Hilgenfeld Rolf

Prof. Dr. rer. nat. Dr. h.c.

  • Ratzeburger Allee 160, BMF (Geb. 67), 4. OG, Raum 4

    23562 Lübeck

    Germany

  • 17669
    Citations
1980 …2022

Research activity per year

Personal profile

Equipment

HPLC/ESI-Ionenfallen-Massenspektrometer

Scientific Focus

Crystallography

Molecular Biology

Proteomics

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

    Dai, W., Jochmans, D., Xie, H., Yang, H., Li, J., Su, H., Chang, D., Wang, J., Peng, J., Zhu, L., Nian, Y., Hilgenfeld, R., Jiang, H., Chen, K., Zhang, L., Xu, Y., Neyts, J. & Liu, H., 24.02.2022, In: Journal of Medicinal Chemistry. 65, 4, p. 2794-2808 15 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Structural biology in the fight against COVID-19

    Bárcena, M., Barnes, C. O., Beck, M., Bjorkman, P. J., Canard, B., Gao, G. F., Gao, Y., Hilgenfeld, R., Hummer, G., Patwardhan, A., Santoni, G., Saphire, E. O., Schaffitzel, C., Schendel, S. L., Smith, J. L., Thorn, A., Veesler, D., Zhang, P. & Zhou, Q., 01.01.2021, In: Nature structural & molecular biology. 28, 1, p. 2-7 6 p.

    Research output: Journal ArticlesComments/Debates

  • The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

    Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., & 26 othersSauve, F., Coêlho, C. F. F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H. C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V. & Schwaninger, M., 11.2021, In: Nature Neuroscience. 24, 11, p. 1522-1533 12 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation

    Lei, J., Ma-Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., Thiel, V., Beckmann, R., Deng, W., Leonhardt, H., Hilgenfeld, R. & von Brunn, A., 01.06.2021, In: The EMBO journal. 40, 11, p. e102277

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

    Günther, S., Reinke, P. Y. A., Fernández-García, Y., Lieske, J., Lane, T. J., Ginn, H. M., Koua, F. H. M., Ehrt, C., Ewert, W., Oberthuer, D., Yefanov, O., Meier, S., Lorenzen, K., Krichel, B., Kopicki, J-D., Gelisio, L., Brehm, W., Dunkel, I., Seychell, B., Gieseler, H., & 82 othersNorton-Baker, B., Escudero-Pérez, B., Domaracky, M., Saouane, S., Tolstikova, A., White, T. A., Hänle, A., Groessler, M., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Peck, A., Barthelmess, M., Schlünzen, F., Lourdu Xavier, P., Werner, N., Andaleeb, H., Ullah, N., Falke, S., Srinivasan, V., França, B. A., Schwinzer, M., Brognaro, H., Rogers, C., Melo, D., Zaitseva-Doyle, J. J., Knoska, J., Peña-Murillo, G. E., Mashhour, A. R., Hennicke, V., Fischer, P., Hakanpää, J., Meyer, J., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Beccari, A. R., Bourenkov, G., von Stetten, D., Pompidor, G., Bento, I., Panneerselvam, S., Karpics, I., Schneider, T. R., Garcia-Alai, M. M., Niebling, S., Günther, C., Schmidt, C., Schubert, R., Han, H., Boger, J., Monteiro, D. C. F., Zhang, L., Sun, X., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C. G., Weiss, M. S., Schulz, E-C., Mehrabi, P., Karničar, K., Usenik, A., Loboda, J., Tidow, H., Chari, A., Hilgenfeld, R., Uetrecht, C., Cox, R., Zaliani, A., Beck, T., Rarey, M., Günther, S., Turk, D., Hinrichs, W., Chapman, H. N., Pearson, A. R., Betzel, C. & Meents, A., 07.05.2021, In: Science. 372, 6542, p. 642-646 5 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review