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  • 2022

    Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

    Biobank Japan, 2022, In: Nature Genetics. 54, 12, p. 1803-1815 13 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Genetic and modifiable risk factors combine multiplicatively in common disease

    Pang, S., Yengo, L., Nelson, C. P., Bourier, F., Zeng, L., Li, L., Kessler, T., Erdmann, J., Mägi, R., Läll, K., Metspalu, A., Mueller-Myhsok, B., Samani, N. J., Visscher, P. M. & Schunkert, H., 2022, In: Clinical Research in Cardiology.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    Cardiogram CVD & Erdmann, J., 2022, In: Genome Biology. 23, 1, p. 268

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Negative Impact of the UEFA European Soccer Championship on Central Hemodynamics and Arterial Stiffness: A Multicenter Study

    Franzen, K. F., Mortensen, K., Ott, C., Herber, K., Busse, M., Söling, C., Schneppe, D., Lässig, S., Dörr, M., Tilz, R., Drömann, D., Schunkert, H. & Reppel, M., 11.2022, In: Life. 12, 11, 1696.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • 2021

    A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy

    Wierer, M., Werner, J., Wobst, J., Kastrati, A., Cepele, G., Aherrahrou, R., Sager, H. B., Erdmann, J., Dichgans, M., Flockerzi, V., Civelek, M., Dietrich, A., Mann, M., Schunkert, H. & Kessler, T., 07.05.2021, In: European Heart Journal. 42, 18, p. 1773-1785 13 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    2 Citations (Scopus)
  • Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family

    Dang, T. A., Kessler, T., Wobst, J., Wierer, M., Braenne, I., Strom, T. M., Tennstedt, S., Sager, H. B., Meitinger, T., Erdmann, J. & Schunkert, H., 23.08.2021, In: Circulation. p. 662-665 4 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    1 Citation (Scopus)
  • The power of genetic diversity in genome-wide association studies of lipids

    VA Million Veteran Program, 2021, In: Nature. 600, 7890, p. 675-679 5 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • 2020

    A missense variant in mitochondrial amidoxime reducing component 1 gene and protection against liver disease

    Million Veteran Program, 04.2020, In: PLoS Genetics. 16, 4, p. e1008629 e1008629.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Genetics of educational attainment and coronary risk in Mendelian randomization studies

    Schunkert, H., Erdmann, J., Samani, N. J., Deloukas, P. & Zeng, L., 14.02.2020, In: European Heart Journal. 41, 7, p. 894-895 2 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

    Zheng, Y., Huang, T., Wang, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J. F., Sim, X., van Dam, R. M., Tai, E. S., Koh, W. P., Dorajoo, R., Saw, S. M., Sabanayagam, C., Wong, T. Y., Gupta, P., Rossing, P., Ahluwalia, T. S., Vinding, R. K., & 98 othersBisgaard, H., Bønnelykke, K., Wang, Y., Graff, M., Voortman, T., van Rooij, F. J. A., Hofman, A., van Heemst, D., Noordam, R., Estampador, A. C., Varga, T. V., Enzenbach, C., Scholz, M., Thiery, J., Burkhardt, R., Orho-Melander, M., Schulz, C. A., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpeläinen, T. O., Hansen, T., Kleber, M. E., Delgado, G., McCarthy, M., Lemaitre, R. N., Felix, J. F., Jaddoe, V. W. V., Wu, Y., Mohlke, K. L., Lehtimäki, T., Wang, C. A., Pennell, C. E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L. A., Lai, C. Q., Pitkänen, N., Boreham, C. A., Ridker, P. M., Rosendaal, F. R., de Mutsert, R., Power, C., Paternoster, L., Sørensen, T. I. A., Tjønneland, A., Overvad, K., Djousse, L., Rivadeneira, F., Lee, N. R., Raitakari, O. T., Kähönen, M., Viikari, J., Langhendries, J. P., Escribano, J., Verduci, E., Dedoussis, G., König, I., Balkau, B., Coltell, O., Dallongeville, J., Meirhaeghe, A., Amouyel, P., Gottrand, F., Pahkala, K., Niinikoski, H., Hyppönen, E., März, W., Mackey, D. A., Gruszfeld, D., Tucker, K. L., Fumeron, F., Estruch, R., Ordovas, J. M., Arnett, D. K., Mook-Kanamori, D. O., Mozaffarian, D., Psaty, B. M., North, K. E., Chasman, D. I. & Qi, L., 01.07.2020, In: European Journal of Epidemiology. 35, 7, p. 685-697 13 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • MiR-128a acts as a regulator in cardiac development by modulating differentiation of cardiac progenitor cell populations

    Hoelscher, S. C., Stich, T., Diehm, A., Lahm, H., Dreßen, M., Zhang, Z., Neb, I., Aherrahrou, Z., Erdmann, J., Schunkert, H., Santamaria, G., Cuda, G., Gilsbach, R., Hein, L., Lange, R., Hassel, D., Krane, M. & Doppler, S. A., 10.02.2020, In: International Journal of Molecular Sciences. 21, 3, 1158.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    1 Citation (Scopus)
  • Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status

    Gola, D., Erdmann, J., Müller-Myhsok, B., Schunkert, H. & König, I. R., 01.03.2020, In: Genetic Epidemiology. 44, 2, p. 125-138 14 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Population Bias in Polygenic Risk Prediction Models for Coronary Artery Disease

