Inken Wohlers

Research output

Research Output per year 2009 2009 2011 2013 2014 2015 2018 2019 2020 2021 2022 2023 2023

• 26 Journal articles
• 2 Conference Papers
• 2 Letters
• 1 Conference contribution
• 2 More
  • 1 Conference Articles in Journals
  • 1 Scientific review articles

Research Output per year

Research Output per year

Search results

• 2023

  A comprehensive analysis of genetic risk for metabolic syndrome in the Egyptian population via allele frequency investigation and Missense3D predictions

  Bassyouni, M., Mysara, M., Wohlers, I., Busch, H., Saber-Ayad, M. & El-Hadidi, M., 12.2023, In: Scientific Reports. 13, 1, 20517.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene 100%
  • Gene Frequency 100%
  • Genetic Risk 100%
  • Protein 50%
  • Genotype 50%

• A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs

  Thomsen, M., Künstner, A., Wohlers, I., Olbrich, M., Lenfers, T., Osumi, T., Shimazaki, Y., Nishifuji, K., Ibrahim, S. M., Watson, A., Busch, H. & Hirose, M., 21.10.2023, In: Microbiome. 11, 1, p. 232

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Intestine Flora 100%
  • Atopic Dermatitis 100%
  • Skin Flora 100%
  • Dog 100%
  • Canine Atopic Dermatitis 100%

• North and East African mitochondrial genetic variation needs further characterization towards precision medicine

  Fähnrich, A., Stephan, I., Hirose, M., Haarich, F., Awadelkareem, M. A., Ibrahim, S., Busch, H. & Wohlers, I., 12.2023, In: Journal of advanced research. 54, p. 59-76 18 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Haplogroup 100%
  • Homeostasis 25%
  • Mitochondrion 25%
  • Sequencing 25%
  • Mitochondrial DNA 25%
• 2022

  A survey of genome-wide association studies, polygenic scores and UK Biobank highlights resources for autoimmune disease genetics

  Saurabh, R., Fouodo, C. J. K., König, I. R., Busch, H. & Wohlers, I., 05.08.2022, In: Frontiers in Immunology. 13, 972107.

  Research output: Journal Articles › Scientific review articles › Research

  • Genetic Disorder 100%
  • Polygenic Score 100%
  • Autoimmune Disease 100%
  • Next Generation Sequencing 40%
  • Genotyping 20%
  2 Citations (Scopus)

• Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in TAF1 with Nanopore Sequencing

  Lüth, T., Laβ, J., Schaake, S., Wohlers, I., Pozojevic, J., Jamora, R. D. G., Rosales, R. L., Brüggemann, N., Saranza, G., Diesta, C. C. E., Schlüter, K., Tse, R., Reyes, C. J., Brand, M., Busch, H., Klein, C., Westenberger, A. & Trinh, J., 11.01.2022, In: Genes. 13, 1, 126.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Sequencing 100%
  • Methylation 100%
  • Retrotransposon 100%
  • Variable Number Tandem Repeat 100%
  • Parkinsonism 100%

• Genetic analysis of CFH and MCP in Egyptian patients with immune-complex proliferative glomerulonephritis

  Gouda, H. R., Talaat, I. M., Bouzid, A., El-Assi, H., Nabil, A., Venkatachalam, T., Manasa Bhamidimarri, P., Wohlers, I., Mahdami, A., EL-Gendi, S., ElKoraie, A., Busch, H., Saber-Ayad, M., Hamoudi, R. & Baddour, N., 23.09.2022, In: Frontiers in Immunology. 13, 960068.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Patient 100%
  • Glomerulonephritis 100%
  • Genetic Analysis 100%
  • Mesangial Proliferative Glomerulonephritis 100%
  • Immune Complex 100%
  1 Citation (Scopus)
• 2021

  Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani

  Ohms, M., Ferreira, C., Busch, H., Wohlers, I., Guerra de Souza, A. C., Silvestre, R. & Laskay, T., 19.03.2021, In: Frontiers in Immunology. 12, p. 632512 632512.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Neutrophil 100%
  • Leishmania donovani 100%
  • Parasite 25%
  • Visceral Leishmaniasis 25%
  • Leishmania 16%

