100%
  • B-Cell Receptor 25%
  53 Citations (Scopus)
• 2012

  Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

  Mumtaz, I. M., Hoyer, B. F., Panne, D., Moser, K., Winter, O., Cheng, Q. Y., Yoshida, T., Burmester, G. R., Radbruch, A., Manz, R. A. & Hiepe, F., 09.2012, In: Journal of Autoimmunity. 39, 3, p. 180-188 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Dexamethasone 100%
  • Autoimmunity 100%
  • Plasmablast 15%
  • Memory Cell 15%
  51 Citations (Scopus)

• CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines

  Serre, K., Cunningham, A. F., Coughlan, R. E., Lino, A. C., Rot, A., Hub, E., Moser, K., Manz, R., Ferraro, A., Bird, R., Toellner, K. M., Demengeot, J., MacLennan, I. C. M. & Mohr, E., 29.11.2012, In: Blood. 120, 23, p. 4552-4559 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • CXCR3 100%
  • Cytotoxic T-Cell 100%
  • B Cell 100%
  • Immunoglobulin Producing Cell 71%
  • Germinal Center 57%
  22 Citations (Scopus)

• CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice.

  Moser, K., Kalies, K., Szyska, M., Humrich, J. Y., Amann, K. & Manz, R. A., 04.2012, In: Arthritis and Rheumatism. 64, 4, p. 1237-1246 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • CXCR3 100%
  • Immunoglobulin G1 100%
  • Lupus Erythematosus 100%
  • Nephritis 100%
  • Autoantibody 100%
  24 Citations (Scopus)

• Long-term bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice

  Wegmann, M., Lunding, L., Orinska, Z., Wong, D. M., Manz, R. A. & Fehrenbach, H., 04.2012, In: International Archives of Allergy and Immunology. 158, 1, p. 43-53 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Titer 100%
  • Immunoglobulin E 100%
  • Allergen 100%
  • Asthma 100%
  10 Citations (Scopus)
• 2011

  Antibody memory: a question of life or death beyond the germinal center

  Moser, K., Wong, D. M. & Manz, R. A., 02.2011, In: Immunology and Cell Biology. 89, 2, p. 164-6 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

• Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: Evidence that nonmalignant plasma cells are not therapeutic targets

  Kasperkiewicz, M., Müller, R., Manz, R., Magens, M., Hammers, C. M., Somlai, C., Westermann, J., Schmidt, E., Zillikens, D., Ludwig, R. J. & Orosz, A., 09.06.2011, In: Blood. 117, 23, p. 6135-6142 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoimmunity 100%
  • Immunoglobulin Producing Cell 100%
  • Collagen Type 7 100%
  • T Cell 33%
  • Autoantibody 33%
  36 Citations (Scopus)

• Myeloperoxidase-specific plasma cell depletion by bortezomib protects from anti-neutrophil cytoplasmic autoantibodies-induced glomerulonephritis

  Bontscho, J., Schreiber, A., Manz, R. A., Schneider, W., Luft, F. C. & Kettritz, R., 02.2011, In: Journal of the American Society of Nephrology. 22, 2, p. 336-348 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Neutrophil 100%
  • Myeloperoxidase 100%
  • Glomerulonephritis 100%
  • Autoantibody 100%
  53 Citations (Scopus)

• Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis

  Gomez, A. M., Vrolix, K., Martínez-Martínez, P., Molenaar, P. C., Phernambucq, M., Van Der Esch, E., Duimel, H., Verheyen, F., Voll, R. E., Manz, R. A., De Baets, M. H. & Losen, M., 15.02.2011, In: Journal of Immunology. 186, 4, p. 2503-2513 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Experimental Autoimmune Myasthenia Gravis 100%
  • Autoantibody 100%
  • Proteasome 100%
  • Titer 50%
  96 Citations (Scopus)
• 2010

  Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow

  Winter, O., Moser, K., Mohr, E., Zotos, D., Kaminski, H., Szyska, M., Roth, K., Wong, D. M., Dame, C., Tarlinton, D. M., Schulze, H., MacLennan, I. C. M. & Manz, R. A., 16.09.2010, In: Blood. 116, 11, p. 1867-1875 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Interleukin 6 12%
  • Immunity 12%
  • Wild Type Mouse 12%
  • Antigen Specificity 12%
  140 Citations (Scopus)
• 2009

  Blood-borne human plasma cells in steady state are derived from mucosal immune responses