    Gola, D., Erdmann, J., Läll, K., Mägi, R., Müller-Myhsok, B., Schunkert, H. & König, I. R., 2020, In: Circulation: Genomic and Precision Medicine. p. 569-575 7 p., 002932.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    1 Citation (Scopus)
  • SARS-CoV-2 Infection in Asymptomatic Patients Hospitalized for Cardiac Emergencies: Implications for Patient Management

    Kessler, T., Wiebe, J., Graf, T., Schunkert, H., Kastrati, A. & Sager, H. B., 2020, In: Frontiers in Cardiovascular Medicine. 7, p. 599299

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • 2019

    A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A

    Demal, T. J., Heise, M., Reiz, B., Dogra, D., Brænne, I., Reichenspurner, H., Männer, J., Aherrahrou, Z., Schunkert, H., Erdmann, J. & Abdelilah-Seyfried, S., 01.12.2019, In: Scientific Reports. 9, 1, 2959.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Assessing the causal association of glycine with risk of cardio-metabolic diseases

    Wittemans, L. B. L., Lotta, L. A., Oliver-Williams, C., Stewart, I. D., Surendran, P., Karthikeyan, S., Day, F. R., Koulman, A., Imamura, F., Zeng, L., Erdmann, J., Schunkert, H., Khaw, K. T., Griffin, J. L., Forouhi, N. G., Scott, R. A., Wood, A. M., Burgess, S., Howson, J. M. M., Danesh, J., & 3 othersWareham, N. J., Butterworth, A. S. & Langenberg, C., 01.12.2019, In: Nature Communications. 10, 1, 1060.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    9 Citations (Scopus)
  • Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention

    Kessler, T., Wolf, B., Eriksson, N., Kofink, D., Mahmoodi, B. K., Rai, H., Tragante, V., Åkerblom, A., Becker, R. C., Bernlochner, I., Bopp, R., James, S., Katus, H. A., Mayer, K., Munz, M., Nordio, F., O'Donoghue, M. L., Sager, H. B., Sibbing, D., Solakov, L., & 11 othersStorey, R. F., Wobst, J., Asselbergs, F. W., Byrne, R. A., Erdmann, J., Koenig, W., Laugwitz, K. L., Ten Berg, J. M., Wallentin, L., Kastrati, A. & Schunkert, H., 2019, In: Cardiovascular Research. 115, 10, p. 1512-1518 7 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    7 Citations (Scopus)
  • Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

    DISCO Consortium & CARDIoGRAMPlusC4D Study Group, 08.01.2019, In: Journal of the American College of Cardiology. 73, 1, p. 58-66 9 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    33 Citations (Scopus)
  • Associations of autozygosity with a broad range of human phenotypes

