Rolf Hilgenfeld

Research output

Research Output per year 1980 2001 2002 2003 2006 2008 2010 2011 2014 2015 2017 2022

• 151 Journal articles
• 22 Scientific review articles
• 12 Chapter
• 11 Comments/Debates
• 10 More
  • 3 Conference contribution
  • 2 Editorial
  • 2 Short survey
  • 1 Anthologies
  • 1 Books
  • 1 Letters

Research Output per year

Research Output per year

Search results

• 2022

  Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

  Dai, W., Jochmans, D., Xie, H., Yang, H., Li, J., Su, H., Chang, D., Wang, J., Peng, J., Zhu, L., Nian, Y., Hilgenfeld, R., Jiang, H., Chen, K., Zhang, L., Xu, Y., Neyts, J. & Liu, H., 24.02.2022, In: Journal of Medicinal Chemistry. 65, 4, p. 2794-2808 15 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Peptidomimetics 100%
  • Severe Acute Respiratory Syndrome 88%
  • Coronavirus 86%
  • Aldehydes 82%
  • Enterovirus 78%
• 2021

  Structural biology in the fight against COVID-19

  Bárcena, M., Barnes, C. O., Beck, M., Bjorkman, P. J., Canard, B., Gao, G. F., Gao, Y., Hilgenfeld, R., Hummer, G., Patwardhan, A., Santoni, G., Saphire, E. O., Schaffitzel, C., Schendel, S. L., Smith, J. L., Thorn, A., Veesler, D., Zhang, P. & Zhou, Q., 01.01.2021, In: Nature structural & molecular biology. 28, 1, p. 2-7 6 p.

  Research output: Journal Articles › Comments/Debates

  • SARS Virus 100%
  • Manuscripts 39%
  • Pandemics 36%
  • Appointments and Schedules 27%
  • Virus Diseases 24%

• The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

  Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., & 26 othersSauve, F., Coêlho, C. F. F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H. C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V. & Schwaninger, M., 11.2021, In: Nature Neuroscience. 24, 11, p. 1522-1533 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Receptor-Interacting Protein Serine-Threonine Kinases 65%
  • Peptide Hydrolases 64%
  • Endothelial Cells 57%

• The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation

  Lei, J., Ma-Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., Thiel, V., Beckmann, R., Deng, W., Leonhardt, H., Hilgenfeld, R. & von Brunn, A., 01.06.2021, In: The EMBO journal. 40, 11, p. e102277

  Research output: Journal Articles › Journal articles › Research › peer-review

  • human PAIP1 protein 100%
  • Severe Acute Respiratory Syndrome 50%
  • Viral RNA 42%
  • Coronavirus 8%
  • Proteins 7%

• X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

  Günther, S., Reinke, P. Y. A., Fernández-García, Y., Lieske, J., Lane, T. J., Ginn, H. M., Koua, F. H. M., Ehrt, C., Ewert, W., Oberthuer, D., Yefanov, O., Meier, S., Lorenzen, K., Krichel, B., Kopicki, J-D., Gelisio, L., Brehm, W., Dunkel, I., Seychell, B., Gieseler, H., & 82 othersNorton-Baker, B., Escudero-Pérez, B., Domaracky, M., Saouane, S., Tolstikova, A., White, T. A., Hänle, A., Groessler, M., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Peck, A., Barthelmess, M., Schlünzen, F., Lourdu Xavier, P., Werner, N., Andaleeb, H., Ullah, N., Falke, S., Srinivasan, V., França, B. A., Schwinzer, M., Brognaro, H., Rogers, C., Melo, D., Zaitseva-Doyle, J. J., Knoska, J., Peña-Murillo, G. E., Mashhour, A. R., Hennicke, V., Fischer, P., Hakanpää, J., Meyer, J., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Beccari, A. R., Bourenkov, G., von Stetten, D., Pompidor, G., Bento, I., Panneerselvam, S., Karpics, I., Schneider, T. R., Garcia-Alai, M. M., Niebling, S., Günther, C., Schmidt, C., Schubert, R., Han, H., Boger, J., Monteiro, D. C. F., Zhang, L., Sun, X., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C. G., Weiss, M. S., Schulz, E-C., Mehrabi, P., Karničar, K., Usenik, A., Loboda, J., Tidow, H., Chari, A., Hilgenfeld, R., Uetrecht, C., Cox, R., Zaliani, A., Beck, T., Rarey, M., Günther, S., Turk, D., Hinrichs, W., Chapman, H. N., Pearson, A. R., Betzel, C. & Meents, A., 07.05.2021, In: Science. 372, 6542, p. 642-646 5 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS coronavirus 3C-like protease 100%
  • Catalytic Domain 44%
  • X-Rays 37%
  • SARS Virus 36%
  • Pharmaceutical Preparations 20%
• 2020

  Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors

  Zhang, L., Lin, D., Sun, X., Curth, U., Drosten, C., Sauerhering, L., Becker, S., Rox, K. & Hilgenfeld, R., 24.04.2020, In: Science. 368, 6489, p. 409-412 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Coronavirus 100%
  • Peptide Hydrolases 66%
  • Pyridones 66%
  • Polyproteins 53%
  • Tropism 47%
  515 Citations (Scopus)

• Processing of the SARS-CoV pp1a/ab nsp7-10 region

  Krichel, B., Falke, S., Hilgenfeld, R., Redecke, L. & Uetrecht, C., 13.03.2020, In: Biochemical Journal. 477, 5, p. 1009-1019 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS Virus 100%
  • Polyproteins 91%
  • Coronavirus 56%
  • Severe Acute Respiratory Syndrome 29%
  • Mass Spectrometry 20%
  21 Citations (Scopus)

• Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses

  Rut, W., Groborz, K., Zhang, L., Modrzycka, S., Poreba, M., Hilgenfeld, R. & Drag, M., 03.2020, In: Antiviral Research. 175, 104731.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • West Nile virus 100%
  • Dengue 87%
  • Peptide Hydrolases 64%
  • Substrate Specificity 28%
  • Polyproteins 17%
  3 Citations (Scopus)

• SARS-CoV-2 M^pro inhibitors and activity-based probes for patient-sample imaging

  Rut, W., Groborz, K., Zhang, L., Sun, X., Zmudzinski, M., Pawlik, B., Wang, X., Jochmans, D., Neyts, J., Młynarski, W., Hilgenfeld, R. & Drag, M., 22.10.2020, In: Nature Chemical Biology.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS Virus 100%
  • SARS coronavirus 3C-like protease 55%
  • Antiviral Agents 34%
  • Coronavirus 17%
  • Fluorescent Dyes 14%

• α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

  Zhang, L., Lin, D., Kusov, Y., Nian, Y., Ma, Q., Wang, J., Von Brunn, A., Leyssen, P., Lanko, K., Neyts, J., De Wilde, A., Snijder, E. J., Liu, H. & Hilgenfeld, R., 14.05.2020, In: Journal of Medicinal Chemistry. 63, 9, p. 4562-4578 17 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Alphacoronavirus 100%
  • Coronavirus 98%
  • Betacoronavirus 91%
  • Enterovirus 90%
  • 3C proteases 84%
  96 Citations (Scopus)
• 2019

  Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018

  Badolo, A., Burt, F., Daniel, S., Fearns, R., Gudo, E. S., Kielian, M., Lescar, J., Shi, Y., von Brunn, A., Weiss, S. R. & Hilgenfeld, R., 02.2019, In: Antiviral Research. 162, p. 142-150 9 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Mozambique 100%
  • Flavivirus 89%
  • Viruses 69%
  • Lassa virus 55%
  • Crimean-Congo hemorrhagic fever virus 55%
  1 Citation (Scopus)
• 2018

  Dengue and Zika: Control and Antiviral Treatment Strategies

  Hilgenfeld, R. & Vasudevan, S. G., 30.05.2018, 1 ed. Springer Verlag. 375 p. (Advances in Experimental Medicine and Biology)

  Research output: Books/Anthologies/Proceedings/Theses › Anthologies › peer-review

  • Dengue 100%
  • Zika Virus 77%
  • Antiviral Agents 75%
  • Dengue Virus 69%
  • Mosquito Control 44%

• Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

  Lei, J., Kusov, Y. & Hilgenfeld, R., 01.01.2018, In: Antiviral Research. 149, p. 58-74 17 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Coronavirus 100%
  • Protein Domains 80%
  • Proteins 29%
  • Ubiquitin 22%
  • Middle East Respiratory Syndrome Coronavirus 17%