• In silico candidate variant and gene identification using inbred mouse strains

  Munz, M., Khodaygani, M., Aherrahrou, Z., Busch, H. & Wohlers, I., 11.03.2021, In: PeerJ. 9, p. e11017 11017.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene 100%
  • Inbred Mouse Strain 100%
  • Genotyping 42%
  • Genetic Heterogeneity 14%
  • T Cell 14%

• Whole-genome sequencing reveals new Alzheimer's disease–associated rare variants in loci related to synaptic function and neuronal development

  Alzheimer's Disease Neuroimaging Initiative (ADNI), 2021, In: Alzheimer's and Dementia.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Whole Genome Sequencing 100%
  • Rare Variant 100%
  • Gene 20%
  • Contrast 20%
  • Aptitude 20%
  1 Citation (Scopus)
• 2020

  Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines

  Wohlers, I., Schulz, C., Kilpert, F. & Bertram, L., 02.2020, In: Neurobiology of Aging. 86, p. 202.e1-202.e3

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Single Nucleotide Polymorphism 100%
  • MicroRNA 100%
  • Expression Quantitative Trait Loci 28%
  • Regulatory Mechanism 14%
  • Sequencing 14%

• An integrated personal and population-based Egyptian genome reference

  Wohlers, I., Künstner, A., Munz, M., Olbrich, M., Fähnrich, A., Calonga-Solís, V., Ma, C., Hirose, M., El-Mosallamy, S., Salama, M., Busch, H. & Ibrahim, S., 18.09.2020, In: Nature Communications. 11, 1, p. 4719 4719.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene Frequency 100%
  • Genetic Disorder 100%
  • Polygenic Score 100%
  • Gene Linkage Disequilibrium 100%
  • Whole Genome Sequencing 100%

• CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort

  Jünger, S. T., Andreiuolo, F., Mynarek, M., Wohlers, I., Rahmann, S., Klein-Hitpass, L., Dörner, E., zur Mühlen, A., Velez-Char, N., von Hoff, K., Warmuth-Metz, M., Kortmann, R. D., Timmermann, B., von Bueren, A., Rutkowski, S. & Pietsch, T., 01.09.2020, In: Acta Neuropathologica. 140, 3, p. 405-407 3 p.

  Research output: Journal Articles › Letters › peer-review

  1 Citation (Scopus)

• Qtlizer: comprehensive QTL annotation of GWAS results

  Munz, M., Wohlers, I., Simon, E., Reinberger, T., Busch, H., Schaefer, A. S. & Erdmann, J., 24.11.2020, In: Scientific Reports. 10, 1, 20417.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gene 100%
  • Genome Wide Association Study 100%
  • Expression Quantitative Trait Loci 66%
  • Database 50%
  • Protein 16%
  1 Citation (Scopus)
• 2019

  Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid

  Takousis, P., Sadlon, A., Schulz, J., Wohlers, I., Dobricic, V., Middleton, L., Lill, C. M., Perneczky, R. & Bertram, L., 11.2019, In: Alzheimer's and Dementia. 15, 11, p. 1468-1477 10 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Blood 100%
  • Brain 100%
  • microRNA 100%
  • Cerebrospinal Fluid 100%
  • Meta-Analysis 25%
  10 Citations (Scopus)

• Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features - A retrospective analysis of the HIT ependymoma trial cohort

  Jünger, S. T., Mynarek, M., Wohlers, I., Dörner, E., Mühlen, A. Z., Velez-Char, N., Von Hoff, K., Rutkowski, S., Warmuth-Metz, M., Kortmann, R. D., Timmermann, B., Rahmann, S., Klein-Hitpass, L., Von Bueren, A. O. & Pietsch, T., 14.11.2019, In: Acta Neuropathologica Communications. 7, 1, 181.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Analysis 100%
  • Risk Stratification 100%
  • Posterior Fossa 100%
  • Mitosis Rate 100%
  • Posterior Cranial Fossa 100%
  2 Citations (Scopus)