    Clark, D. W., Okada, Y., Moore, K. H. S., Mason, D., Pirastu, N., Gandin, I., Mattsson, H., Barnes, C. L. K., Lin, K., Zhao, J. H., Deelen, P., Rohde, R., Schurmann, C., Guo, X., Giulianini, F., Zhang, W., Medina-Gomez, C., Karlsson, R., Bao, Y., Bartz, T. M., & 416 othersBaumbach, C., Biino, G., Bixley, M. J., Brumat, M., Chai, J. F., Corre, T., Cousminer, D. L., Dekker, A. M., Eccles, D. A., van Eijk, K. R., Fuchsberger, C., Gao, H., Germain, M., Gordon, S. D., de Haan, H. G., Harris, S. E., Hofer, E., Huerta-Chagoya, A., Igartua, C., Jansen, I. E., Jia, Y., Kacprowski, T., Karlsson, T., Kleber, M. E., Li, S. A., Li-Gao, R., Mahajan, A., Matsuda, K., Meidtner, K., Meng, W., Montasser, M. E., van der Most, P. J., Munz, M., Nutile, T., Palviainen, T., Prasad, G., Prasad, R. B., Priyanka, T. D. S., Rizzi, F., Salvi, E., Sapkota, B. R., Shriner, D., Skotte, L., Smart, M. C., Smith, A. V., van der Spek, A., Spracklen, C. N., Strawbridge, R. J., Tajuddin, S. M., Trompet, S., Turman, C., Verweij, N., Viberti, C., Wang, L., Warren, H. R., Wootton, R. E., Yanek, L. R., Yao, J., Yousri, N. A., Zhao, W., Adeyemo, A. A., Afaq, S., Aguilar-Salinas, C. A., Akiyama, M., Albert, M. L., Allison, M. A., Alver, M., Aung, T., Azizi, F., Bentley, A. R., Boeing, H., Boerwinkle, E., Borja, J. B., de Borst, G. J., Bottinger, E. P., Broer, L., Campbell, H., Chanock, S., Chee, M. L., Chen, G., Chen, Y. D. I., Chen, Z., Chiu, Y. F., Cocca, M., Collins, F. S., Concas, M. P., Corley, J., Cugliari, G., van Dam, R. M., Damulina, A., Daneshpour, M. S., Day, F. R., Delgado, G. E., Dhana, K., Doney, A. S. F., Dörr, M., Doumatey, A. P., Dzimiri, N., Ebenesersdóttir, S. S., Elliott, J., Elliott, P., Ewert, R., Felix, J. F., Fischer, K., Freedman, B. I., Girotto, G., Goel, A., Gögele, M., Goodarzi, M. O., Graff, M., Granot-Hershkovitz, E., Grodstein, F., Guarrera, S., Gudbjartsson, D. F., Guity, K., Gunnarsson, B., Guo, Y., Hagenaars, S. P., Haiman, C. A., Halevy, A., Harris, T. B., Hedayati, M., van Heel, D. A., Hirata, M., Höfer, I., Hsiung, C. A., Huang, J., Hung, Y. J., Ikram, M. A., Jagadeesan, A., Jousilahti, P., Kamatani, Y., Kanai, M., Kerrison, N. D., Kessler, T., Khaw, K. T., Khor, C. C., de Kleijn, D. P. V., Koh, W. P., Kolcic, I., Kraft, P., Krämer, B. K., Kutalik, Z., Kuusisto, J., Langenberg, C., Launer, L. J., Lawlor, D. A., Lee, I. T., Lee, W. J., Lerch, M. M., Li, L., Liu, J., Loh, M., London, S. J., Loomis, S., Lu, Y., Luan, J., Mägi, R., Manichaikul, A. W., Manunta, P., Másson, G., Matoba, N., Mei, X. W., Meisinger, C., Meitinger, T., Mezzavilla, M., Milani, L., Millwood, I. Y., Momozawa, Y., Moore, A., Morange, P. E., Moreno-Macías, H., Mori, T. A., Morrison, A. C., Muka, T., Murakami, Y., Murray, A. D., de Mutsert, R., Mychaleckyj, J. C., Nalls, M. A., Nauck, M., Neville, M. J., Nolte, I. M., Ong, K. K., Orozco, L., Padmanabhan, S., Pálsson, G., Pankow, J. S., Pattaro, C., Pattie, A., Polasek, O., Poulter, N., Pramstaller, P. P., Quintana-Murci, L., Räikkönen, K., Ralhan, S., Rao, D. C., van Rheenen, W., Rich, S. S., Ridker, P. M., Rietveld, C. A., Robino, A., van Rooij, F. J. A., Ruggiero, D., Saba, Y., Sabanayagam, C., Sabater-Lleal, M., Sala, C. F., Salomaa, V., Sandow, K., Schmidt, H., Scott, L. J., Scott, W. R., Sedaghati-Khayat, B., Sennblad, B., van Setten, J., Sever, P. J., Sheu, W. H. H., Shi, Y., Shrestha, S., Shukla, S. R., Sigurdsson, J. K., Sikka, T. T., Singh, J. R., Smith, B. H., Stančáková, A., Stanton, A., Starr, J. M., Stefansdottir, L., Straker, L., Sulem, P., Sveinbjornsson, G., Swertz, M. A., Taylor, A. M., Taylor, K. D., Terzikhan, N., Tham, Y. C., Thorleifsson, G., Thorsteinsdottir, U., Tillander, A., Tracy, R. P., Tusié-Luna, T., Tzoulaki, I., Vaccargiu, S., Vangipurapu, J., Veldink, J. H., Vitart, V., Völker, U., Vuoksimaa, E., Wakil, S. M., Waldenberger, M., Wander, G. S., Wang, Y. X., Wareham, N. J., Wild, S., Yajnik, C. S., Yuan, J. M., Zeng, L., Zhang, L., Zhou, J., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Becker, D. M., Lehne, B., Bennett, D. A., van den Berg, L. H., Berndt, S. I., Bharadwaj, D., Bielak, L. F., Bochud, M., Boehnke, M., Bouchard, C., Bradfield, J. P., Brody, J. A., Campbell, A., Carmi, S., Caulfield, M. J., Cesarini, D., Chambers, J. C., Chandak, G. R., Cheng, C. Y., Ciullo, M., Cornelis, M., Cusi, D., Smith, G. D., Deary, I. J., Dorajoo, R., van Duijn, C. M., Ellinghaus, D., Erdmann, J., Eriksson, J. G., Evangelou, E., Evans, M. K., Faul, J. D., Feenstra, B., Feitosa, M., Foisy, S., Franke, A., Friedlander, Y., Gasparini, P., Gieger, C., Gonzalez, C., Goyette, P., Grant, S. F. A., Griffiths, L. R., Groop, L., Gudnason, V., Gyllensten, U., Hakonarson, H., Hamsten, A., van der Harst, P., Heng, C. K., Hicks, A. A., Hochner, H., Huikuri, H., Hunt, S. C., Jaddoe, V. W. V., De Jager, P. L., Johannesson, M., Johansson, Å., Jonas, J. B., Jukema, J. W., Junttila, J., Kaprio, J., Kardia, S. L. R., Karpe, F., Kumari, M., Laakso, M., van der Laan, S. W., Lahti, J., Laudes, M., Lea, R. A., Lieb, W., Lumley, T., Martin, N. G., März, W., Matullo, G., McCarthy, M. I., Medland, S. E., Merriman, T. R., Metspalu, A., Meyer, B. F., Mohlke, K. L., Montgomery, G. W., Mook-Kanamori, D., Munroe, P. B., North, K. E., Nyholt, D. R., O’connell, J. R., Ober, C., Oldehinkel, A. J., Palmas, W., Palmer, C., Pasterkamp, G. G., Patin, E., Pennell, C. E., Perusse, L., Peyser, P. A., Pirastu, M., Polderman, T. J. C., Porteous, D. J., Posthuma, D., Psaty, B. M., Rioux, J. D., Rivadeneira, F., Rotimi, C., Rotter, J. I., Rudan, I., Den Ruijter, H. M., Sanghera, D. K., Sattar, N., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, R. A., Shuldiner, A. R., Sim, X., Small, N., Smith, J. A., Sotoodehnia, N., Tai, E. S., Teumer, A., Timpson, N. J., Toniolo, D., Tregouet, D. A., Tuomi, T., Vollenweider, P., Wang, C. A., Weir, D. R., Whitfield, J. B., Wijmenga, C., Wong, T. Y., Wright, J., Yang, J., Yu, L., Zemel, B. S., Zonderman, A. B., Perola, M., Magnusson, P. K. E., Uitterlinden, A. G., Kooner, J. S., Chasman, D. I., Loos, R. J. F., Franceschini, N., Franke, L., Haley, C. S., Hayward, C., Walters, R. G., Perry, J. R. B., Esko, T., Helgason, A., Stefansson, K., Joshi, P. K., Kubo, M. & Wilson, J. F., 01.12.2019, In: Nature Communications. 10, 1, 4957.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • CARDIoGRAM celebrates its 10th Anniversary

