Jens Humrich

Research output

Research Output per year 2003 2006 2015 2016 2018 2019 2020 2022 2023 2023

• 30 Journal articles
• 9 Scientific review articles
• 8 Letters
• 2 Comments/Debates
• 3 More
  • 2 Short survey
  • 1 Chapter

Research Output per year

Research Output per year

Search results

• 2023

  Autoantibodies against the chemokine receptor 3 predict cardiovascular risk

  Müller, F. S., Aherrahrou, Z., Grasshoff, H., Heidorn, M. W., Humrich, J. Y., Johanson, L., Aherrahrou, R., Reinberger, T., Schulz, A., ten Cate, V., Robles, A. P., Koeck, T., Rapp, S., Lange, T., Brachaczek, L., Luebber, F., Erdmann, J., Heidecke, H., Schulze-Forster, K., Dechend, R., & 10 othersLackner, K. J., Pfeiffer, N., Kerahrodi, J. G., Tüscher, O., Schwarting, A., Strauch, K., Münzel, T., Prochaska, J. H., Riemekasten, G. & Wild, P. S., 14.12.2023, In: European Heart Journal. 44, 47, p. 4935-4949 15 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • CXCR3 Receptors 100%
  • Chemokine Receptors 69%
  • Autoantibodies 57%
  • Atherosclerosis 11%
  • Apolipoproteins E 10%
  2 Citations (Scopus)

• Regulatory T cells inhibit autoantigen-specific CD4⁺ T cell responses in lupus-prone NZB/W F1 mice

  Rosenberger, S., Undeutsch, R., Akbarzadeh, R., Ohmes, J., Enghard, P., Riemekasten, G. & Humrich, J. Y., 2023, In: Frontiers in Immunology. 14, 1254176.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoantigens 100%
  • Regulatory T-Lymphocytes 89%
  • T-Lymphocytes 55%
  • Systemic Lupus Erythematosus 18%
  • In Vitro Techniques 17%
• 2022

  Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity

  Cabral-Marques, O., Halpert, G., Schimke, L. F., Ostrinski, Y., Vojdani, A., Baiocchi, G. C., Freire, P. P., Filgueiras, I. S., Zyskind, I., Lattin, M. T., Tran, F., Schreiber, S., Marques, A. H. C., Plaça, D. R., Fonseca, D. L. M., Humrich, J. Y., Müller, A., Giil, L. M., Graßhoff, H., Schumann, A., & 16 othersHackel, A., Junker, J., Meyer, C., Ochs, H. D., Lavi, Y. B., Scheibenbogen, C., Dechend, R., Jurisica, I., Schulze-Forster, K., Silverberg, J. I., Amital, H., Zimmerman, J., Heidecke, H., Rosenberg, A. Z., Riemekasten, G. & Shoenfeld, Y., 12.2022, In: Nature Communications. 13, 1, 1220.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoantibodies 100%
  • G-Protein-Coupled Receptors 54%
  • Antibodies 30%
  • Machine Learning 20%
  • Chemokine Receptors 20%
  31 Citations (Scopus)

• Der außergewöhnliche Nachahmer einer Polymyositis

  Translated title of the contribution: The unusual mimicker of a polymyositisJendrek, S. T., Glatzel, M., Pauli, D., Schinke, S., Humrich, J. Y., Lamprecht, P. & Riemekasten, G., 10.2022, In: Zeitschrift fur Rheumatologie. 81, 8, p. 682-685 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Hantavirus 100%
  • Polymyositis 94%
  • Myositis 85%
  • Cyclosporine 33%
  • Cyclophosphamide 32%

• Low-dose interleukin-2 therapy in active systemic lupus erythematosus (LUPIL-2): a multicentre, double-blind, randomised and placebo-controlled phase II trial