  Mei, H. E., Yoshida, T., Sime, W., Hiepe, F., Thiele, K., Manz, R. A., Radbruch, A. & Dörner, T., 2009, In: Blood. 113, 11, p. 2461-9 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Mucosal Immune Response 100%
  • Blood Plasma 100%
  • Plasmablast 75%
  • Integrin 37%

• CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients

  Enghard, P., Humrich, J. Y., Rudolph, B., Rosenberger, S., Biesen, R., Kuhn, A., Manz, R., Hiepe, F., Radbruch, A., Burmester, G. R. & Riemekasten, G., 01.01.2009, In: Arthritis and Rheumatism. 60, 1, p. 199-206 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Biological Marker 100%
  • T-Helper Cell 100%
  • Nephritic Syndrome 100%
  • T Cell 57%
  • Lupus Nephritis 57%
  82 Citations (Scopus)

• Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature

  Mohr, E., Serre, K., Manz, R. A., Cunningham, A. F., Khan, M., Hardie, D. L., Bird, R. & MacLennan, I. C. M., 15.02.2009, In: Journal of Immunology. 182, 4, p. 2113-2123 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Macrophage 100%
  • Plasmablast 100%
  • Interleukin 6 100%
  • Lymph Node 100%
  • Dendritic Cell 100%
  140 Citations (Scopus)

• Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge

  Luger, E. O., Fokuhl, V., Wegmann, M., Abram, M., Tillack, K., Achatz, G., Manz, R. A., Worm, M., Radbruch, A. & Renz, H., 2009, In: Journal of Allergy and Clinical Immunology. 124, 4, p. 819-26.e4

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Allergen 100%
  • Immunoglobulin E 41%
  • Immunoglobulin A 41%
  • Exhalation 33%
• 2008

  Human mastoid periosteum-derived stem cells: Promising candidates for skeletal tissue engineering

  Ringe, J., Leinhase, I., Stich, S., Loch, A., Neumann, K., Haisch, A., Häupl, T., Manz, R., Kaps, C. & Sittinger, M., 03.2008, In: Journal of tissue engineering and regenerative medicine. 2, 2-3, p. 136-146 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Stem Cell 100%
  • Periosteum 100%
  • Mesenchymal Stem Cell 61%
  • Stem Cell Marker 25%
  • Fluorescence Activated Cell Sorting 12%
  52 Citations (Scopus)

• The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

  Neubert, K., Meister, S., Moser, K., Weisel, F., Maseda, D., Amann, K., Wiethe, C., Winkler, T. H., Kalden, J. R., Manz, R. A. & Voll, R. E., 07.2008, In: Nature Medicine. 14, 7, p. 748-755 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Nephritis 100%
  • Drug-Induced Lupus Erythematosus 100%
  • Proteasome 100%
  • Nephritic Syndrome 100%
  442 Citations (Scopus)
• 2007

  BMP7 promotes adipogenic but not osteo-/chondrogenic differentiation of adult human bone marrow-derived stem cells in high-density micro-mass culture

  Neumann, K., Endres, M., Ringe, J., Flath, B., Manz, R., Häupl, T., Sittinger, M. & Kaps, C., 15.10.2007, In: Journal of Cellular Biochemistry. 102, 3, p. 626-637 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Bone Morphogenetic Protein 7 100%
  • Stem Cell 100%
  • Cancer Growth Factor 42%
  • Gene Expression Profiling 28%
  • Proteoglycan 28%
  46 Citations (Scopus)

• Bortezomib inhibits human osteoclastogenesis

  von Metzler, I., Krebbel, H., Hecht, M., Manz, R. A., Fleissner, C., Mieth, M., Kaiser, M., Jakob, C., Sterz, J., Kleeberg, L., Heider, U. & Sezer, O., 09.2007, In: Leukemia. 21, 9, p. 2025-2034 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • RANKL 100%
  • Osteoclastogenesis 100%
  • Osteoclast Differentiation Factor 100%
  • Immunoglobulin Enhancer Binding Protein 75%
  • Proteasome 50%
  159 Citations (Scopus)

• FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis

  Xiang, Z., Cutler, A. J., Brownlie, R. J., Fairfax, K., Lawlor, K. E., Severinson, E., Walker, E. U., Manz, R. A., Tarlinton, D. M. & Smith, K. G. C., 04.2007, In: Nature Immunology. 8, 4, p. 419-29 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Programmed Cell Death 100%
  • Cross Linking 33%
  • Fc Receptor 16%
  • Systemic Lupus Erythematosus 16%

• VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF

  Schaumann, D. H. S., Tuischer, J., Ebell, W., Manz, R. A. & Lauster, R., 01.01.2007, In: Molecular Immunology. 44, 7, p. 1606-1612 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Stromal Cell 100%
  • Vascular Cell Adhesion Molecule 1 100%
  • Stromal Cell Derived Factor 1 100%
  • Cytokine 100%
  • B-Cell Activating Factor 100%
  34 Citations (Scopus)
• 2006

  Induction of pathogenic anti-dsDNA antibodies is controlled on the level of B cells in a non-lupus prone mouse strain

  Langnickel, D., Enghard, P., Klein, C., Undeutsch, R., Hocher, B., Manz, R., Burmester, G. R. & Riemekasten, G., 01.2006, In: Journal of Clinical Immunology. 26, 1, p. 86-95 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Peptides 100%
  • Immunoglobulin Producing Cell 100%
  • Lupus Erythematosus 100%
  • T Cell 100%
  • Mouse Strain 100%
  4 Citations (Scopus)

• Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c^high dendritic cells

  Hebel, K., Griewank, K., Inamine, A., Chang, H. D., Müller-Hilke, B., Fillatreau, S., Manz, R. A., Radbruch, A. & Jung, S., 11.2006, In: European Journal of Immunology. 36, 11, p. 2912-2919 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Cell Differentiation 100%
  • Dendritic Cell 100%
  • CD11c 33%
  • T Cell 33%
  42 Citations (Scopus)
• 2005

  Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response

  Odendahl, M., Mei, H., Hoyer, B. F., Jacobi, A. M., Hansen, A., Muehlinghaus, G., Berek, C., Hiepe, F., Manz, R., Radbruch, A. & Dörner, T., 15.02.2005, In: Blood. 105, 4, p. 1614-1621 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Antigen Specificity 100%
  • Blood Plasma 100%
  • Secondary Immune Response 100%
  • Lymphoid Organ 40%
  311 Citations (Scopus)

• Long-lived plasma cells and their contribution to autoimmunity

  Hoyer, B. F., Manz, R. A., Radbruch, A. & Hiepe, F., 2005, In: Annals of the New York Academy of Sciences. 1050, p. 124-133 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • Autoimmunity 100%
  • Autoantibody 75%
  • Autoimmune Disease 50%
  • Plasmablast 50%
  79 Citations (Scopus)

• Nongenotoxic activation of the p53 pathway as a therapeutic strategy for multiple myeloma

  Stühmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R. A., Daniel, P. T., Bommert, K., Vassilev, L. T. & Bargou, R. C., 15.11.2005, In: Blood. 106, 10, p. 3609-3617 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein P53 100%
  • Multiple Myeloma 100%
  • Protein MDM2 37%
  • Tumor Cell 25%
  • Nutlin 3 25%
  151 Citations (Scopus)

• Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells

  Muehlinghaus, G., Cigliano, L., Huehn, S., Peddinghaus, A., Leyendeckers, H., Hauser, A. E., Hiepe, F., Radbruch, A., Arce, S. & Manz, R. A., 15.05.2005, In: Blood. 105, 10, p. 3965-3971 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Immunoglobulin Producing Cell 100%
  • CXCR4 100%
  • Chemokine Receptor 100%
  • Memory B Cell 100%
  • Interferon 40%
  153 Citations (Scopus)
• 2004

  CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations

  Arce, S., Luger, E., Muehlinghaus, G., Cassese, G., Hauser, A., Horst, A., Lehnert, K., Odendahl, M., Hönemann, D., Heller, K. D., Kleinschmidt, H., Berek, C., Dörner, T., Krenn, V., Hiepe, F., Bargou, R., Radbruch, A. & Manz, R. A., 06.2004, In: Journal of Leukocyte Biology. 75, 6, p. 1022-1028 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cell Population 100%
  • Immunoglobulin Producing Cell 100%
  • CD38 100%
  • Immunoglobulin G 100%
  • Precursor 100%
  60 Citations (Scopus)

• Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

  Jundt, F., Pröbsting, K. S., Anagnostopoulos, I., Muehlinghaus, G., Chatterjee, M., Mathas, S., Bargou, R. C., Manz, R., Stein, H. & Dörken, B., 01.05.2004, In: Blood. 103, 9, p. 3511-3515 5 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Multiple Myeloma 100%
  • Notch Signaling 100%
  • Notch 100%
  • Myeloma Cell 100%
  • Protein Jagged 1 100%
  179 Citations (Scopus)