    Schunkert, H., Erdmann, J. & Samani, S. N. J., 01.06.2019, In: European Heart Journal. 40, 21, p. 1664-1666 3 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • DNA sequence variation in ACVR1C encoding the activin receptor-like kinase 7 influences body fat distribution and protects against type 2 diabetes

    Emdin, C. A., Khera, A. V., Aragam, K., Haas, M., Chaffin, M., Klarin, D., Natarajan, P., Bick, A., Zekavat, S. M., Nomura, A., Ardissino, D., Wilson, J. G., Schunkert, H., McPherson, R., Watkins, H., Elosua, R., Bown, M. J., Samani, N. J., Baber, U., Erdmann, J., & 5 othersGupta, N., Danesh, J., Saleheen, D., Gabriel, S. & Kathiresan, S., 01.01.2019, In: Diabetes. 68, 1, p. 226-234 9 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    2 Citations (Scopus)
  • Genetically modulated educational attainment and coronary disease risk

    Zeng, L., Ntalla, I., Kessler, T., Kastrati, A., Erdmann, J., Danesh, J., Watkins, H., Samani, N. J., Deloukas, P. & Schunkert, H., 08.2019, In: European Heart Journal. 40, 29, p. 2413-2420 8 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    9 Citations (Scopus)
  • LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study

    Silbernagel, G., Scharnagl, H., Kleber, M. E., Delgado, G., Stojakovic, T., Laaksonen, R., Erdmann, J., Rankinen, T., Bouchard, C., Landmesser, U., Schunkert, H., März, W. & Grammer, T. B., 03.2019, In: Atherosclerosis. 282, p. 37-44 8 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    10 Citations (Scopus)
  • Randomized trial of ticagrelor vs. aspirin in patients after coronary artery bypass grafting: The TiCAB trial

    Schunkert, H., Boening, A., Von Scheidt, M., Lanig, C., Gusmini, F., DeWaha, A., Kuna, C., Fach, A., Grothusen, C., Oberhoffer, M., Knosalla, C., Walther, T., Danner, B. C., Misfeld, M., Zeymer, U., Wimmer-Greinecker, G., Siepe, M., Grubitzsch, H., Joost, A., Schaefer, A., & 16 othersConradi, L., Cremer, J., Hamm, C., Lange, R., Radke, P. W., Schulz, R., Laufer, G., Grieshaber, P., Pader, P., Attmann, T., Schmoeckel, M., Meyer, A., Ziegelhoffer, T., Hambrecht, R., Kastrati, A. & Sandner, S. E., 01.08.2019, In: European Heart Journal. 40, 29, p. 2432-2440 9 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    2 Citations (Scopus)
  • Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease

    Peloso, G. M., Nomura, A., Khera, A. V., Chaffin, M., Won, H. H., Ardissino, D., Danesh, J., Schunkert, H., Wilson, J. G., Samani, N., Erdmann, J., McPherson, R., Watkins, H., Saleheen, D., McCarthy, S., Teslovich, T. M., Leader, J. B., Lester Kirchner, H., Marrugat, J., Nohara, A., & 6 othersKawashiri, M. A., Tada, H., Dewey, F. E., Carey, D. J., Baras, A. & Kathiresan, S., 01.05.2019, In: Circulation. Genomic and precision medicine. 12, 5, p. e002376

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    11 Citations (Scopus)
  • 2018

    Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

    Emdin, C. A., Khera, A. V., Chaffin, M., Klarin, D., Natarajan, P., Aragam, K., Haas, M., Bick, A., Zekavat, S. M., Nomura, A., Ardissino, D., Wilson, J. G., Schunkert, H., McPherson, R., Watkins, H., Elosua, R., Bown, M. J., Samani, N. J., Baber, U., Erdmann, J., & 21 othersGupta, N., Danesh, J., Chasman, D., Ridker, P., Denny, J., Bastarache, L., Lichtman, J. H., D'Onofrio, G., Mattera, J., Spertus, J. A., Sheu, W. H. H., Taylor, K. D., Psaty, B. M., Rich, S. S., Post, W., Rotter, J. I., Chen, Y. D. I., Krumholz, H., Saleheen, D., Gabriel, S. & Kathiresan, S., 01.12.2018, In: Nature Communications. 9, 1, 1613.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    16 Citations (Scopus)
  • Association of genetic variation at AQP4 locus with vascular depression