• Preface

  Hilgenfeld, R. & Vasudevan, S. G., 2018, In: Advances in experimental medicine and biology. 1062, p. v-vi

  Research output: Journal Articles › Editorial

• The Structure of the Zika Virus Protease, NS2B/NS3^pro

  Hilgenfeld, R., Lei, J. & Zhang, L., 30.05.2018, Advances in Experimental Medicine and Biology. Singapore: Springer Singapore, Vol. 1062. p. 131-145 15 p. (Advances in Experimental Medicine and Biology; vol. 1062).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • Zika Virus 100%
  • Peptide Hydrolases 63%
  • Boronic Acids 20%
  • X Ray Crystallography 17%
  • Peptides 16%

• Viral entry and NS1 as potential antiviral drug targets

  de Silva, A. M., Rey, F. A., Young, P. R., Hilgenfeld, R. & Vasudevan, S. G., 01.01.2018, Advances in Experimental Medicine and Biology. Singapore: Springer Singapore, Vol. 1062. p. 107-113 7 p. (Advances in Experimental Medicine and Biology; vol. 1062).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • Cryoelectron Microscopy 100%
  • Zika Virus 97%
  • Dengue Virus 87%
  • Antiviral Agents 63%
  • Virus Diseases 54%
• 2017

  Computer-aided structure based drug design approaches for the discovery of new anti-CHIKV agents

  Jadav, S. S., Sinha, B. N., Hilgenfeld, R. & Jayaprakash, V., 01.12.2017, In: Current Computer-Aided Drug Design. 13, 4, p. 346-361 16 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Chikungunya virus 100%
  • Drug Design 82%
  • Chikungunya Fever 35%
  • Aedes 29%
  • Drug Development 22%

• Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus

  Wang, H., Han, M., Qi, J., Hilgenfeld, R., Luo, T., Shi, Y., Gao, G. F. & Song, H., 01.12.2017, In: Science China Life Sciences. 60, 12, p. 1403-1406 4 p.

  Research output: Journal Articles › Letters › peer-review

  1 Citation (Scopus)

• Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

  Kouretova, J., Hammamy, M. Z., Epp, A., Hardes, K., Kallis, S., Zhang, L., Hilgenfeld, R., Bartenschlager, R. & Steinmetzer, T., 01.01.2017, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 32, 1, p. 712-721 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Furin 100%
  • West Nile virus 91%
  • Dengue Virus 83%
  • Virus Replication 70%
  • Peptide Hydrolases 58%
  4 Citations (Scopus)

• Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

  Rut, W., Zhang, L., Kasperkiewicz, P., Poreba, M., Hilgenfeld, R. & Drąg, M., 01.03.2017, Antiviral Research. Elsevier B.V., p. 88-94 7 p. (Antiviral Research; vol. 139).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • Zika Virus 100%
  • Substrate Specificity 84%
  • Peptide Hydrolases 63%
  • Amino Acids 53%
  • Organophosphonates 37%

• Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold

  Tan, W. L., Wong, K. H., Lei, J., Sakai, N., Tan, H. W., Hilgenfeld, R. & Tam, J. P., 01.12.2017, In: Scientific Reports. 7, 1, 5194.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lycium 100%
  • Cystine 79%
  • Cysteine 57%
  • Peptides 39%
  • Disulfides 24%

• Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

  Nitsche, C., Zhang, L., Weigel, L. F., Schilz, J., Graf, D., Bartenschlager, R., Hilgenfeld, R. & Klein, C. D., 12.01.2017, In: Journal of Medicinal Chemistry. 60, 1, p. 511-516 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Boronic Acids 100%
  • Pharmaceutical Chemistry 82%
  • West Nile virus 78%
  • Protease Inhibitors 62%
  • Peptide Hydrolases 50%
  10 Citations (Scopus)

• RNA-virus proteases counteracting host innate immunity

  Lei, J. & Hilgenfeld, R., 01.10.2017, In: FEBS Letters. 591, 20, p. 3190-3210 21 p.