  Humrich, J. Y., Cacoub, P., Rosenzwajg, M., Pitoiset, F., Pham, H. P., Guidoux, J., Leroux, D., Vazquez, T., Riemekasten, G., Smolen, J. S., Tsokos, G. & Klatzmann, D., 16.08.2022, In: Annals of the Rheumatic Diseases. 81, 12, p. 1685-1694 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Systemic Lupus Erythematosus 100%
  • Interleukin-2 94%
  • Placebos 73%
  • Bulgaria 29%
  • Population 24%
  14 Citations (Scopus)
• 2020

  Evaluation of choroidal substructure perfusion in patients affected by systemic sclerosis: an optical coherence tomography angiography study

  Ranjbar, M., Rothe, M., Klapa, S., Lange, T., Prasuhn, M., Grisanti, S., Riemekasten, G. & Humrich, J. Y., 03.03.2020, In: Scandinavian Journal of Rheumatology. 49, 2, p. 141-145 5 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Systemic Scleroderma 100%
  • Optical Coherence Tomography 87%
  • Angiography 70%
  • Perfusion 66%
  • Choroid 45%

• Extracorporeal membrane oxygenation in ANCA-associated vasculitis

  Arnold, S., Deja, M., Nitschke, M., Bohnet, S., Wallis, S., Humrich, J. Y., Riemekasten, G., Steinhoff, J. & Lamprecht, P., 11.11.2020, In: Autoimmunity Reviews. 20, 1, p. 102702 102702.

  Research output: Journal Articles › Journal articles › Research › peer-review

• Identification and characterization of antigen-specific CD4⁺ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods

  Tesch, S., Abdirama, D., Grießbach, A. S., Brand, H. A., Goerlich, N., Humrich, J. Y., Bacher, P., Hiepe, F., Riemekasten, G. & Enghard, P., 12.2020, In: Scientific Reports. 10, 1, p. 21312 21312.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • CD4 Antigens 100%
  • Lupus Nephritis 96%
  • Antigens 50%
  • T-Lymphocytes 48%
  • Vimentin 16%

• Nuclear antigen–reactive CD4⁺ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys

  Abdirama, D., Tesch, S., Grießbach, A. S., von Spee-Mayer, C., Humrich, J. Y., Stervbo, U., Babel, N., Meisel, C., Alexander, T., Biesen, R., Bacher, P., Scheffold, A., Eckardt, K. U., Hiepe, F., Radbruch, A., Burmester, G. R., Riemekasten, G. & Enghard, P., 24.06.2020, In: Kidney International.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Systemic Lupus Erythematosus 100%
  • Nuclear Antigens 68%
  • Cytokines 65%
  • T-Lymphocytes 65%
  • Kidney 57%
  2 Citations (Scopus)
• 2019

  IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis

  Rose, A., von Spee-Mayer, C., Kloke, L., Wu, K., Kühl, A., Enghard, P., Burmester, G. R., Riemekasten, G. & Humrich, J. Y., 11.10.2019, In: Cells. 8, 10

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lupus Nephritis 100%
  • Interleukin-2 73%
  • T-Lymphocytes 50%
  • Inflammation 48%
  • Kidney 44%
  1 Citation (Scopus)

• Low-dose interleukin-2 therapy in refractory systemic lupus erythematosus: an investigator-initiated, single-centre phase 1 and 2a clinical trial

  Humrich, J. Y., von Spee-Mayer, C., Siegert, E., Bertolo, M., Rose, A., Abdirama, D., Enghard, P., Stuhlmüller, B., Sawitzki, B., Huscher, D., Hiepe, F., Alexander, T., Feist, E., Radbruch, A., Burmester, G. R. & Riemekasten, G., 09.2019, In: The Lancet Rheumatology. 1, 1, p. e44-e54

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Clinical Trials, Phase I 100%
  • Systemic Lupus Erythematosus 77%
  • Interleukin-2 73%
  • Research Personnel 57%
  • Regulatory T-Lymphocytes 57%
  10 Citations (Scopus)
• 2018

  GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

  Cabral-Marques, O., Marques, A., Giil, L. M., De Vito, R., Rademacher, J., Günther, J., Lange, T., Humrich, J. Y., Klapa, S., Schinke, S., Schimke, L. F., Marschner, G., Pitann, S., Adler, S., Dechend, R., Müller, D. N., Braicu, I., Sehouli, J., Schulze-Forster, K., Trippel, T., & 16 othersScheibenbogen, C., Staff, A., Mertens, P. R., Löbel, M., Mastroianni, J., Plattfaut, C., Gieseler, F., Dragun, D., Engelhardt, B. E., Fernandez-Cabezudo, M. J., Ochs, H. D., al-Ramadi, B. K., Lamprecht, P., Mueller, A., Heidecke, H. & Riemekasten, G., 01.12.2018, In: Nature Communications. 9, 1, 5224.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • G-Protein-Coupled Receptors 100%
  • Autoantibodies 91%
  • Homeostasis 73%
  • Endothelin A Receptors 57%
  • Tissue Donors 33%
  3 Citations (Scopus)
• 2017

  Mapping urinary chemokines in human lupus nephritis: Potentially redundant pathways recruit CD4+ and CD8+ T cells and macrophages

  Klocke, J., Kopetschke, K., Grießbach, A. S., Langhans, V., Humrich, J. Y., Biesen, R., Dragun, D., Radbruch, A., Burmester, G. R., Riemekasten, G. & Enghard, P., 01.01.2017, In: European Journal of Immunology. 47, 1, p. 180-192 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lupus Nephritis 100%
  • Chemokines 77%
  • Macrophages 57%
  • T-Lymphocytes 50%
  • Chemokine Receptors 13%
  10 Citations (Scopus)
• 2016

  IL-2- Therapie beim SLE – Selektive Rekonstitution immunologischer Toleranz

  Translated title of the contribution: IL-2-Therapy in SLE- Selective reconstitution of immunological toleranceHumrich, J. Y. & Riemekasten, G., 01.06.2016, In: Zeitschrift fur Rheumatologie. 75, 5, p. 490-492 3 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  2 Citations (Scopus)

• Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

  von Spee-Mayer, C., Siegert, E., Abdirama, D., Rose, A., Klaus, A., Alexander, T., Enghard, P., Sawitzki, B., Hiepe, F., Radbruch, A., Burmester, G-R., Riemekasten, G. & Humrich, J. Y., 07.2016, In: Annals of the Rheumatic Diseases. 75, 7, p. 1407-15 9 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T-Lymphocytes 100%
  • Systemic Lupus Erythematosus 94%
  • Interleukin-2 89%
  • Blood Cells 27%
  • aldesleukin 20%
• 2015

  Regulatorische T-Zellen und rheumatische Erkrankungen

  Translated title of the contribution: Regulatory T cells and rheumatic diseasesHumrich, J. Y., Kamradt, T. & Riemekasten, G., 02.2015, In: Zeitschrift fur Rheumatologie. 74, 1, p. 26-32 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Rheumatic Diseases 100%
  • Regulatory T-Lymphocytes 93%
  • Autoimmune Diseases 81%
  • Medicine 45%
  • Peripheral Tolerance 43%
  3 Citations (Scopus)

• The cellular signature of urinary immune cells in Lupus nephritis: New insights into potential biomarkers

  Kopetschke, K., Klocke, J., Grießbach, A. S., Humrich, J. Y., Biesen, R., Dragun, D., Burmester, G. R., Enghard, P. & Riemekasten, G., 03.04.2015, In: Arthritis Research and Therapy. 17, 1, 94.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lupus Nephritis 100%
  • Biomarkers 53%
  • T-Lymphocytes 44%
  • Area Under Curve 41%
  • B-Lymphocytes 31%
  31 Citations (Scopus)
• 2014

  Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response

  Enghard, P., Rieder, C., Kopetschke, K., Klocke, J. R., Undeutsch, R., Biesen, R., Dragun, D., Gollasch, M., Schneider, U., Aupperle, K., Humrich, J. Y., Hiepe, F., Backhaus, M., Radbruch, A. H., Burmester, G. R. & Riemekasten, G., 01.2014, In: Annals of the Rheumatic Diseases. 73, 1, p. 277-283 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Lupus Nephritis 100%
  • Systemic Lupus Erythematosus 77%
  • T-Lymphocytes 50%
  • CD4 Lymphocyte Count 16%
  • Therapeutics 13%
  40 Citations (Scopus)
• 2013

  CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice

  Weigert, O., von Spee, C., Undeutsch, R., Kloke, L., Humrich, J. Y. & Riemekasten, G., 27.02.2013, In: Arthritis Research and Therapy. 15, 1, R35.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T-Lymphocytes 100%
  • Systemic Lupus Erythematosus 70%
  • Remission Induction 65%
  • Immunotherapy 44%
  • Pharmaceutical Preparations 41%
  32 Citations (Scopus)
• 2012

  CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice.

  Moser, K., Kalies, K., Szyska, M., Humrich, J. Y., Amann, K. & Manz, R. A., 04.2012, In: Arthritis and Rheumatism. 64, 4, p. 1237-1246 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Inbred NZB Mouse 100%
  • Lupus Nephritis 79%
  • Autoantibodies 60%
  • Immunoglobulin G 49%
  • Systemic Lupus Erythematosus 41%
  24 Citations (Scopus)
• 2011

  Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus

  Engler, J. B., Undeutsch, R., Kloke, L., Rosenberger, S., Backhaus, M., Schneider, U., Egerer, K., Dragun, D., Hofmann, J., Huscher, D., Burmester, G. R., Humrich, J. Y., Enghard, P. & Riemekasten, G., 12.2011, In: Annals of the Rheumatic Diseases. 70, 12, p. 2176-2183 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T-Lymphocytes 100%
  • Systemic Lupus Erythematosus 94%
  • T-Lymphocytes 62%
  • Autoantigens 24%
  • Nuclear Antigens 14%
  12 Citations (Scopus)
• 2010

  Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development

  Enghard, P., Humrich, J. Y., Chu, V. T., Grussie, E., Hiepe, F., Burmester, G. R., Radbruch, A., Berek, C. & Riemekasten, G., 06.2010, In: European Journal of Immunology. 40, 6, p. 1809-1818 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • B-lymphocytes 100%
  • lupus erythematosus 62%
  • mice 58%
  • pathogenesis 36%
  • spleen 34%
  31 Citations (Scopus)

• Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus

  Humrich, J. Y., Morbach, H., Undeutsch, R., Enghard, P., Rosenberger, S., Weigert, O., Kloke, L., Heimann, J., Gaber, T., Brandenburg, S., Scheffold, A., Huehn, J., Radbruch, A., Burmester, G. R. & Riemekasten, G., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 204-209 6 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T-Lymphocytes 100%
  • Interleukin-2 89%
  • Systemic Lupus Erythematosus 37%
  • Disease Progression 32%
  • T-Lymphocytes 12%
  98 Citations (Scopus)
• 2009

  CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients

  Enghard, P., Humrich, J. Y., Rudolph, B., Rosenberger, S., Biesen, R., Kuhn, A., Manz, R., Hiepe, F., Radbruch, A., Burmester, G. R. & Riemekasten, G., 01.01.2009, In: Arthritis and Rheumatism. 60, 1, p. 199-206 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Nephritis 100%
  • Systemic Lupus Erythematosus 78%
  • Urine 59%
  • Biomarkers 54%
  • T-Lymphocytes 51%
  82 Citations (Scopus)
• 2008