    Westermair, A. L., Munz, M., Schaich, A., Nitsche, S., Willenborg, B., Muñoz Venegas, L. M., Willenborg, C., Schunkert, H., Schweiger, U. & Erdmann, J., 12.2018, In: Biomolecules. 8, 4, 164.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    4 Citations (Scopus)
  • Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression

    Wierer, M., Prestel, M., Schiller, H. B., Yan, G., Schaab, C., Azghandi, S., Werner, J., Kessler, T., Malik, R., Murgia, M., Aherrahrou, Z., Schunkert, H., Dichgans, M. & Mann, M., 02.2018, In: Molecular and Cellular Proteomics. 17, 2, p. 321-334 14 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    13 Citations (Scopus)
  • Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation

    Bauer, C., Le Saux, O., Pomozi, V., Aherrahrou, R., Kriesen, R., Stölting, S., Liebers, A., Kessler, T., Schunkert, H., Erdmann, J. & Aherrahrou, Z., 01.12.2018, In: Scientific Reports. 8, 1, 5812.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    7 Citations (Scopus)
  • Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques

    METASTROKE Collaboration of the International Stroke Genetics Consortium, 01.09.2018, In: Circulation. Genomic and precision medicine. 11, 9, p. e002115

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    7 Citations (Scopus)
  • Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease

    Li, Y., Wang, D. W., Chen, Y., Chen, C., Guo, J., Zhang, S., Sun, Z., Ding, H., Yao, Y., Zhou, L., Xu, K., Song, C., Yang, F., Zhao, B., Yan, H., Wang, W. J., Wu, C., Lu, X., Yang, X., Dong, J., & 22 othersZheng, G., Tian, S., Cui, Y., Jin, L., Liu, G., Cui, H., Wang, S., Jiang, F., Wang, C., Erdmann, J., Zeng, L., Huang, S., Zhong, J., Ma, Y., Chen, W., Sun, J., Lei, W., Chen, S., Rao, S., Gu, D., Schunkert, H. & Tian, X. L., 01.04.2018, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 4, p. 964-975 12 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Mental health and psychosocial functioning over the lifespan of German patients undergoing cardiac catheterization for coronary artery disease

    Schaich, A., Westermair, A. L., Munz, M., Nitsche, S., Willenborg, B., Willenborg, C., Schunkert, H., Erdmann, J. & Schweiger, U., 27.07.2018, In: Frontiers in Psychiatry. 9, JUL, 338.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

    Lempiäinen, H., Brænne, I., Michoel, T., Tragante, V., Vilne, B., Webb, T. R., Kyriakou, T., Eichner, J., Zeng, L., Willenborg, C., Franzen, O., Ruusalepp, A., Goel, A., Van Der Laan, S. W., Biegert, C., Hamby, S., Talukdar, H. A., Foroughi Asl, H., Dichgans, M., Dreker, T., & 15 othersGraettinger, M., Gribbon, P., Kessler, T., Malik, R., Prestel, M., Stiller, B., Schofield, C., Pasterkamp, G., Watkins, H., Samani, N. J., Wittenberger, T., Erdmann, J., Schunkert, H., Asselbergs, F. W. & Björkegren, J. L. M., 01.12.2018, In: Scientific Reports. 8, 1, 3434.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

    Emdin, C. A., Khera, A. V., Klarin, D., Natarajan, P., Zekavat, S. M., Nomura, A., Haas, M., Aragam, K., Ardissino, D., Wilson, J. G., Schunkert, H., McPherson, R., Watkins, H., Elosua, R., Bown, M. J., Samani, N. J., Baber, U., Erdmann, J., Gormley, P., Palotie, A., & 6 othersStitziel, N. O., Gupta, N., Danesh, J., Saleheen, D., Gabriel, S. & Kathiresan, S., 16.01.2018, In: Circulation. 137, 3, p. 222-232 11 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • 2017

    A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

    Brænne, I., Willenborg, C., Tragante, V., Kessler, T., Zeng, L., Reiz, B., Kleinecke, M., Von Ameln, S., Willer, C. J., Laakso, M., Wild, P. S., Zeller, T., Wallentin, L., Franks, P. W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N. J., Asselbergs, F. W., Erdmann, J., & 1 othersSchunkert, H., 01.12.2017, In: Scientific Reports. 7, 1, 10252.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    1 Citation (Scopus)
  • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

    PROMIS and Myocardial Infarction Genetics Consortium Investigators, Stitziel, N. O., Khera, A. V., Wang, X., Bierhals, A. J., Vourakis, A. C., Sperry, A. E., Natarajan, P., Klarin, D., Emdin, C. A., Zekavat, S. M., Nomura, A., Erdmann, J., Schunkert, H., Samani, N. J., Kraus, W. E., Shah, S. H., Yu, B., Boerwinkle, E., Rader, D. J., & 9 othersGupta, N., Frossard, P. M., Rasheed, A., Danesh, J., Lander, E. S., Gabriel, S., Saleheen, D., Musunuru, K. & Kathiresan, S., 25.04.2017, In: Journal of the American College of Cardiology. 69, 16, p. 2054-2063 10 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    32 Citations (Scopus)
  • Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro

    Aherrahrou, R., Aherrahrou, Z., Schunkert, H. & Erdmann, J., 16.09.2017, In: Biochemical and Biophysical Research Communications. 491, 2, p. 396-402 7 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

    CARDIoGRAMplusC4D, Howson, J. M. M., Zhao, W., Barnes, D. R., Ho, W-K., Young, R., Paul, D. S., Waite, L. L., Freitag, D. F., Fauman, E. B., Salfati, E. L., Sun, B. B., Eicher, J. D., Johnson, A. D., Sheu, W. H. H., Nielsen, S. F., Lin, W-Y., Surendran, P., Malarstig, A., Wilk, J. B., & 31 othersTybjærg-Hansen, A., Rasmussen, K. L., Kamstrup, P. R., Deloukas, P., Erdmann, J., Kathiresan, S., Samani, N. J., Schunkert, H., Watkins, H., Do, R., Rader, D. J., Johnson, J. A., Hazen, S. L., Quyyumi, A. A., Spertus, J. A., Pepine, C. J., Franceschini, N., Justice, A., Reiner, A. P., Buyske, S., Hindorff, L. A., Carty, C. L., North, K. E., Kooperberg, C., Boerwinkle, E., Young, K., Graff, M., Peters, U., Absher, D., Hsiung, C. A. & Lee, W-J., 07.2017, In: Nature Genetics. 49, 7, p. 1113-1119 7 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus

    Kessler, T., Wobst, J., Wolf, B., Eckhold, J., Vilne, B., Hollstein, R., Von Ameln, S., Dang, T. A., Sager, H. B., Rumpf, P. M., Aherrahrou, R., Kastrati, A., Björkegren, J. L. M., Erdmann, J., Lusis, A. J., Civelek, M., Kaiser, F. J. & Schunkert, H., 01.08.2017, In: Circulation. 136, 5, p. 476-489 14 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

    CARDIoGRAM, The CARDIOGRAMplusC4D Consortium, MuTHER Consortium, Wellcome Trust Case Control Consortium, Brænne, I., Zeng, L., Willenborg, C., Tragante, V., Kessler, T., Willer, C. J., Laakso, M., Wallentin, L., Franks, P. W., Salomaa, V., Dehghan, A., Meitinger, T., Samani, N. J., Asselbergs, F. W., Erdmann, J., Schunkert, H., & 34 othersDeloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J. B., Johansson, Å., Hall, A., Lee, J. Y., Willer, C. J., Chambers, J. C., Esko, T., Folkersen, L., Goel, A., Grundberg, E., Havulinna, A. S., Ho, W. K., Hopewell, J. C., Burgdorf, C., Kessler, T., Maouche, S., Diemert, P., Schunkert, H., Erdmann, J., König, I. R., Schunkert, H. & Ziegler, A., 01.08.2017, In: PLoS ONE. 12, 8, e0182999.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

    Wild, P. S., Felix, J. F., Schillert, A., Teumer, A., Chen, M-H., Leening, M. J. G., Völker, U., Großmann, V., Brody, J. A., Irvin, M. R., Shah, S. J., Pramana, S., Lieb, W., Schmidt, R., Stanton, A. V., Malzahn, D., Smith, A. V., Sundström, J., Minelli, C., Ruggiero, D., & 104 othersLyytikäinen, L-P., Tiller, D., Smith, J. G., Monnereau, C., Di Tullio, M. R., Musani, S. K., Morrison, A. C., Pers, T. H., Morley, M., Kleber, M. E., Aragam, J., Benjamin, E. J., Bis, J. C., Bisping, E., Broeckel, U., Cheng, S., Deckers, J. W., Del Greco M, F., Edelmann, F., Fornage, M., Franke, L., Friedrich, N., Harris, T. B., Hofer, E., Hofman, A., Huang, J., Hughes, A. D., Kähönen, M., Investigators, K., Kruppa, J., Lackner, K. J., Lannfelt, L., Laskowski, R., Launer, L. J., Leosdottir, M., Lin, H., Lindgren, C. M., Loley, C., MacRae, C. A., Mascalzoni, D., Mayet, J., Medenwald, D., Morris, A. P., Müller, C., Müller-Nurasyid, M., Nappo, S., Nilsson, P. M., Nuding, S., Nutile, T., Peters, A., Pfeufer, A., Pietzner, D., Pramstaller, P. P., Raitakari, O. T., Rice, K. M., Rivadeneira, F., Rotter, J. I., Ruohonen, S. T., Sacco, R. L., Samdarshi, T. E., Schmidt, H., Sharp, A. S. P., Shields, D. C., Sorice, R., Sotoodehnia, N., Stricker, B. H., Surendran, P., Thom, S., Töglhofer, A. M., Uitterlinden, A. G., Wachter, R., Völzke, H., Ziegler, A., Münzel, T., März, W., Cappola, T. P., Hirschhorn, J. N., Mitchell, G. F., Smith, N. L., Fox, E. R., Dueker, N. D., Jaddoe, V. W. V., Melander, O., Russ, M., Lehtimäki, T., Ciullo, M., Hicks, A. A., Lind, L., Gudnason, V., Pieske, B., Barron, A. J., Zweiker, R., Schunkert, H., Ingelsson, E., Liu, K., Arnett, D. K., Psaty, B. M., Blankenberg, S., Larson, M. G., Felix, S. B., Franco, O. H., Zeller, T., Vasan, R. S. & Dörr, M., 2017, In: Journal of Clinical Investigation. 127, 5, p. 1798-1812 15 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