• Meta-analyses identify differentially expressed micrornas in Parkinson's disease

  Schulz, J., Takousis, P., Wohlers, I., Itua, I. O. G., Dobricic, V., Rücker, G., Binder, H., Middleton, L., Ioannidis, J. P. A., Perneczky, R., Bertram, L. & Lill, C. M., 06.2019, In: Annals of Neurology. 85, 6, p. 835-851 17 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • MicroRNA 100%
  • Parkinson's Disease 100%
  • Liquid 75%
  • Brain 50%
  • Screening 25%
  17 Citations (Scopus)
• 2018

  Bioconda: Sustainable and comprehensive software distribution for the life sciences

  Dale, R., Grüning, B., Sjödin, A., Rowe, J., Chapman, B. A., Tomkins-Tinch, C. H., Valieris, R., Batut, B., Caprez, A., Cokelaer, T., Yusuf, D., Beauchamp, K. A., Brinda, K., Wollmann, T., Corguillé, G. L., Ryan, D., Bretaudeau, A., Hoogstrate, Y., Pedersen, B. S. & Heeringen, S. V. & 131 others, Raden, M., Luna-Valero, S., Soranzo, N., Smet, M. D., Kuster, G. V., Kirchner, R., Pantano, L., Charlop-Powers, Z., Thornton, K., Martin, M., Beek, M. V. D., Maticzka, D., Miladi, M., Will, S., Gravouil, K., Unneberg, P., Brueffer, C., Blank, C., Piro, V. C., Wolff, J., Antao, T., Gladman, S., Shlyakhter, I., Hollander, M. D., Mabon, P., Shen, W., Boekel, J., Holtgrewe, M., Bouvier, D., de Ruiter, J. R., Cabral, J., Choudhary, S., Harding, N., Kleinkauf, R., Enns, E., Eggenhofer, F., Brown, J., Cock, P. J. A., Timm, H., Thomas, C., Zhang, X. O., Chambers, M., Turaga, N., Seiler, E., Brislawn, C., Pruesse, E., Fallmann, J., Kelleher, J., Nguyen, H., Parsons, L., Fang, Z., Stovner, E. B., Stoler, N., Ye, S., Wohlers, I., Farouni, R., Freeberg, M., Johnson, J. E., Bargull, M., Kensche, P. R., Webster, T. H., Eppley, J. M., Stahl, C., Rose, A. S., Reynolds, A., Wang, L. B., Garnier, X., Dirmeier, S., Knudsen, M., Taylor, J., Srivastava, A., Rai, V., Agren, R., Junge, A., Guimera, R. V., Khan, A., Schmeier, S., He, G., Pinello, L., Hägglund, E., Mikheyev, A. S., Preussner, J., Waters, N. R., Li, W., Capellades, J., Chande, A. T., Pirola, Y., Hiltemann, S., Bendall, M. L., Singh, S., Dunn, W. A., Drouin, A., Domenico, T. D., Bruijn, I. D., Larson, D. E., Chicco, D., Grassi, E., Gonnella, G., B, J., Wang, L., Giacomoni, F., Clarke, E., Blankenberg, D., Tran, C., Patro, R., Laurent, S., Gopez, M., Sennblad, B., Baaijens, J. A., Ewels, P., Wright, P. R., Enache, O. M., Roger, P., Dampier, W., Koppstein, D., Devisetty, U. K., Rausch, T., Cornwell, M., Salatino, A. E., Seiler, J., Jung, M., Kornobis, E., Cumbo, F., Stöcker, B. K., Moskalenko, O., Bogema, D. R., Workentine, M. L., Newhouse, S. J., Leprevost, F. D. V., Arvai, K. & Köster, J., 01.07.2018, In: Nature Methods. 15, 7, p. 475-476 2 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  150 Citations (Scopus)

• Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics

  Wohlers, I., Bertram, L. & Lill, C. M., 11.2018, In: Journal of Autoimmunity. 94, p. 83-89 7 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Autoimmune Disease 100%
  • MicroRNA 100%
  • Genome-Wide Association Study 71%
  • Single Nucleotide Polymorphism 33%
  • Inflammatory Arthritis 28%
  3 Citations (Scopus)

• Taking genomics research to the next level: The Genotype-Tissue expression project

  Wohlers, I. & Bertram, L., 07.2018, In: Movement Disorders. 33, 7, p. 1097 1 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  1 Citation (Scopus)
• 2016

  Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia

  Johansson, P., Bergmann, A., Rahmann, S., Wohlers, I., Scholtysik, R., Przekopowitz, M., Seifert, M., Tschurtschenthaler, G., Webersinke, G., Jäger, U., Siebert, R., Klein-Hitpass, L., Dührsen, U., Dürig, J. & Küppers, R., 01.01.2016, In: International Journal of Cancer. 138, 1, p. 121-124 4 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • T Cell 100%
  • Tumor Necrosis Factor Alpha Induced Protein 3 100%
  • Lesion 33%
  • Patient 16%
  • Pathogenesis 16%
  22 Citations (Scopus)
• 2015

  Automatic classification of protein structure using the maximum contact map overlap metric

  Andonov, R., Djidjev, H., Klau, G. W., Boudic-Jamin, M. L. & Wohlers, I., 01.01.2015, In: Algorithms. 8, 4, p. 850-869 20 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Gold Standard 50%

• Genome-wide significant association with seven novel multiple sclerosis risk loci

  Lill, C. M., Luessi, F., Alcina, A., Sokolova, E. A., Ugidos, N., de la Hera, B., Guillot-Noël, L., Malhotra, S., Reinthaler, E., Schjeide, B. M. M., Mescheriakova, J. Y., Mashychev, A., Wohlers, I., Akkad, D. A., Aktas, O., Alloza, I., Antigüedad, A., Arroyo, R., Astobiza, I. & Blaschke, P. & 42 others, Boyko, A. N., Buttmann, M., Chan, A., Dörner, T., Epplen, J. T., Favorova, O. O., Fedetz, M., Fernández, O., García-Martínez, A., Gerdes, L. A., Graetz, C., Hartung, H. P., Hoffjan, S., Izquierdo, G., Korobko, D. S., Kroner, A., Kubisch, C., Kümpfel, T., Leyva, L., Lohse, P., Malkova, N. A., Montalban, X., Popova, E. V., Rieckmann, P., Rozhdestvenskii, A. S., Schmied, C., Smagina, I. V., Tsareva, E. Y., Winkelmann, A., Zettl, U. K., Binder, H., Cournu-Rebeix, I., Hintzen, R., Zimprich, A., Comabella, M., Fontaine, B., Urcelay, E., Vandenbroeck, K., Filipenko, M., Matesanz, F., Zipp, F. & Bertram, L., 01.01.2015, In: Journal of Medical Genetics. 52, 12, p. 848-855 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Single Nucleotide Polymorphism 100%
  • Gene 33%
  • Genetic Association 33%
  • Genetic Risk 33%
  16 Citations (Scopus)
• 2014

  Exact Protein Structure Classification Using the Maximum Contact Map Overlap Metric

  Wohlers, I., Le Boudic-Jamin, M., Djidjev, H., Klau, G. W. & Andonov, R., 2014, AlCoB 2014: Algorithms for Computational Biology. Springer, Cham, Vol. 8542. p. 262-273 12 p. (Lecture Notes in Computer Science; vol. 8542).

  Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

  • Gold Standard 100%

• Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway

  Pietsch, T., Wohlers, I., Goschzik, T., Dreschmann, V., Denkhaus, D., Dörner, E., Rahmann, S. & Klein-Hitpass, L., 04.2014, In: Acta Neuropathologica. 127, 4, p. 609-611 3 p.