  Research output: Journal Articles › Scientific review articles › Research

  • RNA Viruses 100%
  • Innate Immunity 81%
  • Peptide Hydrolases 73%
  • Viruses 58%
  • Coronaviridae 51%
  3 Citations (Scopus)

• STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease

  Schöne, T., Grimm, L. L., Sakai, N., Zhang, L., Hilgenfeld, R. & Peters, T., 2017, In: Antiviral Research. 146, p. 174-183 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • West Nile virus 100%
  • Peptide Hydrolases 64%
  • 2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine 39%
  • Binding Sites 39%
  • Flaviviridae 37%
• 2016

  Coxsackievirus B3 protease 3C: Expression, purification, crystallization and preliminary structural insights

  Fili, S., Valmas, A., Christopoulou, M., Spiliopoulou, M., Nikolopoulos, N., Lichière, J., Logotheti, S., Karavassili, F., Rosmaraki, E., Fitch, A., Wright, J., Beckers, D., Degen, T., Nénert, G., Hilgenfeld, R., Papageorgiou, N., Canard, B., Coutard, B. & Margiolaki, I., 01.12.2016, In: Acta Crystallographica Section:F Structural Biology Communications. 72, 12, p. 877-884 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • 3C proteases 100%
  • Powder Diffraction 76%
  • Crystallization 75%
  • X-Ray Diffraction 74%
  • Peptide Hydrolases 31%

• Crystal structure of zika virus ns2b-ns3 protease in complex with a boronate inhibitor

  Lei, J., Hansen, G., Nitsche, C., Klein, C. D., Zhang, L. & Hilgenfeld, R., 29.07.2016, In: Science. 353, 6298, p. 503-505 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Zika Virus 100%
  • Peptide Hydrolases 63%
  • Boronic Acids 62%
  • Polyproteins 51%
  • 4-aminomethylphenylalanine 48%
  59 Citations (Scopus)

• Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

  Becker, D., Kaczmarska, Z., Arkona, C., Schulz, R., Tauber, C., Wolber, G., Hilgenfeld, R., Coll, M. & Rademann, J., 28.09.2016, In: Nature Communications. 7, 12761.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • 3C proteases 100%
  • Enterovirus 71%
  • Enzyme Inhibitors 71%
  • Protein Binding 61%
  • X Ray Crystallography 42%
  6 Citations (Scopus)

• p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PL ^pro via E3 ubiquitin ligase RCHY1

  Ma-Lauer, Y., Carbajo-Lozoya, J., Hein, M. Y., Müller, M. A., Deng, W., Lei, J., Meyer, B., Kusov, Y., von Brunn, B., Bairad, D. R., Hünten, S., Drosten, C., Hermeking, H., Leonhardt, H., Mann, M., Hilgenfeld, R. & von Brunn, A., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. p. 5192-5201

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS Virus 100%
  • Coronavirus 85%
  • Ubiquitin-Protein Ligases 77%
  • Severe Acute Respiratory Syndrome 72%
  • Down-Regulation 47%

• Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

  Lei, J. & Hilgenfeld, R., 01.08.2016, In: Virologica Sinica. 31, 4, p. 288-299 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Middle East Respiratory Syndrome Coronavirus 100%
  • Papain 87%
  • Ubiquitin 66%
  • Peptide Hydrolases 55%
  • SARS Virus 12%
  8 Citations (Scopus)

• Zika virus NS1, a pathogenicity factor with many faces

  Hilgenfeld, R., 15.12.2016, In: The EMBO journal. 35, 24, p. 2631-2633 3 p.

  Research output: Journal Articles › Comments/Debates

  2 Citations (Scopus)
• 2015

  Acquisition of new protein domains by coronaviruses: analysis of overlapping genes coding for proteins N and 9b in SARS coronavirus

  Shukla, A. & Hilgenfeld, R., 01.01.2015, In: Virus Genes. 50, 1, p. 29-38 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS Virus 100%
  • Overlapping Genes 99%
  • Coronavirus 85%
  • Protein Domains 68%
  • Reading Frames 44%
  4 Citations (Scopus)

• A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex

  Kusov, Y., Tan, J., Alvarez, E., Enjuanes, L. & Hilgenfeld, R., 04.07.2015, In: Virology. 484, p. 313-322 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • SARS Virus 100%
  • G-Quadruplexes 99%
  • Poly-ADP-Ribose Binding Proteins 49%
  • oligo(G) 48%
  • Renilla Luciferases 35%
  8 Citations (Scopus)

• Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68

  Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., Van Kuppeveld, F. J. M., Leyssen, P., Hilgenfeld, R., Neyts, J. & Delang, L., 01.12.2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7782-7785 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • pleconaril 100%
  • Human Enterovirus D 87%
  • 3C proteases 86%
  • Enterovirus 61%
  • pirodavir 57%
  16 Citations (Scopus)

• Crystal structure of the peroxo-diiron(III) intermediate of deoxyhypusine hydroxylase, an oxygenase involved in hypusination

  Han, Z., Sakai, N., Böttger, L. H., Klinke, S., Hauber, J., Trautwein, A. X. & Hilgenfeld, R., 05.05.2015, Structure. Cell Press, p. 882-892 11 p. (Structure; vol. 23).

  Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

  • deoxyhypusine hydroxylase 100%
  • eukaryotic translation initiation factor 5A 89%
  • Oxygenases 70%
  • deoxyhypusine 33%
  • hypusine 29%

• Identification of pyrazole derivative as an antiviral agent against chikungunya through HTVS

  Jadav, S. S., Sinha, B. N., Pastorino, B., De Lamballerie, X., Hilgenfeld, R. & Jayaprakash, V., 2015, In: Letters in Drug Design and Discovery. 12, 4, p. 292-301 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Cytopathic 100%
  • Antiviral Agent 82%
  • Protease Inhibitor 75%
  • Pyrazole 66%
  • Schiff Base 53%
  14 Citations (Scopus)

• Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis

  Kohlmann, F., Shima, K., Rupp, J., Solbach, W., Hilgenfeld, R. & Hansen, G., 01.01.2015, In: Acta Crystallographica Section:F Structural Biology Communications. 71, p. 1454-1458 5 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Crystallization 100%
  • X-Ray Diffraction 98%
  • Chlamydia trachomatis 95%
  • Peptide Hydrolases 69%
  • Chlamydia 49%

• Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441

  Kohlmann, F., Shima, K., Hilgenfeld, R., Solbach, W., Rupp, J. & Hansen, G., 01.01.2015, In: Journal of Bacteriology. 197, 1, p. 211-218 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Chlamydia trachomatis 100%
  • Female Infertility 60%
  • Post-Synaptic Density 58%
  • Chlamydia 51%
  • Tight Junctions 49%
  3 Citations (Scopus)

• Structures of DegQ from Legionella pneumophila Define Distinct on and off States

  Schubert, A., Wrase, R., Hilgenfeld, R. & Hansen, G., 17.08.2015, In: Journal of Molecular Biology. 427, 17, p. 2840-2851 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Legionella pneumophila 100%
  • Bacterial Physiological Phenomena 37%
  • Temperature 36%
  • Chymases 36%
  • Post-Synaptic Density 34%
  4 Citations (Scopus)

• The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir

  Lacroix, C., George, S., Leyssen, P., Hilgenfeld, R. & Neyts, J., 01.09.2015, In: Antimicrobial Agents and Chemotherapy. 59, 9, p. 5814-5818 5 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • rupintrivir 100%
  • 3C proteases 80%
  • Rhinovirus 65%
  • Enterovirus 57%
  • Protease Inhibitors 51%
  6 Citations (Scopus)
• 2014

  Accessory proteins of SARS-CoV and other coronaviruses

  Liu, D. X., Fung, T. S., Chong, K. K. L., Shukla, A. & Hilgenfeld, R., 01.01.2014, In: Antiviral Research. 109, 1, p. 97-109 13 p.