    Saleheen, D., Zhao, W., Young, R., Nelson, C. P., Ho, W., Ferguson, J. F., Rasheed, A., Ou, K., Nurnberg, S. T., Bauer, R. C., Goel, A., Do, R., Stewart, A. F. R., Hartiala, J., Zhang, W., Thorleifsson, G., Strawbridge, R. J., Sinisalo, J., Kanoni, S., Sedaghat, S., & 50 othersMarouli, E., Kristiansson, K., Zhao, J. H., Scott, R., Gauguier, D., Shah, S. H., Smith, A. V., Van Zuydam, N., Cox, A. J., Willenborg, C., Kessler, T., Zeng, L., Province, M. A., Ganna, A., Lind, L., Pedersen, N. L., White, C. C., Joensuu, A., Kleber, M. E., Hall, A. S., März, W., Salomaa, V., O'Donnell, C., Ingelsson, E., Feitosa, M. F., Erdmann, J., Bowden, D. W., Palmer, C. N. A., Gudnason, V., Faire, U. D., Zalloua, P., Wareham, N., Thompson, J. R., Kuulasmaa, K., Dedoussis, G., Perola, M., Dehghan, A., Chambers, J. C., Kooner, J., Allayee, H., Deloukas, P., McPherson, R., Stefansson, K., Schunkert, H., Kathiresan, S., Farrall, M., Marcel Frossard, P., Rader, D. J., Samani, N. J. & Reilly, M. P., 13.06.2017, In: Circulation. 135, 24, p. 2336-2353 18 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    3 Citations (Scopus)
  • Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease

    Wellcome Trust Case Control Consortium, Webb, T. R., Erdmann, J., Stirrups, K. E., Stitziel, N. O., Masca, N. G. D., Jansen, H., Kanoni, S., Nelson, C. P., Ferrario, P. G., König, I. R., Eicher, J. D., Johnson, A. D., Hamby, S. E., Betsholtz, C., Ruusalepp, A., Franzén, O., Schadt, E. E., Björkegren, J. L. M., Weeke, P. E., & 31 othersAuer, P. L., Schick, U. M., Lu, Y., Zhang, H., Dube, M-P., Goel, A., Farrall, M., Peloso, G. M., Won, H-H., Do, R., van Iperen, E., Kruppa, J., Mahajan, A., Scott, R. A., Willenborg, C., Braund, P. S., van Capelleveen, J. C., Doney, A. S. F., Donnelly, L. A., Asselta, R., Merlini, P. A., Duga, S., Marziliano, N., Denny, J. C., Shaffer, C., El-Mokhtari, N. E., Franke, A., Kessler, T., Vogt, T. F., Lieb, W. & Schunkert, H., 21.02.2017, In: Journal of the American College of Cardiology. 69, 7, p. 823-836 14 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • 2016

    A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

    Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., Grarup, N., Stancáková, A., Chen, Y., Varga, T. V., Yaghootkar, H., Luan, J., Zhao, J. H., Willems, S. M., Wessel, J., Wang, S., Maruthur, N., Michailidou, K., Pirie, A., van der Lee, S. J., & 30 othersGillson, C., Al Olama, A. A., Amouyel, P., Arriola, L., Arveiler, D., Aviles-Olmos, I., Balkau, B., Barricarte, A., Barroso, I., Garcia, S. B., Bis, J. C., Blankenberg, S., Boehnke, M., Boeing, H., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bowden, S., Caldas, C., Caslake, M., Cupples, L. A., Cruchaga, C., Czajkowski, J., den Hoed, M., Dunn, J. A., Earl, H. M., Ehret, G. B., Ferrannini, E., Erdmann, J. & Schunkert, H., 01.06.2016, In: Science Translational Medicine. 8, 341, p. 341ra76

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • A randomized, parallel group, double-blind study of ticagrelor compared with aspirin for prevention of vascular events in patients undergoing coronary artery bypass graft operation: Rationale and design of the Ticagrelor in CABG (TiCAB) trial: An Investigator-Initiated trial

    de Waha, A., Sandner, S., von Scheidt, M., Boening, A., Koch-Buettner, K., Hammel, D., Hambrecht, R., Danner, B. C., Schöndube, F. A., Goerlach, G., Fischlein, T., Schmoeckel, M., Oberhoffer, M., Schulz, R., Walther, T., Ziegelhöffer, T., Knosalla, C., Schönrath, F., Beyersdorf, F., Siepe, M., & 14 othersAttmann, T., Misfeld, M., Mohr, F. W., Sievers, H. H., Joost, A., Putman, L. M., Laufer, G., Hamm, C., Zeymer, U., Kastrati, A., Radke, P. W., Lange, R., Cremer, J. & Schunkert, H., 01.09.2016, In: American Heart Journal. 179, p. 69-76 8 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

    11 Citations (Scopus)
  • Classification of ADAMTS binding sites: The first step toward selective ADAMTS7 inhibitors

    Müller, M., Kessler, T., Schunkert, H., Erdmann, J. & Tennstedt, S., 11.03.2016, In: Biochemical and Biophysical Research Communications. 471, 3, p. 380-385 6 p.