  Autoregulation of Th1-mediated inflammation by twist1

  Niesner, U., Albrecht, I., Janke, M., Doebis, C., Loddenkemper, C., Lexberg, M. H., Eulenburg, K., Kreher, S., Koeck, J., Baumgrass, R., Bonhagen, K., Kamradt, T., Enghard, P., Humrich, J. Y., Rutz, S., Schulze-Topphoff, U., Aktas, O., Bartfeld, S., Radbruch, H., Hegazy, A. N., & 18 othersLöhning, M., Baumgart, D. C., Duchmann, R., Rudwaleit, M., Häupl, T., Gitelman, I., Krenn, V., Gruen, J., Sieper, J., Zeitz, M., Wiedenmann, B., Zipp, F., Hamann, A., Janitz, M., Scheffold, A., Burmester, G. R., Chang, H. D. & Radbruch, A., 04.08.2008, In: Journal of Experimental Medicine. 205, 8, p. 1889-1901 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Helper-Inducer T-Lymphocytes 100%
  • Homeostasis 70%
  • Inflammation 56%
  • STAT4 Transcription Factor 41%
  • Psychological Imprinting 34%
  69 Citations (Scopus)
• 2007

  Vaccinia virus impairs directional migration and chemokine receptor switch of human dendritic cells

  Humrich, J. Y., Thumann, P., Greiner, S., Humrich, J. H., Averbeck, M., Schwank, C., Kämpgen, E., Schuler, G. & Jenne, L., 04.2007, In: European Journal of Immunology. 37, 4, p. 954-965 12 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Vaccinia virus 100%
  • Chemokine Receptors 93%
  • Dendritic Cells 74%
  • Chemokine CCL19 23%
  • Viral Interference 23%
  25 Citations (Scopus)
• 2006

  Mature monocyte-derived dendritic cells respond more strongly to CCL19 than to CXCL12: Consequences for directional migration

  Humrich, J. Y., Humrich, J. H., Averbeck, M., Thumann, P., Termeer, C., Kämpgen, E., Schuler, G. & Jenne, L., 02.2006, In: Immunology. 117, 2, p. 238-247 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Dendritic Cells 100%
  • Monocytes 92%
  • Chemokine Receptors 78%
  • Ligands 19%
  • Proto-Oncogene Proteins c-akt 16%
  31 Citations (Scopus)

• The highly attenuated vaccinia virus strain modified virus Ankara induces apoptosis in melanoma cells and allows bystander dendritic cells to generate a potent anti-tumoral immunity

  Greiner, S., Humrich, J. Y., Thuman, P., Sauter, B., Schuler, G. & Jenne, L., 11.2006, In: Clinical and Experimental Immunology. 146, 2, p. 344-353 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Vaccinia virus 100%
  • Dendritic Cells 74%
  • Melanoma 69%
  • Immunity 68%
  • Viruses 55%
  44 Citations (Scopus)
• 2004

  Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells

  Riemekasten, G., Langnickel, D., Enghard, P., Undeutsch, R., Humrich, J., Ebling, F. M., Hocher, B., Humaljoki, T., Neumayer, H., Burmester, G. R., Hahn, B. H., Radbruch, A. & Hiepe, F., 01.11.2004, In: Journal of Immunology. 173, 9, p. 5835-5842 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Regulatory T-Lymphocytes 100%
  • Intravenous Injections 96%
  • T-Lymphocytes 62%
  • Autoantibodies 46%
  • Proteins 37%
  34 Citations (Scopus)
• 2003

  Antigen loading of dendritic cells with whole tumor cell preparations

  Thumann, P., Moc, I., Humrich, J., Berger, T. G., Schultz, E. S., Schuler, G. & Jenne, L., 01.06.2003, In: Journal of Immunological Methods. 277, 1-2, p. 1-16 16 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Dendritic Cells 100%
  • Antigens 70%
  • Neoplasms 36%
  • Cryopreservation 30%
  • Human Influenza 15%
  72 Citations (Scopus)