  Research output: Journal Articles › Scientific review articles › Research

  • SARS Virus 100%
  • Coronavirus 85%
  • Proteins 24%
  • X Ray Crystallography 18%
  • Host Microbial Interactions 16%
  25 Citations (Scopus)

• Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

  Van Der Linden, L., Ulferts, R., Nabuurs, S. B., Kusov, Y., Liu, H., George, S., Lacroix, C., Goris, N., Lefebvre, D., Lanke, K. H. W., De Clercq, K., Hilgenfeld, R., Neyts, J. & Van Kuppeveld, F. J. M., 01.03.2014, In: Antiviral Research. 103, 1, p. 17-24 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • 3C proteases 100%
  • Picornaviridae 85%
  • Peptide Hydrolases 52%
  • rupintrivir 46%
  • Firefly Luciferases 21%
  3 Citations (Scopus)

• Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

  Lei, J., Mesters, J. R., Drosten, C., Anemüller, S., Ma, Q. & Hilgenfeld, R., 01.01.2014, In: Antiviral Research. 109, 1, p. 72-82 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Middle East Respiratory Syndrome Coronavirus 100%
  • Papain 87%
  • Coronavirus 83%
  • Catalytic Domain 60%
  • Peptide Hydrolases 55%
  31 Citations (Scopus)

• From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

  Hilgenfeld, R., 01.09.2014, In: The FEBS journal. 281, 18, p. 4085-4096 12 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Coronavirus 100%
  • Drug Design 91%
  • Antiviral Agents 68%
  • Peptide Hydrolases 66%
  • SARS Virus 58%
  25 Citations (Scopus)

• The capsid binder vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

  Tijsma, A., Franco, D., Tucker, S., Hilgenfeld, R., Froeyen, M., Leyssen, P. & Neyts, J., 01.11.2014, In: Antimicrobial Agents and Chemotherapy. 58, 11, p. 6990-6992 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Capsid 100%
  • Enterovirus 99%
  • pirodavir 92%
  • Protease Inhibitors 89%
  • pleconaril 80%
  19 Citations (Scopus)

• The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon

  Rocha-Pereira, J., Nascimento, M. S. J., Ma, Q., Hilgenfeld, R., Neyts, J. & Jochmansb, D., 01.01.2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4675-4681 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • rupintrivir 100%
  • Norovirus 64%
  • Replicon 63%
  • Enterovirus 57%
  • Protease Inhibitors 51%
  14 Citations (Scopus)

• The evolution of insulin glargine and its continuing contribution to diabetes care

  Hilgenfeld, R., Seipke, G., Berchtold, H. & Owens, D. R., 01.01.2014, In: Drugs. 74, 8, p. 911-927 17 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Insulin Glargine 100%
  • Insulin 48%
  • Meals 14%
  • Long-Acting Insulin 11%
  • Insulins 11%
  18 Citations (Scopus)

• Thiazolidone derivatives as inhibitors of chikungunya virus

  Jadav, S. S., Sinha, B. N., Hilgenfeld, R., Pastorino, B., De Lamballerie, X. & Jayaprakash, V., 01.01.2014, In: European Journal of Medicinal Chemistry. 89, p. 172-178 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Chikungunya virus 100%
  • Peptide Hydrolases 59%
  • Molecular Docking Simulation 34%
  • Vero Cells 29%
  • Antiviral Agents 20%
  18 Citations (Scopus)
• 2013

  3C protease of enterovirus 68: Structure-based design of michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses

  Tan, J., George, S., Kusov, Y., Perbandt, M., Anemüller, S., Mesters, J. R., Norder, H., Coutard, B., Lacroix, C., Leyssen, P., Neyts, J. & Hilgenfeld, R., 01.04.2013, In: Journal of Virology. 87, 8, p. 4339-4351 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Human Enterovirus D 100%
  • 3C proteases 98%
  • Picornaviridae 84%
  • Rhinovirus 79%
  • Poliovirus 57%
  34 Citations (Scopus)

• Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response

  Hansen, G. & Hilgenfeld, R., 01.03.2013, In: Cellular and Molecular Life Sciences. 70, 5, p. 761-775 15 p.

  Research output: Journal Articles › Scientific review articles › Research

  • Quality Control 100%
  • Temperature 73%
  • Peptide Hydrolases 51%
  • Proteins 37%
  • PDZ Domains 28%
  44 Citations (Scopus)

• Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B-NS3 Protease

  Hammamy, M. Z., Haase, C., Hammami, M., Hilgenfeld, R. & Steinmetzer, T., 01.02.2013, In: ChemMedChem. 8, 2, p. 231-241 11 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Peptidomimetics 100%
  • West Nile virus 89%
  • lysyllysine 61%
  • matriptase 57%
  • trypsin-like serine protease 57%
  28 Citations (Scopus)