    Research output: Journal ArticlesJournal articlesResearchpeer-review

  • Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease

    Stitziel, N. O., Stirrups, K. E., Masca, N. G. D., Erdmann, J., Ferrario, P. G., König, I. R., Weeke, P. E., Webb, T. R., Auer, P. L., Schick, U. M., Lu, Y., Zhang, H., Dube, M. P., Goel, A., Farrall, M., Peloso, G. M., Won, H. H., Do, R., Van Iperen, E., Kanoni, S., & 109 othersKruppa, J., Mahajan, A., Scott, R. A., Willenborg, C., Braund, P. S., Van Capelleveen, J. C., Doney, A. S. F., Donnelly, L. A., Asselta, R., Merlini, P. A., Duga, S., Marziliano, N., Denny, J. C., Shaffer, C. M., El-Mokhtari, N. E., Franke, A., Gottesman, O., Heilmann, S., Hengstenberg, C., Hoffmann, P., Holmen, O. L., Hveem, K., Jansson, J. H., Jöckel, K. H., Kessler, T., Kriebel, J., Laugwitz, K. L., Marouli, E., Martinelli, N., McCarthy, M. I., Van Zuydam, N. R., Meisinger, C., Esko, T., Mihailov, E., Escher, S. A., Alver, M., Moebus, S., Morris, A. D., Müller-Nurasyid, M., Nikpay, M., Olivieri, O., Perreault, L. P. L., AlQarawi, A., Robertson, N. R., Akinsanya, K. O., Reilly, D. F., Vogt, T. F., Yin, W., Asselbergs, F. W., Kooperberg, C., Jackson, R. D., Stahl, E., Strauch, K., Varga, T. V., Waldenberger, M., Zeng, L., Kraja, A. T., Liu, C., Ehret, G. B., Newton-Cheh, C., Chasman, D. I., Chowdhury, R., Ferrario, M., Ford, I., Jukema, J. W., Kee, F., Kuulasmaa, K., Nordestgaard, B. G., Perola, M., Saleheen, D., Sattar, N., Surendran, P., Tregouet, D., Young, R., Howson, J. M. M., Butterworth, A. S., Danesh, J., Ardissino, D., Bottinger, E. P., Erbel, R., Franks, P. W., Girelli, D., Hall, A. S., Hovingh, G. K., Kastrati, A., Lieb, W., Meitinger, T., Kraus, W. E., Shah, S. H., McPherson, R., Orho-Melander, M., Melander, O., Metspalu, A., Palmer, C. N. A., Peters, A., Rader, D. J., Reilly, M. P., Loos, R. J. F., Reiner, A. P., Roden, D. M., Tardif, J. C., Thompson, J. R., Wareham, N. J., Watkins, H., Willer, C. J., Kathiresan, S., Deloukas, P., Samani, N. J. & Schunkert, H., 24.03.2016, In: New England Journal of Medicine. 374, 12, p. 1134-1144 11 p.

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    97 Citations (Scopus)
  • Common and rare genetic variation in CCR2, CCR5, or CX3CR1 and risk of atherosclerotic coronary heart disease and glucometabolic traits

    Golbus, J. R., Stitziel, N. O., Zhao, W., Xue, C., Farrall, M., Mcpherson, R., Erdmann, J., Deloukas, P., Watkins, H., Schunkert, H., Samani, N. J., Saleheen, D., Kathiresan, S. & Reilly, M. P., 01.06.2016, In: Circulation: Cardiovascular Genetics. 9, 3, p. 250-258 9 p.

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    8 Citations (Scopus)
  • Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

    van der Laan, S. W., Fall, T., Soumaré, A., Teumer, A., Sedaghat, S., Baumert, J., Zabaneh, D., van Setten, J., Isgum, I., Galesloot, T. E., Arpegård, J., Amouyel, P., Trompet, S., Waldenberger, M., Dörr, M., Magnusson, P. K., Giedraitis, V., Larsson, A., Morris, A. P., Felix, J. F., & 52 othersMorrison, A. C., Franceschini, N., Bis, J. C., Kavousi, M., O'Donnell, C., Drenos, F., Tragante, V., Munroe, P. B., Malik, R., Dichgans, M., Worrall, B. B., Erdmann, J., Nelson, C. P., Samani, N. J., Schunkert, H., Marchini, J., Patel, R. S., Hingorani, A. D., Lind, L., Pedersen, N. L., de Graaf, J., Kiemeney, L. A. L. M., Baumeister, S. E., Franco, O. H., Hofman, A., Uitterlinden, A. G., Koenig, W., Meisinger, C., Peters, A., Thorand, B., Jukema, J. W., Eriksen, B. O., Toft, I., Wilsgaard, T., Onland-Moret, N. C., van der Schouw, Y. T., Debette, S., Kumari, M., Svensson, P., van der Harst, P., Kivimaki, M., Keating, B. J., Sattar, N., Dehghan, A., Reiner, A. P., Ingelsson, E., den Ruijter, H. M., de Bakker, P. I. W., Pasterkamp, G., Ärnlöv, J., Holmes, M. V. & Asselbergs, F. W., 30.08.2016, In: Journal of the American College of Cardiology. 68, 9, p. 934-945 12 p.

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    6 Citations (Scopus)