Rolf Hilgenfeld

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Hilgenfeld Rolf

Prof. Dr. rer. nat. Dr. h.c.

 https://orcid.org/0000-0001-8850-2977

  • Ratzeburger Allee 160, Gebäude 62, 1. OG, Raum 106

    23562 Lübeck

    Germany

  • 16942
    Citations
1980 …2022

Research activity per year

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Personal profile

Equipment

HPLC/ESI-Ionenfallen-Massenspektrometer

Scientific Focus

Crystallography

Molecular Biology

Proteomics

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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Collaborations and top research areas from the last five years

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  • Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

    Dai, W., Jochmans, D., Xie, H., Yang, H., Li, J., Su, H., Chang, D., Wang, J., Peng, J., Zhu, L., Nian, Y., Hilgenfeld, R., Jiang, H., Chen, K., Zhang, L., Xu, Y., Neyts, J. & Liu, H., 24.02.2022, In: Journal of Medicinal Chemistry. 65, 4, p. 2794-2808 15 p.

    Research output: Journal Articles › Journal articles › Research › peer-review

  • Structural biology in the fight against COVID-19

    Bárcena, M., Barnes, C. O., Beck, M., Bjorkman, P. J., Canard, B., Gao, G. F., Gao, Y., Hilgenfeld, R., Hummer, G., Patwardhan, A., Santoni, G., Saphire, E. O., Schaffitzel, C., Schendel, S. L., Smith, J. L., Thorn, A., Veesler, D., Zhang, P. & Zhou, Q., 01.01.2021, In: Nature structural & molecular biology. 28, 1, p. 2-7 6 p.

    Research output: Journal Articles › Comments/Debates

  • The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

    Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., & 26 othersSauve, F., Coêlho, C. F. F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H. C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V. & Schwaninger, M., 11.2021, In: Nature Neuroscience. 24, 11, p. 1522-1533 12 p.

    Research output: Journal Articles › Journal articles › Research › peer-review

  • The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation

    Lei, J., Ma-Lauer, Y., Han, Y., Thoms, M., Buschauer, R., Jores, J., Thiel, V., Beckmann, R., Deng, W., Leonhardt, H., Hilgenfeld, R. & von Brunn, A., 01.06.2021, In: The EMBO journal. 40, 11, p. e102277

    Research output: Journal Articles › Journal articles › Research › peer-review

  • X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

    Günther, S., Reinke, P. Y. A., Fernández-García, Y., Lieske, J., Lane, T. J., Ginn, H. M., Koua, F. H. M., Ehrt, C., Ewert, W., Oberthuer, D., Yefanov, O., Meier, S., Lorenzen, K., Krichel, B., Kopicki, J-D., Gelisio, L., Brehm, W., Dunkel, I., Seychell, B., Gieseler, H., & 82 othersNorton-Baker, B., Escudero-Pérez, B., Domaracky, M., Saouane, S., Tolstikova, A., White, T. A., Hänle, A., Groessler, M., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Peck, A., Barthelmess, M., Schlünzen, F., Lourdu Xavier, P., Werner, N., Andaleeb, H., Ullah, N., Falke, S., Srinivasan, V., França, B. A., Schwinzer, M., Brognaro, H., Rogers, C., Melo, D., Zaitseva-Doyle, J. J., Knoska, J., Peña-Murillo, G. E., Mashhour, A. R., Hennicke, V., Fischer, P., Hakanpää, J., Meyer, J., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Beccari, A. R., Bourenkov, G., von Stetten, D., Pompidor, G., Bento, I., Panneerselvam, S., Karpics, I., Schneider, T. R., Garcia-Alai, M. M., Niebling, S., Günther, C., Schmidt, C., Schubert, R., Han, H., Boger, J., Monteiro, D. C. F., Zhang, L., Sun, X., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C. G., Weiss, M. S., Schulz, E-C., Mehrabi, P., Karničar, K., Usenik, A., Loboda, J., Tidow, H., Chari, A., Hilgenfeld, R., Uetrecht, C., Cox, R., Zaliani, A., Beck, T., Rarey, M., Günther, S., Turk, D., Hinrichs, W., Chapman, H. N., Pearson, A. R., Betzel, C. & Meents, A., 07.05.2021, In: Science. 372, 6542, p. 642-646 5 p.

    Research output: Journal Articles › Journal articles › Research › peer-review

View all 207 research outputs
View all 13 projects

  • Thomas Fredenhagen Award 2023

    Hilgenfeld, Rolf (Recipient) & Rahmanzadeh, Ramtin (Recipient), 04.05.2023

    Prize: Awards of the University of Luebeck

  • XtalConcepts

    Rolf Hilgenfeld (Founder), Dierk Hiltershaus (Founder), Annette Eckhardt (Founder), Arne Meyer (Founder) & Kartsten Diercks (Founder)

    Impact