  Research output: Journal Articles › Letters › peer-review

  71 Citations (Scopus)
• 2013

  DALIX: Optimal DALI protein structure alignment

  Wohlers, I., Andonov, R. & Klau, G. W., 2013, In: IEEE/ACM Transactions on Computational Biology and Bioinformatics. 10, 1, p. 26-36 11 p., 6365174.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Structure Alignment 100%
  • Protein Structure 100%
  • Protein 66%
  • Algorithms 50%
  • Distance Matrix 50%
  9 Citations (Scopus)

• Mapping proteins in the presence of paralogs using units of coevolution.

  El-Kebir, M., Marschall, T., Wohlers, I., Patterson, M., Heringa, J., Schönhuth, A. & Klau, G. W., 2013, In: BMC Bioinformatics. 14 Suppl 15, p. S18 S18.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Score 100%
  • Prediction 100%
  • Maximum Likelihood 100%
  • Computational Approach 100%
  • Quadratic Programming 100%
  2 Citations (Scopus)
• 2012

  CSA: Comprehensive comparison of pairwise protein structure alignments

  Wohlers, I., Malod-Dognin, N., Andonov, R. & Klau, G. W., 07.2012, In: Nucleic Acids Research. 40, W1, p. W303-W309

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Protein Structure 100%
  • Protein 50%
  12 Citations (Scopus)
• 2011

  Algorithm engineering for optimal alignment of protein structure distance matrices

  Wohlers, I., Andonov, R. & Klau, G. W., 08.2011, In: Optimization Letters. 5, 3, p. 421-433 13 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Algorithms 100%
  • Optimal Alignment 100%
  • Distance Matrix 100%
  • Algorithm 100%
  • Scoring Function 50%
  9 Citations (Scopus)

• Sparsifying distance matrices for protein-protein structure alignments

  Mucherino, A., Wohlers, I., Klau, G. W. & Andonov, R., 2011, p. 211 - 214. 4 p.

  Research output: Contribution to conference › Conference Papers › peer-review

  • Similarity 100%
  • Native Protein 100%
  • Structure Alignment 100%
  • Distance Matrix 100%
  • Protein Conformation 33%
• 2010

  Towards optimal alignment of protein structure distance matrices

  Wohlers, I., Domingues, F. S., Klau, G. W. & Tramontano, A., 17.07.2010, In: Bioinformatics (Oxford, England). 26, 18, p. 2273–2280 8 p.

  Research output: Journal Articles › Conference Articles in Journals › Research › peer-review

  • Algorithms 100%
  • Optimal Alignment 100%
  • Distance Matrix 100%
  • Structural Alignment 100%
  • Protein Structure 100%
• 2009

  Aligning protein structures using distance matrices and combinatorial optimization

  Wohlers, I., Petzold, L., Domingues, F. S. & Klau, G. W., 2009, p. 33 - 43. 11 p.

  Research output: Contribution to conference › Conference Papers › peer-review

  • Structural Alignment 100%
  • Relaxation 100%
  • Protein 70%
  • Accuracy 25%
  • Atom 20%

• PAUL: Protein structural alignment using integer linear programming and Lagrangian relaxation

  Wohlers, I., Petzold, L., Domingues, F. S. & Klau, G. W., 27.06.2009, In: BMC Bioinformatics. 10, SUPPL. 13, p. P2 P2.

  Research output: Journal Articles › Journal articles › Research › peer-review

  6 Citations (Scopus)

• The Characterization Tool: A knowledge-based stem cell, differentiated cell, and tissue database with a web-based analysis front-end

  Wohlers, I., Stachelscheid, H., Borstlap, J., Zeilinger, K. & Gerlach, J. C., 09.2009, In: Stem Cell Research. 3, 2-3, p. 88-95 8 p.

  Research output: Journal Articles › Journal articles › Research › peer-review

  • Front Analysis 100%
  • Database 100%
  • Differentiated Cell 100%
  • Front End 100%
  • Stem Cell 100%
  5 Citations (Scopus)